Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T13:52:25.081Z Has data issue: false hasContentIssue false
  • English
  • Français

La ricerca gemellologica nell'epilessia

Published online by Cambridge University Press:  01 August 2014

L. Braconi
L. Braconi*
Affiliation:
Istituto di Genetica Medica e Gemellologia «G. Mendel», (Roma)

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The A. has studied 51 pairs of epileptic twins: 20 were MZ (11 ♂, 9 ♀) and 31 DZ (9 ♂ 12 ♀, ♂♀).

An ereditary aetiology has been found in 65% of cases:

a) by the concordance of 80% of MZ against 35% of DZ. The MZ concordant in the symptomatic form were 62,5% the DZ 14, 5% the MZ concordant in the so-called idiopathic form were 91%, the DZ 50%.

b) by the incidence in one third of the families of a relative with epileptic seizures (3-4,7% against the 0,5% of general population).

Genic information is not specific either for the convulsive form nor for the electroencephalografic dysrythmia which are only some of the phenotypic manifestations of a deeper disturbance. The pathologic gene or genes should act at a metabolic level with a pleiotropic action upon more functions of the nervous system. The genetic action of the major gene is that of an autosomic, dominant one.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 11 , Issue 2 , April 1962 , pp. 138 - 157
Copyright
Copyright © The International Society for Twin Studies 1962

