Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-26T13:15:30.541Z Has data issue: false hasContentIssue false
  • English
  • Français

Essential Isochronic Epilepsy in MZ Twin Pairs

Published online by Cambridge University Press:  01 August 2014

L. Gedda  and
R. Tatarelli
L. Gedda
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Studies, Rome
R. Tatarelli
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Studies, Rome

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A total of 45 twin pairs (19 MZ and 26 DZ), with one or both members affected by essential Generalized Epileptic Attacks, have been drawn out of the Mendel Institute's twin file. Concordance was observed in 18: 19 MZ, but only in 3: 26 DZ twin pairs.

Analysis of the 18 MZ concordant twin pairs has shown (1) concordance of clinical form in 17 pairs, (2) concordance in the age of onset in 15 pairs, and (3) concordance of expression (frequency of generalized attacks) in 13 pairs.

Riassunto

RIASSUNTO

Dalla cartoteca dell'Istituto Mendel sono state ricavate 45 coppie di gemelli, 19 MZ e 26 DZ, con uno o ambedue i cogeraelli affetti da Attacchi Epilettici Generalizzati essenziali. È stata riscontrata concordanza in 18: 19 coppie MZ e solo in 3: 26 coppie DZ.

L'analisi delle 18 coppie MZ concordanti ha rilevato inoltre: (1) concordanza di forma clinica in 17 coppie, (2) concordanza dell'età di insorgenza in 15 coppie e (3) concordanza di espressione (frequenza di attacchi generalizzati) in 13 coppie.

Résumé

RÉSUMÉ

Un échantillon de 45 couples de jumeaux (19 MZ et 26 DZ), dont l'un ou les deux membres atteints de Attaques Epileptiques Généralisées essentielles, a été tiré du registre gémellaire de l'Institut Mendel. La maladie était concordante chez 18: 19 couples MZ et seulement chez 3: 26 couples DZ.

L'analyse des 18 couples MZ concordants a aussi démontré: (1) concordance de forme clinique chez 17 couples, (2) concordance de l'âge de début chez 15 couples et (3) concordance d'expression (fréquences des attaques généralisées) chez 13 couples.

Zusammenfassung

ZUSAMMENFASSUNG

Aus der Kartothek des Mendel-Institutes wurden 45 Zwillingspaare gewählt (19 EZ und 26 ZZ), von denen einer oder beide an allgemeinen essentiellen epileptischen Anfällen litten. Bei den EZ betrug die Konkordanz 18:19 bei den ZZ-Paaren nur 3:26.

Eine Analyse der 18 konkordanten EZ-Paare ergab ausserdem: (1) bei 17 Paaren eine Konkordanz der klinischen Form, (2) bei 15 Paaren Konkordanz des Auftrittsalters und (3) bei 13 Paaren Konkordanz der Ausdrucksform (Frequenz der allgemeinen Anfälle).

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 20 , Issue 4 , October 1971 , pp. 380 - 383
Copyright
Copyright © The International Society for Twin Studies 1971

References

Braconi, M. (1962). La ricerca gemellologica nell'epilessia. Acta Genet. Med. Gemellol., 11: 138–157.CrossRefGoogle Scholar
Braconi, L. (1963). L'epilessia come espressione di un tratto ereditario. Proc. 2nd Int. Congr. Hum. Genet., Roma.Google Scholar
Conrad, C. (1940). Die erbliche Fallsucht. Handbuch der Erbkrank. Thieme Verlag, Leipzig.Google Scholar
Gedda, L. (1951). Lo Studio dei Gemelli. Ed. Orizzonte Medico, Roma.Google Scholar
Gedda, L., Brenci, G. (1969). Biology of the gene: the ergon/chronon system. Acta Genet. Med. Gemellol., 18: 329–379.Google Scholar
Kimball, O. P. Hersh, A. H. (1955). The genetics of epilepsy. Acta Genet. Med. Gemellol., 4: 131.Google Scholar
Lennox, W. G., Gibbs, E. L., Gibbs, F. A. (1940). Inheritance of cerebral dysrythmia and epilepsy. Arch. Neurol. Psychiatr., 44: 1155.Google Scholar
Rosanoff, J., Handy, L. M., Rosanoff, I. A. (1931). Etiology of epilepsy. Arch. Neurol. Psychiat., 31: 1165.Google Scholar
Vogel, F. (1965). Genetic aspects of the EEG. EEG Clin. Neurophysiol., 19: 196.Google Scholar