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Effects of Melphalan on a Sensitive and a Resistant Yoshida Ascites Tumour

Published online by Cambridge University Press:  01 August 2014

E. H. Cooper  and
Norma E. Topping
E. H. Cooper
Affiliation:
Chester Beatty Res. Inst., Institute of Cancer Research, Royal Cancer Hospital, London
Norma E. Topping
Affiliation:
Chester Beatty Res. Inst., Institute of Cancer Research, Royal Cancer Hospital, London

Summary

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The mode of action of the alkylating agent Melphalan on Yoshida ascites tumours resistant and sensitive to alkylating agents in rats has been studied. A combination of autoradiography and analytical histochemistry has been used to measure changes in the cell kinetics. The sensitive strain showed a marked fall in mitotic index, build up in G2 and finally interphase death occurring 24-72 hours after treatment. The resistant form showed only slight mitotic inhibition and a possible recovery phase 24-30 hours after treatment, without evidence of cytological damage.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 40 - 50
Copyright
Copyright © The International Society for Twin Studies 1967

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