References

Bibliografia

Alström, C. H.: A study of Epilepsy in its clinicae, social and genetic aspects. Acta Psich.et Neur. Scand., Suppl. 63, 1950.Google Scholar
Amantea, M.: Epilessia sperimentale da eccitamenti afferenti. Policlinico sez. med., 1920.Google Scholar
Belloni, G. B.: Patologia e clinica delle Epilessie traumatiche. Rassegna di Neur. Vegetat. Vol. X, 513, 1954.Google Scholar
Bercel, N. A. e Beverly, H.: Diagnosis and treatment of epileptic and epileptoid disorders. J. A. M. A., 149, 1361, 1952.Google Scholar
Berg, J. M. e Kirman, B. H.: The mentally defective twin. Brit. Med. Journ., 1911, 06 1960.Google Scholar
Bini, L. e Bazzi, T.: Trattato di Psichiatria. Vol. II, 673, 1959.Google Scholar
Braconi, L. e Guerra, A.: Considerazioni su 180 casi di epilessia. Artis Med. Stu., vol. I, 130, 1960.Google Scholar
Buscaino, V. M. e Longo, V.: Ricerche speciali sulla tossicità del sangue degli epilettici. Riv. Pat. Nerv. e Ment., 48, 682, 1936.Google Scholar
Cohen of Birkenhead: Epilepsy as a social problem. Brit. Med. Jour., 672, 1958.Google Scholar
Conrad, C.: Die erbliche Fallsucht. Handbuch der Erbkrank. Leipzig, Thieme, 1940.Google Scholar
Cordier, J.: Quelques observations d'épilepsie « génétique ». Acta Neur. Belg., 58, 1–10, 1958.Google Scholar
Ey, H.: L'homme épileptique. Bull. Psych., 7, 26, 1953.Google Scholar
Fasanaro, M.: L'Epilessia riflessa e sperimentale. Acta Neurol., 2, 199, 1947.Google Scholar
Frisch, F. F.: Epilepsiepathogenese und der O. Foerstersche Hyperventilationsversuch. Z. Neur., 103, 243, 1926.Google Scholar
Gastaut, H.: The Epilepsies. Ed. Spriengfields, Thomas, 1954.Google Scholar
Gates, R. G.: Human genetics. The Mc Millan Co. N. Y., 1946.Google Scholar
Gedda, L.: Lo Studio dei Gemelli, Orizz. Med., 1951.Google Scholar
Gibbs, F. A. e Gibbs, E. L.: Electroencephalography. Addison-Wesley, 1952.Google Scholar
Gibbs, F. A. e Gibbs, E. L., Lennox, W. H.: Electroencephalographic classification of epileptic patients and control subjects. Arch. Neurol. & Psych., 50, 111, 1943.Google Scholar
Gozzano, M. e Vizioli, P.: Patogenesi dell'attacco epilettico. Atti del XII Congr. Soc. It. Neur., 1956.Google Scholar
Harvald, B.: Heredity in Epilepsy. Kobenhaven E. Munksgaard, 1954.Google Scholar
Harvald, B. Hereditary factors in Epilepsy. The Medical Clinics of North America, 03. 1958.Google Scholar
Hill, D.: Value of EEG in Diagnosis of Epilepsy. Brit. Med. Jour., 663, 1958.Google Scholar
Kallmann, F. J.: Heredity in health and in mental disorders. Ed. Norton, W. H. N. Y., 1953.Google Scholar
Kallmann, F. J. The genetics of epilepsy. Epilepsy. Grüne & Stratton N. Y., 1947.Google Scholar
Kanner, L.: Child Psychiatry. Thomas Springfield, 1947.Google Scholar
Kimball, O. P.: On the inheritance of Epilepsy. Jour. Wis. Sta. Med. Sec., 271, 05 1954.Google Scholar
Kimball, O. P. e Hersh, A. H.: The genetics of Epilepsy. A. Ge. Me. Ge., IV, 131, 1955.Google Scholar
Koch von, G.: Krampfbereitschaft. Ed. Mendel, G., 1955.Google Scholar
Kretschmer, E.: Psicologia Medica. Sansoni, ed., 1952.Google Scholar
Kretschmer, E. Körperbau und karakter. Springer Berlin, 1948.Google Scholar
Jasper, H. H. e Penfield, W.: EEgr. in post-traumatic epilepsy. Am. Jour. Psych., 100, 65, 1943.Google Scholar
Lennox, W. G.: The heredity of epilepsy as told by relatives and twins. J.A.M.A., 146, 229, 1951.Google ScholarPubMed
Lennox, W. G. Gibbs, E. L. e F. A., : Inheritance of cerebral dysrythmia and Epilepsy. Arch. Neur. & Psych., 44, 1155, 1940.CrossRefGoogle Scholar
Lennox, W. G. Gibbs, E. L. e F. A., The Brain-wave pattern, an hereditary trait. 36, 233, 1945.Google Scholar
Lennox, W. G., Collins, A. L.: Intelligence of normal and epileptic twins. Am. Jour. of Psych., 101, 764, 1945.Google Scholar
Lugaresi, E. e Sandri, M. R.: Gli aspetti psicopatologici dell'epilessia. Ed. Medica, Bologna, 1959.Google Scholar
Luxenburger, R. H.: Psychiatrische. u. Neurologische Zwillings pathologie. Zbl. ges. Neurol. Psych., 56, 145, 1930.Google Scholar
Mac Kay, R.: All epilepsy is one. AMA Arch. Neur., II/3, 237, 1960.CrossRefGoogle Scholar
Marchand, L. e Ajuriaguerra, J.: Epilepsies. Desclée de Brouwer. Paris, 1948.Google Scholar
Marchini, E. e Matarazzo, F.: Epilessia. Piccolo Male in due fratelli DZ. Riv. Neurol., XXIX, 243, 1959.Google Scholar
Merritt, H. H.: Medical Treatment in Epilepsy. Brit. Med. Jour., 666, 1958.CrossRefGoogle ScholarPubMed
Minkowska, F.: Le problème de la constitution. Évolution psychiat., To. II, 1927.Google Scholar
Moruzzi, G.: L'épilepsie expérimentale. Herman-Paris, 1950.Google Scholar
Ortiz, De Zarate I. C. e Rodriguez, J. A.: Herencia en la epilepsia. Rev. Neurol. Buenos Aires, 16/1, 1, 1958.Google Scholar
Pelliccioli-Garioni, : A. Ge. Me. Ge., IV, 342, 1955.Google Scholar
Penfield, W.: Classification of Epilepsies. Arch. Neur. and Psych., 60, 107, 1948.Google Scholar
Penfield, W., Kristiansen, K.: I tipi dell'accesso epilettico. Calia, Napoli, 1953.Google Scholar
Penfield, W., Jasper, H.: Epilepsy and the functional anatomy of the human brain. Ed. Churchill, J. & Churchill, A.. London, 1954.Google Scholar
Penfield, W., Pitfalls and success in surgical treatment of Epilepsy. Brit. Med. Jour., 669, 1958.Google Scholar
Pescetto, G. e Paladini, G. P.: Contributo allo studio dell'epilessia nei gemelli. Sistema Nervoso, 10/3, 216, 1958.Google Scholar
Pond, D. A.: Aspetti psichiatrici dell'epilessia. Rec. Pogr. Med., 1914/325, 1955.Google Scholar
Reed, S.: Consulenza in Genetica Medica. Ed. Mendel, G., 1959.Google Scholar
Roberts, Fraser J. A.: An Introduction to Medical Genetics. Oxford Un. Press, 1959.Google Scholar
Rosanoff, J.-Handy, L. M. e Rosanoff, I. A.: Etiology of Epilepsy. Arch. Neur. & Psych., 31, 1165, 1931.Google Scholar
Sal y, Rosas F.: Le caractère épileptique. Rev. Psych. Appl., 3, 260, 1953.Google Scholar
Sanders, J. (citato da Gates): Zwillinge mit Epilepsie. Genetica, 15/67, 1953.Google Scholar
Schergna, E.: Epilessie da traumi cranio-encefalici chiusi. Rassegna di Neurol, e Veget., Vol. X, 566 e ss., 1954.Google Scholar
Schulz, H. E.: Zür Frage des epilektischen anfalls in insulinoschock. Psych. Neur. Wocherschr., 28, 307, 1938.Google Scholar
Serra, C. e Pannain, B.: L'ereditarietà dell'attività elettrica corticale ecc. Annali di Neurop. e Psicanal., vol. 4, 419, 1960.Google Scholar
Slater, E.: Psychotic and neurotic illnesses in twins. London, 1953.Google Scholar
Vercelletto, O.: La prédisposition à l'épilepsie. Expansion Scientifique Franç., Paris, 1954.Google Scholar
Vislie, H. e Henriksen, G. F.: Psychic disturbances in epileptics. In Lectures on Epilepsy. Lorenz de Haas, 1958.Google Scholar
Vogel, A.: citato da Serra e Pannain.Google Scholar
Weiss, Valbranca G. e Bencini, A.: I problemi dell'epilessia nelle sue recenti acquisizioni ecc. Rassegna Neur. Veget., Vol. V. X. 692 e ss., 1954.Google Scholar
Williams, D.: Modern views on the classification of Epilepsy. Brit. Med. Jour., 661, 1958.Google Scholar
Zazzo, R.: Les jumeaux. Vol. I e II. Presse Univ. Fr., 1960.Google Scholar