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Genetic Variation and Plasma Creatine Kinase Activity

Published online by Cambridge University Press:  01 August 2014

J.B. Whitfield  and
N.G. Martin
J.B. Whitfield*
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
N.G. Martin
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond
*
Dept. of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Abstract

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The distribution of plasma creatine kinase (CK; E.C.2.7.3.2) is known to be skewed, and this has made it difficult to analyse the sources of variation. We have studied plasma CK in 206 pairs of twins and have analysed the results after separating them into what appear to be two Gaussian frequency distributions. The results in the main distribution (CK < 300 iu/1) are apparently affected by genetic factors common to both men and women, and by environmental factors which are of much greater effect in men. The tendency for some men to have very high CK values may also have a genetic basis.

Keywords

Creatine kinaseGenetic factorsRepeatabilityTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 35 , Issue 1-2 , April 1986 , pp. 23 - 33
Copyright
Copyright © The International Society for Twin Studies 1986

References

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