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Genetic Models of Affective Disorder: Application to Twin Data

Published online by Cambridge University Press:  01 August 2014

Miron Baron
Miron Baron*
Affiliation:
Department of Medical Genetics, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York
*
New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032

Abstract

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Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.

Keywords

Affective disorderGenetic modelsTwin concordance
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 4 , October 1980 , pp. 289 - 294
Copyright
Copyright © The International Society for Twin Studies 1980

References

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