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Inheritance and Alcohol as Factors Influencing Plasma Uric Acid Levels

Published online by Cambridge University Press:  01 August 2014

J.B. Whitfield  and
N.G. Martin
J.B. Whitfield*
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
N.G. Martin
Affiliation:
Department of Population Biology, Research School of Biological Sciences, Australian National University, Canberra
*
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Abstract

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Variation in plasma uric acid levels in 206 pairs of male and female twins, aged from 18 to 34 years, was consistent with a simple model including only individual environmental and additive genetic effects and a heritability of h2 = 0.73. Individual environmental variation was estimated to be approximately the same as variation of individuals measured on two occasions. Correlations of DZ pairs were also consistent with sex-linked genetic effects. In men there was a significant genetic correlation with weekly alcohol consumption and as much as 18% of the variation in uric acid levels could be accounted for by genetic variation in alcohol consumption.

Keywords

TwinsUric acidAlcohol
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 2 , April 1983 , pp. 117 - 126
Copyright
Copyright © The International Society for Twin Studies 1983

References

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