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Genetic Aspects of Childhood Tumours

Published online by Cambridge University Press:  01 August 2014

J. François ,
S. De Bie  and
M. Matton
J. François*
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
S. De Bie
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
M. Matton
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
*
Ophthalmological Clinic, University Hospital, De Pintelaan 135, B 9000 Ghent, Belgium

Abstract

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Present concepts on the etiology of childhood tumours are reviewed. The differences in clinical manifestations of the hereditary and nonhereditary types are illustrated with data on retinoblastoma and on nephroblastoma. Notwithstanding these differences it is most likely that the fundamental etiologic process is the same in both and that it consists in successive mutational events. The possible consequences of the association of retinoblastoma with a deletion of chromosome 13 in some cases are discussed. Several explanations for the association of Wilms' tumour and aniridia are also discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 145 - 149
Copyright
Copyright © The International Society for Twin Studies 1975

References

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