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Ophthalmic Disease in Twins: A Nationwide Record Linkage Study of Hospital Discharges and Free Medications for 16,067 Twin Pairs

Published online by Cambridge University Press:  01 August 2014

J.M. Teikari ,
J. Kaprio ,
M. Koskenvuo  and
A. Vannas
J.M. Teikari*
Affiliation:
Department of Public Health Science, University of Helsinki
J. Kaprio
Affiliation:
Department of Public Health Science, University of Helsinki
M. Koskenvuo
Affiliation:
Department of Public Health Science, University of Helsinki
A. Vannas
Affiliation:
Helsinki Military Hospital, Finland
*
Department of Public Health Science, Haartmaninkatu 3, 00290 Helsinki 29, Finland

Abstract

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Record linkage of the Finnish Twin Cohort Study with the Hospital Discharge Registry and with the Registry of Rights to Free Medication kept by the Social Insurance Institution gave following numbers of twin pairs with an ophthalmic disease (one or both members of the pair had the disease) in each disease category:98 with glaucoma simplex (5 concordant pairs), 38 with capsular glaucoma (no concordant pairs), 58 with iritis (no concordant pairs) and 149 with strabismus (2 concordant pairs).

The number of concordant pairs in each disease category was small, except for glaucoma simplex in which concordant pairs could be broken down by zygosity. The ratio of observed to expected (based on association by chance) was 6.96 for MZ and 1.74 for DZ pairs. This result suggests that genetic factors play some role in the variability of prevalence of simple glaucoma. Main etiologic factors are stili to be found in the environment. Data on occurrence of other diseases of ophtalmologic importance is presented.

Keywords

TwinHeritabilityGlaucomaStrabismusIritis
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 36 , Issue 4 , October 1987 , pp. 523 - 534
Copyright
Copyright © The International Society for Twin Studies 1987

References

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