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On the Statistical Significance of one Pair of Monozygotic Twins in Clinical Genetics1

Published online by Cambridge University Press:  01 August 2014

L. Gedda

Summary

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A case of one twin pair concordant or discordant as to a given disease is always very important for Clinical Genetics, especially when it is monozygotic. In Clinical Genetics, isolated pairs occur to the physician, and the diagnosis must therefore be based on intra-pair comparison. The statistical treatment of the case must consider the fact that a concordant monozygotic twin pair represents a statistical universe rather than a statistical unit. This entails taking into account many traits concerning the time of onset, the symptoms, development, result of treatment, etc. Suggestions are made for the statistical treatment of such cases.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 12 , Issue 4 , October 1963 , pp. 317 - 323
Copyright
Copyright © The International Society for Twin Studies 1963

Footnotes

1

Contribution n. 15-6 presented to the XI International Congress of Genetics, the Hague, 2-10 September 1963.

References

Literature

Gedda, L.: Twins in history and science. Ediz. Charles C. Thomas, Publisher, U.S.A., 1961.Google Scholar
Gedda, L., Brenci, G.: Lo studio dei gemelli in genetica umana, in « De Genetica Medica », Pars Secunda, Ediz. Ist. G. Mendel, Roma 1962.Google Scholar
Feller, W.: An introduction to probability theory and its application. New York, Wiley, 1960.Google Scholar
Ledley, and Lusted, : Reasoning foundations of medical diagnosis. Science, 130, 9–21, 1959.Google Scholar
Ledley, and Lusted, : Use of electronic computers to aid in medical diagnosis. Proc. Inst. of Radio Engineers, 47, 1970–1977, 1959.Google Scholar
Paycha, F.: Cybernétique de la consultation. Information et Cybernétique, Gauthier-Villars Editeurs, Paris 1963.Google Scholar