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Down's Syndrome with Familial G/G Translocation

Published online by Cambridge University Press:  01 August 2014

K. Méhes
K. Méhes*
Affiliation:
Dept. of Pediatrics, University Medical School, Pécs, Hungary
*
Dept. of Pediatrics, University Medical School, Pécs, Hungary

Summary

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Cytogenetic examinations of a 7/12-year-old girl and her parents revealed a familial G/G translocation.

46 chromosomes in the mitoses of the mongoloid child and only 45 chromosomes in those of the apparently normal father could be observed. The analysis of karyotypes revealed a balanced G/G translocation in the father and a G/G translocation mongolism in the probanda. Dermatoglyphic patterns of both the child and her father showed some features characteristic of Down's syndrome.

The mother's karyotype proved to be normal (46, XX).

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 18 , Issue 1 , January 1969 , pp. 86 - 91
Copyright
Copyright © The International Society for Twin Studies 1969

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