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Genetic and Environmental Determinants of 17 Serum Biochemical Traits in Brazilian Twins

Published online by Cambridge University Press:  01 August 2014

Gloria M.D. Dal Colletto ,
Henrique Krieger  and
José Reinaldo Magalhães
Gloria M.D. Dal Colletto*
Affiliation:
Departamento de Biologia, Instituto de Biociências, USP, São Paulo, Brazil
Henrique Krieger
Affiliation:
Centro de Referência Genética, UFSCar, São Carlos, Brazil
José Reinaldo Magalhães
Affiliation:
Departamento de Biofisica, Escola Paulista de Medicina, São Paulo, Brazil
*
Departamento de Biologia, Universidade de São Paulo, Caixa Postal 11461, 05421 São Paulo, SP, Brazil

Abstract

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The genetic and environmental effects on the levels of 17 serum biochemical quantitative traits (calcium, phosphorus, glucose, urea nitrogen, uric acid, total protein, albumin, total bilirubin, alkaline phosphatase, lactate dehydrogenase (LDH), glutamic-oxaloacetic transaminase (SGOT), total lipid, cholesterol, triglyceride, α-lipoprotein, pre-β-lipoprotein and β-lipoprotein) were estimated in 105 pairs of healthy twins of both sexes (57 MZ and 48 DZ) by path analysis. The genotype effect was significant for all traits (P < 0.001) and its value extended from 0.52 (α-lipoprotein) to 0.81 (alkaline phosphatase), whereas environmental effect was significant (P < 0.05) in only 10 traits of the 17 analyzed, with the maximum value of 0.13 (cholesterol). Correlations between genotypes of paired traits were estimated and, of 136 values, 47 were significant at the 5% levels, thus indicating partial and common genetic mechanisms.

Keywords

Path analysisSerum componentsHeritabilityQuantitative genetics
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 1 , January 1983 , pp. 23 - 29
Copyright
Copyright © The International Society for Twin Studies 1983

References

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