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Haemoglobinopathies in the Indian Subcontinent. A Review of Literature

Published online by Cambridge University Press:  01 August 2014

N. Saha  and
B. Banerjee
N. Saha*
Affiliation:
Department of Human Biology, The John Curtin School of Medical Research, Canberra, Australia
B. Banerjee
Affiliation:
Department of Physiology, Haile Sellassie I University, Addis Ababa, Ethiopia
*
Department of Human Biology, J.C.S.M.R., Box 334, Canberra City — A.C.T. 2601, Australia

Summary

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An up-to-date review of literature on the distribution of haemoglobinopathies in the Indian subcontinent has been presented. Haemoglobins S, D, E, J, K, L, M, Q, β-thalassaemia major, β-thalassaemia minor, α-thalassaemia minor, haemoglobin H, haemoglobin Lepore and persistence of foetal haemoglobin have been reported from India, β-thalassaemia in combination with haemoglobins S, E, D, J, K, Q has also been reported. Haemoglobin S is found to be prevalent among tribal populations in various regions of India, while haemoglobin D is prevalent among Sikhs, Pathans and Gujratis. Haemoglobin E is present in high frequency among populations of Assam, Bengal and Veddahs of Ceylon. β-thalassaemia major is widespread in various populations. There is paucity of data regarding distribution of β-thalassaemia minor and α-thalassaemias in this region.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 22 , Issue 1 , January 1973 , pp. 117 - 138
Copyright
Copyright © The International Society for Twin Studies 1973

References

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