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La ricerca gemellologica nell'epilessia

Published online by Cambridge University Press:  01 August 2014

L. Braconi
L. Braconi*
Affiliation:
Istituto di Genetica Medica e Gemellologia «G. Mendel», (Roma)

Summary

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The A. has studied 51 pairs of epileptic twins: 20 were MZ (11 ♂, 9 ♀) and 31 DZ (9 ♂ 12 ♀, ♂♀).

An ereditary aetiology has been found in 65% of cases:

a) by the concordance of 80% of MZ against 35% of DZ. The MZ concordant in the symptomatic form were 62,5% the DZ 14, 5% the MZ concordant in the so-called idiopathic form were 91%, the DZ 50%.

b) by the incidence in one third of the families of a relative with epileptic seizures (3-4,7% against the 0,5% of general population).

Genic information is not specific either for the convulsive form nor for the electroencephalografic dysrythmia which are only some of the phenotypic manifestations of a deeper disturbance. The pathologic gene or genes should act at a metabolic level with a pleiotropic action upon more functions of the nervous system. The genetic action of the major gene is that of an autosomic, dominant one.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 11 , Issue 2 , April 1962 , pp. 138 - 157
Copyright
Copyright © The International Society for Twin Studies 1962

References

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