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Evaluation of the Granulopoiesis during Antiblastic Treatment*

Published online by Cambridge University Press:  01 August 2014

A. Fieschi  and
C. Sacchetti
A. Fieschi
Affiliation:
Istituto di Patologia Speciale Medica, Università di Genova
C. Sacchetti
Affiliation:
Istituto di Patologia Speciale Medica, Università di Genova

Summary

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Selected subjects have been treated with cyclophosphamide and nitrogen mustard. The granulocytopenia has been followed by repeated in vivo labeling with DFP32 and the endotoxin test for evaluating the availability of the granulocyte reserve. The effect of steroid treatment on the recovery of the granulopoiesis has been studied with autotransfusions of in vitro DFP32 labeled granulocytes in the same subject and performed before, during and after the treatment was discontinued.

The following conclusions have been reached:

1. The efficiency of the granulopoiesis is based upon the availability of the bone marrow granulocyte reserve.

2. The bone marrow granulocyte mobilization with endotoxin and the in vivo granulocyte labeling with DFP32 give an evaluable information about the bone marrow granulocyte reserve.

3. The granulocytopenia due to antiblastic therapy corresponds to a depletion of the bone marrow granulocyte reserve.

4. The recovery of a “normal granulocyte count” preceeds the rebuilt of a “normal availability” of the bone marrow granulocyte reserve.

5. The recovery of the blood granulocyte count after prednison is not associated with any favourable change of the granulopoiesis.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 18 - 29
Copyright
Copyright © The International Society for Twin Studies 1967

Footnotes

*

Researches supported by G.N.R. (National Research Council); grant no. 2252/65 for 1962 and no. 4l/79/4/3719 for 1964.

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