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High Rate of Twins among Offspring of Mothers with the Järvi-Hakola-Nasu Disease and with Comments on Disorders Associated with Twinning

Published online by Cambridge University Press:  01 August 2014

H. P. A. Hakola  and
A. W. Eriksson
H. P. A. Hakola*
Affiliation:
The Department of Forensic Psychiatry, University of Kuopio, Finland
A. W. Eriksson
Affiliation:
Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland
*
Niuvanniemi Hospital, University of Kuopio, Department of Forensic Psychiatry, FIN-70240 Kuopio, Finland

Abstract

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Finnish mothers with Järvi-Hakola-Nasu disease, progressive dementia with lipomembranous polycystic osteodysplasia (McKusick 221770) have a high rate of twin maternities, 128.2/1000. The exact 99% confidence intervals are 28.7 – 322.2/1000, thus above the average twinning rate in Finland, i.e. 15/1000. This eightfold increase in twinning may be an indication of a disturbed cortico-hypothalmic-hypophyseal axis or an other premorbid hormonal imbalance. It is concluded that even if dizygotic twinning is as a rule an event in itself, not only iatrogenic factors, as ovulation inducers, etc., but also some genetic disorders may be associated with twinning. More studies are needed to elucidate the incidence of twinning in families with these disorders.

Keywords

Twinning rateFinlandNasu-Hakola diseaseBrain-bone-fat diseasePolycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathyPre-senile progressive dementiaAssociations with twinning
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 46 , Issue 1 , January 1997 , pp. 37 - 46
Copyright
Copyright © The International Society for Twin Studies 1997

References

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