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Infantile hypertrophic pyloric stenosis: data on 81 pairs of twins

Published online by Cambridge University Press:  01 August 2014

Brian MacMahon  and
Thomas McKeown
Brian MacMahon
Affiliation:
From the Department of Social Medicine, University of Birmingham
Thomas McKeown
Affiliation:
From the Department of Social Medicine, University of Birmingham

Summary

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87 affected twins (in 81 pairs) were identified among 3,982 children with pyloric stenosis. The proportion of twins among affected (1 in 46) is about the same as in the general population of births. The incidence of pyloric stenosis in partners of affected twins is 8.6 per cent, considerably higher than in the general population of births (0.3 per cent) but only slightly higher than in subsequent sibs (5.8 per cent).

The frequency of concordance is about the same in MM (4 of 31) and MF (2 of 23) pairs. Of 39 like sexed pairs 4 were concordant; the expected number of monozygotic pairs is 18 (assuming the usual proportion of monozygotic pairs), which suggests that the frequency of concordance among them is not greater than 4 in 18. It is shown that the distribution of MM, FF and MF pairs in the series corresponds closely to the distribution expected in a twin universe which contains the usual proportions of monozygotic and dizygotic twin pairs.

Riassunto

RIASSUNTO

87 gemelli colpiti (su 81 coppie) sono stati identificati fra 3.982 bambini affetti da stenosi pilorica. La proporzione dei gemelli fra i colpiti (1 su 46) è circa la stessa che nella popolazione generale delle nascite. L'incidenza della stenosi pilorica nei cogemelli di individui affetti è 8,6 per cento, considerevolmente più alta che nella popolazione generale delle nascite (0,3 per cento), ma solo leggermente più alta che nei fratelli successivi (5,8 per cento).

La frequenza della concordanza è circa la stessa nelle coppie MM (4 su 31) ed MF (2 su 23). Di 39 coppie dello stesso sesso 4 erano concordanti; il numero previsto di coppie monozigotiche è 18 (supponendo la proporzione usuale di coppie monozigotiche), il che suggerisce che la frequenza della concordanza fra di essi non sia superiore a 4 su 18. Viene dimostrato che la distribuzione di coppie MM, FF ed MF nella serie, corrisponde da vicino alla distribuzione prevista in una popolazione gemellare che contenga la consueta proporzione di coppia gemellari monozigotiche e dizigotiche.

Résumé

RÉSUMÉ

87 jumeaux atteints (sur 81 couples) on été identifiés sur 3.982 enfants malades de sténose pilorique. La proportion des jumeaux parmi les malades (1 sur 46) est environ la même que dans la population générale des naissances. L'incidence de la sténose pilorique dans les co-jumeaux d'individus affectés est de 8,6 pour cent, considérablement plus élevée que dans la population générale des naissances (0,3 pour cent), mais seulement légèrement plus élevée que dans les frères successifs (5,8 pour cent).

La fréquence de la concordance est environ la même dans les couples MM (4 sur 31) et MF (2 sur 23). Sur 39 couples du même sexe, 4 étaient concordants; le nombre prévu de couples MZ est 18 (en supposant la proportion habituelle de couples MZ), ce qui suggère que la fréquence de la concordance entre eux n'est pas supérieure à 4 sur 18. Il est en effet démontré que la distribution de couples MM, FF et MF dans la série, correspond de près à la distribution prévue dans une population gémellaire qui renferme la proportion habituelle de couples gémellaires MZ et DZ.

Zusammenfassung

ZUSAMMENFASSUNG

Von 3,982 mit Pylorusstenose behafteten Kindern waren 87 Zwillinge (von 81 Zwillingspaaren). Die Proportion von Zwillingen bei den Kindern mit Pylorusstenose ist 1 in 46, was ungefähr der Proportion von Zwillingsgeburten bei den Gesammtgeburten entspricht. Das Vorkommen von Pylorusstenose in Partnern von Zwillingen mit Pylorusstenose ist 8.6%, also bedeutend grösser als das Vorkommen von Pylorusstenose bei den Gesammtgeburten (0.3%), aber nur ein wenig grösser als dasselbe bei später geborenen Geschwistern (5.8%).

Die Häufigkeit der konkordanten Zwillingspaare ist ungefähr dieselbe in MM (4 von 31) und MF (2 von 23) Paaren. Von 39 Paaren des gleichen Geschlechtes waren 4 Paare konkordante; die zu erwartende Zahl von eineiigen Paaren ist 18 (die gewöhnliche Proportion von eineiigen Paaren angenommen), was bedeuted, dass die Häufigkeit von konkordanten Zwillingspaaren innerhalb eineiiger Paare nicht grösser als 4 in 18 ist. Es wird gezeigt, dass die Verteilung von MM, FF und MF Paaren in den Daten dieses Werkes ähnlich ist der Verteilung, die man in einer Gruppe von Zwillingen, welche die gewöhnliche Proportion von eineiigen und zweieinigen Zwillingspaaren enthält, erwartet.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 4 , Issue 3 , September 1955 , pp. 320 - 329
Copyright
Copyright © The International Society for Twin Studies 1955

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