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Genetics of Plasma Cholesterol and Triglycerides: A Study of Adult Male Twins*

Published online by Cambridge University Press:  27 January 2025

Joe C. Christian ,
Manning Feinleib ,
Stephen B. Hulley ,
William P. Castelli ,
Richard R. Fabsitz ,
Robert J. Garrison ,
Nemat O. Borhani ,
Ray H. Rosenman  and
John Wagner
Joe C. Christian*
Affiliation:
Indiana University Medical School, Indianapolis, Indiana, USA
Manning Feinleib
Affiliation:
National Institues of Health, National Heart & Lung Institute Division of Heart & Vascular Diseases, Bethesda, Maryland, USA
Stephen B. Hulley
Affiliation:
Pacific Medical Center, San Francisco, California, USA
William P. Castelli
Affiliation:
National Institues of Health, National Heart & Lung Institute Division of Heart & Vascular Diseases, Bethesda, Maryland, USA
Richard R. Fabsitz
Affiliation:
National Institues of Health, National Heart & Lung Institute Division of Heart & Vascular Diseases, Bethesda, Maryland, USA
Robert J. Garrison
Affiliation:
National Institues of Health, National Heart & Lung Institute Division of Heart & Vascular Diseases, Bethesda, Maryland, USA
Nemat O. Borhani
Affiliation:
University of California, School of Medicine, Davis, California, USA
Ray H. Rosenman
Affiliation:
Mount Zion Hospital & Medical Center, San Francisco, California, USA
John Wagner
Affiliation:
Rancho Los Amigos Hospital, Downey, California, USA
*
Department of Medical Genetics, School of Medicine, University of Indiana, Indianapolis, Indiana, USA

Abstract

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Fasting plasma triglycerides and cholesterol, as well as cholesterol in very low density, low density and high density lipoproteins, were measured in 250 MZ and 264 DZ adult male twin pairs. A new method was used to choose an estimate of genetic variance. This includes an estimate of genetic variance for use when the total variances of MZ and DZ twins are unequal. DZ twins had greater total variance for cholesterol. When genetic variance was estimated by subtracting the within-MZ-sets mean square from the within-DZ-sets mean square, all of the lipids had significant estimates of genetic variance; however, when genetic variance was estimated by a method designed to correct bias due to unequal total variances of MZ and DZ twins, only triglycerides had significant genetic variance. The heritability of plasma triglycerides was calculated to be 0.68.

Type
5. Twin Studies in Human Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , January 1976 , pp. 145 - 149
Copyright
Copyright © The International Society for Twin Studies 1976

Footnotes

*

Supported by research contracts (NIH-70-2246; NIH-70-2268; NIH-71-2307) with the National Heart and Lung Institute.

References

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