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Down's Syndrome and Maternal Inbreeding*

Published online by Cambridge University Press:  01 August 2014

Ei Matsunaga
Ei Matsunaga*
Affiliation:
Dept. of Human Genetics, National Institute of Genetics, Mishima (Nippon)

Summary

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In order to test the possible effect of maternal inbreeding upon non-disjunction, ancestors of 104 children with Down's syndrome born to younger mothers were identified on the basis of official records. Among them, 6 had related parents, while 10 of the fathers and 12 of the mothers had also such parents. The relationship comprises first-cousins, first-cousins once removed, and second cousins. It was concluded that recessive genes are unlikely to be involved in the aetiology of non-disjunction of the 21st autosome, at least in younger mothers.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 15 , Issue 3 , July 1966 , pp. 224 - 230
Copyright
Copyright © The International Society for Twin Studies 1966

Footnotes

*

This paper is dedicated to Professor Dr. O. Frhr. von Verschuer in honour of his seventieth birthday. Contribution no. 618 from the National Institute of Genetics, Japan.

References

Forssman, H., Åkesson, H. O. (1966). Consanguineous Marriages and Mongolism. The Study Group on Mongolism. The Ciba Foundation, London.Google Scholar
Gowen, J. W. (1933). Meiosis as a genetic character in Drosophila melanogaster . J. Exp. Zool., 65: 83–106.Google Scholar
Hamerton, J. L. et al. (1965). Cytogenetics of Down's syndrome (Mongolism). I. Data on a consecutive series of patients referred for genetic counselling and diagnosis. Cytogenetics, 4: 171–185.Google Scholar
Kamada, N. et al. (1965). Cytogenetic studies on Down's syndrome in Hiroshima and Nagasaki. Proc. Tenth Ann. Meet. Jap. Soc. Hum. Genet., Kumamoto, 10 9-10, (in Japanese).Google Scholar
Matsunaga, E. (1966). Parental age, live-birth order and pregnancy free interval in Down's syndrome in Japan. The Study Group on Mongolism. The Ciba Foundation, London.Google Scholar
Penrose, L. S. (1933). The relative effects of paternal and maternal age in mongolism. J. Genet., 27: 219–224.CrossRefGoogle Scholar
Penrose, L. S. (1961). Mongolism. Brit. Med. Bull., 17: 184–189.CrossRefGoogle ScholarPubMed
Sigler, A. T. et al. (1965). Parental age in Down's syndrome (mongolism). J. Pediat., 631–642.Google Scholar
Tonomura, A. et al. (1965). Cytogenetic studies of 100 cases of Down's syndrome. Proc. Tenth Ann. Meet. Jap. Soc. Hum. Genet., Kumamoto, 10 9-10, (in Japanese).Google Scholar