Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-22T14:14:43.654Z Has data issue: false hasContentIssue false
  • English
  • Français

Maternal Plasma Concentrations of Insulin-Like Growth Factor-I (IGF-I) and Human Placental Lactogen (hPL) in Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

R.R. Kazer ,
E.R. Cheng ,
T.G. Unterman  and
R.P. Glick
R.R. Kazer*
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
E.R. Cheng
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
T.G. Unterman
Affiliation:
Department of Medicine, Northwestern University Medical School, Chicago, Illinois
R.P. Glick
Affiliation:
Department of Neurosurgery, University of Illinois College of Medicine, and Veterans Administration West Side Medical Center, and Cook County Hospital, Chicago, Illinois
*
Center for Assisted Reproduction, Northwestern Medical Faculty Foundation, Inc., 680 North Lake Shore Drive, Suite 810, Chicago IL 60611, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Maternal plasma IGF-I and hPL concentrations were examined in 10 singleton pregnancies and in 11 twin gestations near term. hPL concentrations were higher in the twin pregnancies (14.4 ± 2.4 μg/1 vs 6.9 ± 0.9 μg/1, P < 0.02). In contrast, plasma IGF-I concentrations were similar in the singleton and twin pregnancies (533 ± 45 μg/1 vs 572 ± 60 μg/1, respectively). IGF-I concentrations failed to correlate with hPL concentrations in either group separately or when all subjects were considered together. These data do not support the hypothesis that maternal IGF-I secretion is an hPL-dependent process.

Keywords

TwinsInsulin-like growth factor-IHuman placental lactogen
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 383 - 387
Copyright
Copyright © The International Society for Twin Studies 1991

References

REFERENCES

1. Daughaday, WH, Trivedi, B, Winn, HN, Yan, H (1990): Hypersomatotropism in pregnant women as measured by a human liver radioreceptor assay. J Clin Endocrinol Metab 70:215–221.Google Scholar
2. Frankenne, F, Closset, J, Gomez, F, Scippo, ML, Smal, J, Hennen, G (1988): The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab 66:1171–1180.Google Scholar
3. Furlanetto, RW, Underwood, LE, Van Wyk, JJ, D'Ercole, AJ (1977): Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 60: 648–657.Google Scholar
4. Furlanetto, RW, Underwood, LE, Van Wyk, JJ, Handwerger, S (1978): Serum immunoreactive somatomedin-C is elevated late in pregnancy. J Clin Endocrinol Metab 47:695–698.CrossRefGoogle ScholarPubMed
5. Giudice, LC, Farrell, EM, Pham, H, Lamson, G, Rosenfeld, RG (1990): Insulin-like growth factor binding proteins (IGF-BPS) in serum during pregnancy and the puerperium: Depletion of IGF-BP-3 by endogenous pregnancy-associated protease actibity (Abstract). Program of the 72nd Annual Meeting of the Endocrine Society, Atlanta, Georgia, p 71.Google Scholar
6. Kaplan, SL, Grumbach, MM (1964): Studies of a human and simian placental hormone with growth hormone-like and prolactin-like activities. J Clin Endocrinol Metab 24:80–89.CrossRefGoogle ScholarPubMed
7. Kazer, RR, Unterman, TG, Glick, RP (1990): An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 71;958–962.Google Scholar
8. Spellacy, WN, Buhi, WC, Birk, SA (1978): Human placental lactogen levels in multiple pregnancies. Obstet Gynecol 52:210–215.Google Scholar