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Intrapair Differences of the Blood Cell Components and Lymphocyte Subsets in Monozygotic and Dizygotic Twins

Published online by Cambridge University Press:  01 August 2014

Y. Yokoyama  and
T. Akiyama
Y. Yokoyama*
Affiliation:
Department of Public Health, Kinki University School of Medicine, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan
T. Akiyama
Affiliation:
Central Clinical Laboratory, Kinki University Hospital, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan
*
Department of Public Health, Kinki University School of Medicine, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan

Abstract

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We evaluated the relative influence of genetic and environmental factors on leukocytes, lymphocytes, neutrophils, monocytes, erythrocytes, reticulocytes, hemoglobin, platelets, T lymphocyte subsets, and NK marker cells in monozygotic (MZ) and dizygotic (DZ) twins. Peripheral blood components were measured in 154 healthy twin pairs (118 MZ pairs and 36 DZ pairs) and lymphocyte subsets in 48 healthy twin pairs (38 MZ pairs and 10 DZ pairs).

Platelets and erythrocytes showed higher intraclass correlations in the MZ pairs than in the DZ pairs in the males. However, in the females, the intraclass correlations for these components were similar between the MZ and DZ pairs. Neutrophils and monocytes showed low intraclass correlations in the MZ pairs. The absolute number of CD4+ cells and the CD4+/CD8+ cell ratio showed high intraclass correlations regardless of age in the MZ pairs in both males and females. The intraclass correlation for the absolute number of CD3+ cells was low in pairs aged ≥ 60 years in the MZ pairs. The absolute numbers of CD16+ cells and CD56+ cells showed high intraclass correlations regardless of age in the MZ pairs.

Keywords

TwinsPlateletErythrocyteT lymphocyte subsetNK cellAge
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 44 , Issue 3-4 , October 1995 , pp. 203 - 214
Copyright
Copyright © The International Society for Twin Studies 1995

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