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Genetic and Environmental Determinants of 17 Serum Biochemical Traits in Brazilian Twins

Published online by Cambridge University Press:  01 August 2014

Gloria M.D. Dal Colletto ,
Henrique Krieger  and
José Reinaldo Magalhães
Gloria M.D. Dal Colletto*
Affiliation:
Departamento de Biologia, Instituto de Biociências, USP, São Paulo, Brazil
Henrique Krieger
Affiliation:
Centro de Referência Genética, UFSCar, São Carlos, Brazil
José Reinaldo Magalhães
Affiliation:
Departamento de Biofisica, Escola Paulista de Medicina, São Paulo, Brazil
*
Departamento de Biologia, Universidade de São Paulo, Caixa Postal 11461, 05421 São Paulo, SP, Brazil

Abstract

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The genetic and environmental effects on the levels of 17 serum biochemical quantitative traits (calcium, phosphorus, glucose, urea nitrogen, uric acid, total protein, albumin, total bilirubin, alkaline phosphatase, lactate dehydrogenase (LDH), glutamic-oxaloacetic transaminase (SGOT), total lipid, cholesterol, triglyceride, α-lipoprotein, pre-β-lipoprotein and β-lipoprotein) were estimated in 105 pairs of healthy twins of both sexes (57 MZ and 48 DZ) by path analysis. The genotype effect was significant for all traits (P < 0.001) and its value extended from 0.52 (α-lipoprotein) to 0.81 (alkaline phosphatase), whereas environmental effect was significant (P < 0.05) in only 10 traits of the 17 analyzed, with the maximum value of 0.13 (cholesterol). Correlations between genotypes of paired traits were estimated and, of 136 values, 47 were significant at the 5% levels, thus indicating partial and common genetic mechanisms.

Keywords

Path analysisSerum componentsHeritabilityQuantitative genetics
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 1 , January 1983 , pp. 23 - 29
Copyright
Copyright © The International Society for Twin Studies 1983

References

REFERENCES

1.Barbosa, CAA, Abreu, MCA, Krieger, H, Sanz, TA, Luiz, VJ (1981): Family resemblance for total protein and albumin serum concentration (in preparation).Google Scholar
2.Christie, WW (1973): “Lipid Analysis.” London: Pergamon.Google Scholar
3.Colletto, GMDD, Krieger, H, Magalhães, JR (1981): Estimates of the genetical and environmental determinants of serum lipid and lipoprotein concentration in Brazilian twins. Hum Hered 31(4):232–237.CrossRefGoogle Scholar
4.Frey, H, Nauto, V, Kulone, E (1968): Serum proteins in finnish twins. Acta Genet (Basel) 18:23–30.Google ScholarPubMed
5.Havlik, R, Garrison, R, Fabsitz, R, Feinleib, M (1977): Genetic variability of clinical chemical values. Clin Chem 23(4):659–662.Google ScholarPubMed
6.Le Roy Heinrichs, W, Sheltar, MR (1958): Serum glycoproteins in monozygotic an dizygotic twins Proc Soc Exp Biol Med 99:132–133.CrossRefGoogle Scholar
7.Leonhardt, T (1962): The quantitative variations of serum proteins. Electrophoretic studies of twin materials. Acta Genet (Basel) 12:251–261.Google Scholar
8.Lykken, DT, Tellegen, A, DeRubeis, (1978): Volunteer bias in twin research: The rule of two-thirds. Social Biol 25:1–9.Google Scholar
9.Morton, NE (1974): Analysis of family resemblance. I. Introduction. Am J Hum Genet 26:318–330.Google ScholarPubMed
10.Rao, DC, Morton, NE, Yee, S (1974): Analysis of family resemblance. II. A linear model for familial correlation. Am J Hum Genet 26:331–359.Google Scholar
11.Rao, DC, Morton, NE, Yee, S (1976): Resolution of cultural and biological inheritance by path analysis. Am J Hum Genet 28:228–242.Google Scholar
12.Schrott, HG, Bucher, KA, Clarke, WR, Lauer, RM (1979): The Muscatin hyperlipidemia family study program. Prog Clin Biol Res 32:619–646.Google Scholar
13.Wright, S (1921): Correlation and causation. J Agric Res 20:557–585.Google Scholar