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Guidelines for the Prevention of Multiple Pregnancy in Treatment by in Vitro Fertilization

Published online by Cambridge University Press:  01 August 2014

F. Leroy ,
F. Puissant ,
P. Barlow  and
G. de Maertelaer
F. Leroy*
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
F. Puissant
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
P. Barlow
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
G. de Maertelaer
Affiliation:
IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Belgium
*
Department of Obstetrics and Gynecology, Saint Pierre Hospital, Rue Haute 322, B-1000 Brussels, Belgium

Abstract

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Within the same in vitro fertilization (IVF) program, treatment trials leading to single and multiple ongoing gestation were compared. Rates of cesarean delivery, prematurity and perinatal mortality were found much higher among twin and multiple IVF pregnancies. Our work thus attempts at defining characteristics of proneness to multiple gestation in IVF treatment, in order to try and avoid its occurrence. The mean vitality score of embryos replaced is the most reliable criterion for this purpose, enabling one to replace no more than two embryos when the average score is high. Age of the patient and cause of infertility are almost nondiscriminant in this respect. Ovarian stimulation parameters such as total dosage of gonadotropin treatment and level of estrogenic response, as well as numbers of oocytes and embryos obtained, may serve as secondary criteria for assessing the twinning risk.

Keywords

In vitro fertilizationOvarian stimulationEmbryosTwinning risk
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 3 , July 1990 , pp. 371 - 378
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

1.Borlum, K (1989): Triplets in Denmark, 1980-1989 (abstact). Acta Genet Med Gemellol 38:166.Google Scholar
2.Bulmer, MG (1979): The Biology of Twinning in Man. Oxford: Clarendon Press, pp 74–82.Google Scholar
3.Cluydts, N (1988): Forty Years of Twinning in St. Pierre Hospital (in Dutch). Brussels: Flemish Free University, p 58.Google Scholar
4.Derom, R, Vlietinck, R, Derom, C, Thiery, M (1989): Comparative study of outcome and zygosity in spontaneous and induced multiple pregnancies (abstract). Acta Genet Med Gemellol 38:158.Google Scholar
5.Edwards, RG (1983): The current clinical success of human in vitro fertilization: In Feichtinger, W, Kemeter, P (eds): Recent Progress in Human in Vitro Fertilization: Palermo, COFESE, pp 9–22.Google Scholar
6.Elkhazen, N, Puissant, F, Camus, M, Lejeune, B, Leroy, F (1986): A comparison between multiple and single pregnancies obtained by in vitro fertilization. Hum Reprod 1:251–254.Google Scholar
7.Lejeune, B, Degueldre, M, Camus, M, Vekemans, M, Opsomer, L, Leroy, F (1986): In vitro fertilization and embryo transfer as related to endogenous luteinizing hormone rise or human chorionic gonadotropin administration. Fertil Steril 45:377–383.CrossRefGoogle ScholarPubMed
8.Leroy, F (1976): Major fetal hazards in multiple pregnancy. Acta Genet Med Gemellol 25:299–306.CrossRefGoogle ScholarPubMed
9.MacFarlane, A, Daw, EG (1989): Assisted reproduction and triplet and higher order births (abstract). Acta Genet Med Gemellol 38:159.Google Scholar
10.Pons, JC, Segard, L, Rais, S, Papiernik, E (1989): Management of triplet pregnancy (abstract). Acta Genet Med Gemellol 38:167.Google Scholar
11.Puissant, F, Van Rysselberge, M, Barlow, P, Deweze, J, Leroy, F (1987): Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod 2:705–708.Google Scholar
12.Société Royale Belge de Gynécologie et d'Obstétrique (1987): Atlas de la Santé Périnatale et Infantile en Belgique, p 42.Google Scholar
13.Steptoe, PC (1985): Abnormal implantation, abortion and births after in vitro fertilization. In Edwards, RG, Purdy, JM, Steptoe, PC (eds): Implantation of the Human Embryo. London: Academic Press, pp 435–444.Google Scholar
14.Tresmontant, R, Papiernik, E (1983): Economic analysis of the prevention of preterm births in twin pregnancies. Europ J Obstet Gynecol Reprod Biol 15:277–279.Google Scholar
15.Van Rysselberge, M, Puissant, F, Barlow, P, Lejeune, B, Delvigne, A, Leroy, F (1989): Fertility prognosis in IVF treatment of patients with cancelled cycles. Hum Reprod 4:663–666.CrossRefGoogle ScholarPubMed
16.Voluntary Licensing Authority for Human in Vitro Fertilization and Embryology (UK) (1989): Fourth Annual Report, p 21.Google Scholar
17.Walters, DE, Edwards, RG, Meistrich, ML (1985): A statistical evaluation of implantation after replacing one or more human embryos. J Reprod Fertil 74:557–563.CrossRefGoogle ScholarPubMed