Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-23T05:57:30.420Z Has data issue: false hasContentIssue false
  • English
  • Français

Inheritance and Alcohol as Factors Influencing Plasma Uric Acid Levels

Published online by Cambridge University Press:  01 August 2014

J.B. Whitfield  and
N.G. Martin
J.B. Whitfield*
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
N.G. Martin
Affiliation:
Department of Population Biology, Research School of Biological Sciences, Australian National University, Canberra
*
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Variation in plasma uric acid levels in 206 pairs of male and female twins, aged from 18 to 34 years, was consistent with a simple model including only individual environmental and additive genetic effects and a heritability of h2 = 0.73. Individual environmental variation was estimated to be approximately the same as variation of individuals measured on two occasions. Correlations of DZ pairs were also consistent with sex-linked genetic effects. In men there was a significant genetic correlation with weekly alcohol consumption and as much as 18% of the variation in uric acid levels could be accounted for by genetic variation in alcohol consumption.

Keywords

TwinsUric acidAlcohol
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 2 , April 1983 , pp. 117 - 126
Copyright
Copyright © The International Society for Twin Studies 1983

References

REFERENCES

1.Boyle, JA, Grieg, WR, Jasani, MK, Duncan, A, Diver, M, Buchman, WW (1967): Relative role of genetic and environmental factors in the control of serum uric acid levels in normouricaemic subjects. Ann Rheum Dis 26:234–237.CrossRefGoogle Scholar
2.Clark, P, Jardine, R, Martin, NG, Stark, AE, Walsh, RJ (1980): Sex differences in the inheritance of some anthropometric characters in twins. Acta Genet Med Gemellol 29:171–192.Google Scholar
3.Eaves, LJ, Last, KA, Young, PA, Martin, NG (1978): Model-fitting approaches to the analysis of human behaviour. Heredity 41:249–320.Google Scholar
4.Havlik, R, Garrison, R, Fabsitz, R, Feinleib, M (1977): Genetic variability of clinical chemical values. Clin Chem 23:659–662.Google Scholar
5.Jensen, J, Blankenborn, DH, Chin, HP, Sturgeon, P, Ware, AG (1965): Serum lipids and serum uric acid in human twins. J Lipid Res 6:193–205.Google Scholar
6.Lieber, CS, Jones, DP, Losowsky, MS, Davidson, CS (1960): Interrelation of uric acid and ethanol metabolism in man. J Clin Invest 42:1863–1870.Google Scholar
7.Martin, NG, Oakeshott, JG, Gibson, JB, Wilks, AV, Starmer, GA, Whitfield, JB (1981): Prodromus to a twin study of sensitivity to intoxication and alcohol metabolism. Aust NZ J Med 11:140–143.Google Scholar
8.Mather, K, Jinks, JL (1974): “Biometrical Genetics,” 2nd Ed. London: Chapman and Hall, pp 292–293.Google Scholar
9.Mikkelsen, WM, Dodge, HJ, Valkeburg, H (1965): The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia. Am J Med 39:242–251.Google Scholar
10.Park, K-S, Inouye, E, Asaka, A (1980): Plasma and urine uric acid levels: Heritability estimates and correlation with IQ. Jpn J Human Genet 25:193–202.Google Scholar
11.Partanen, J, Bruun, K, Markkanen, T (1966): Inheritance of drinking behaviour. Helsinki: Finnish Foundation for Alcohol Studies.Google Scholar
12.Rao, DC, Laskarzewski, PM, Morrison, JA, Khoury, P, Kelly, K, Glueck, CJ (1982): The Cincinnati lipid research clinic family study: Familial determinants of plasma uric acid. Hum Genet 60:257–261.Google Scholar
13.Rich, RL, Nance, WE, Corey, LA, Boughman, JA (1978): Evidence for genetic factors influencing serum uric acid levels in man. In Nance, WE (ed): “Twin Research Part C: Progress in Clinical and Biological Research.” New York: Alan R Liss, Inc., pp 187–192.Google Scholar
14.Sobrinho-Simoes, M (1965): A sensitive method for the measurement of serum uric acid using hydroxylamine. J Lab Clin Med 65:665–668.Google ScholarPubMed
15.Van Steirteghem, AC, Robertson, EA, Young, DS (1978): Variance components of serum constituents in healthy individuals. Clin Chem 24:212–222.CrossRefGoogle ScholarPubMed
16.Whitfield, JB, Hensley, WJ, Bryden, D, Gallagher, H (1978): Some laboratory correlates of drinking habits. Ann Clin Biochem 15:297–303.CrossRefGoogle ScholarPubMed
17.Williams, GZ, Widdowson, GM, Penton, J (1978): Individual character of variation in time-series studies of healthy people. Clin Chem 24:313–320.Google Scholar
18.Wolfson, WQ, Hunt, HD, Levine, R, Guterman, HS, Cohn, C, Rosenberg, EF, Huddlestun, B, Kadota, K (1949): The transport and excretion of uric acid in man. A sex difference in urate metabolism. J Clin Endocrinol 9:749–767.Google Scholar
19.Wyngaarden, JB, Kelley, WN (1978): Gout. In Stanbury, JB, Wyngaarden, JB, Fredrickson, DS (eds): “The Metabolic Basis of Inherited Disease,” 4th Ed. New York: McGraw-Hill.Google Scholar