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La Genetica del Diabete1

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
D. Casa  and
G. Brenci
L. Gedda*
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
D. Casa
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Roma
*
Istituto di Genetica Medica e Gemellologia Gregorio Mendel, Piazza Galeno 5, 00161 Roma, Italy

Summary

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The introduction of informatics in the study of hereditary diseases, i.e., the birth of informatic medical genetics, marks a turning point in the history of medicine.

The biological informatics is the product of molecular genetics on one hand, and cybernetics on the other. The former has brought the study of the hereditary phenomena to the level of nucleic acids; while the latter, originally devised to the service of automation, reflects a number of fundamental biological phenomena, also at the molecular level.

The informatics of hereditary diseases is referred to a damage of the operative units acting to secure the development and homeostasis of the organism. The mechanistic conception of the damage is complemented by the energetic and chronologic concept.

On such foundations a modern conception of the genetics of diabetes is thus formulated. The clinical inadequacy of the static genealogical model is stressed, and the introduction of a dynamic model is suggested, taking into account the gradual chronological extinction of the normoglycemic genotype.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 20 , Issue 3 , July 1971 , pp. 227 - 236
Copyright
Copyright © The International Society for Twin Studies 1971

Footnotes

1

Conferenza tenuta in occasione della Settimana degli Ospedali, Roma.

References

Bibliografia

Annuario di statistighe sanitarie (1957–1966). Vols. III-XII, Roma.Google Scholar
Barrai, I., Cann, H. M. (1965). Segregation analysis of juvenile diabetes mellitus. J. Med. Genet., 2: 8.Google Scholar
Kent, G. T., Leonards, J. R. (1968). Analysis of tests for diabetes in 250,000 persons screened for diabetes, using finger blood after a carbohydrate load. Diabetes, 17: 274.Google Scholar
Marigo, S. (1970). Attuali vedute sulla patogenesi del diabete mellito. Acta Diabetol. Lat., 3: 457–470.Google Scholar
McKusick, V. A. (1966). Mendelian Inheritance in Man. Catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes. The Johns Hopkins Press, Baltimore.Google Scholar
Nilsson, S. E. (1964). On the heredity of diabetes mellitus and its interrelationship with some other diseases. Acta Genet. (Basel), 14: 97–124.Google Scholar
Simpson, N. E. (1962). The genetics of diabetes: a study of 233 families of juvenile diabetics. Ann. Hum. Genet., 26: 1.Google Scholar
US National Center for Health Statistics (1964). Glucose Tolerance of Adults. 11: 2.Google Scholar