Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-22T20:26:13.965Z Has data issue: false hasContentIssue false
  • English
  • Français

Dissimilar Effects of Thalidomide in Dizygotic Twins

Published online by Cambridge University Press:  01 August 2014

Márcia Schmidt  and
Francisco M. Salzano
Márcia Schmidt
Affiliation:
Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Francisco M. Salzano*
Affiliation:
Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
*
Departamento de Genética, Instituto de Biociências, UFRGS Caixa Postal 1953, 90000 Porto Alegre, RS, Brazil

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Among 93 cases of thalidomide embryopathy ascertained in Brazil, one pair of female dizygotic twins was found. One of them presented complete paraxial hemimelia in the right arm while the other showed a triphalangeal thumb at the left hand and had duodenal stenosis. Of the eight dizygotic twin pairs exposed to thalidomide in utero described thus far, only four were concordant for the type of malformation.

Keywords

ThalidomideEmbryopathyTeratogenesisTwins
Type
Case Report
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 4 , October 1980 , pp. 295 - 297
Copyright
Copyright © The International Society for Twin Studies 1980

References

REFERENCES

1. Lenz, W (1966. Malformations caused by drugs in pregnancy. Am J Dis Child 112:99–106.Google ScholarPubMed
2. Meilin, GW, Katzenstein, M (1962. The saga of thalidomide. Neuropathy to embryopathy with case reports of congenital anomalies. N Engl J Med 267:1184–1193.CrossRefGoogle Scholar
3. Pfeiffer, RA, Kosenow, W (1962. Thalidomide and congenital abnormalities. Lancet 1:45–46.Google Scholar