Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-26T15:47:40.089Z Has data issue: false hasContentIssue false

Depression, Criminality and Psychopathology Associated with Alcoholism: Evidence from a Twin Study

Published online by Cambridge University Press:  01 August 2014

H.M.D. Gurling*
Affiliation:
Genetics Section, Institute of Psychiatry, University of London
B.E. Oppenheim
Affiliation:
Genetics Section, Institute of Psychiatry, University of London
R.M. Murray
Affiliation:
Genetics Section, Institute of Psychiatry, University of London
*
Genetics Section, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, U.K.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A study of 74 twin pairs with alcoholic probands from the Maudsley Hospital is reported. Pairwise concordance for alcoholism as categorised by the SADS-L Research Diagnostic Criteria is similar in MZ twins (29%, 8/22) and DZ twins (33%, 13/39). Concordance for all diagnoses other than alcoholism is however significantly greater in MZ twins (48%, 13/27) than DZ twins (21%, 8/39, P < 0.001). Concordance in MZ and DZ twins for all diagnoses other than alcoholism, inlcuding depression, did not coincide with concordance for alcoholism. Data on criminality revealed that 21% (32/148) of the twin sample had non-alcohol, non-traffic offences on record at the UK Home Office. Of the 32 with criminal records, 28 were alcoholic probands and pairwise concordance for criminality was found in only 1 MZ and 2 DZ pairs.

Type
Genetics of Psychopathology
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1.Bohman, M, Sigvardsson, S, Cloninger, R (1981): Maternal inheritance of alcohol abuse. Cross fostering analysis of adopted women. Arch. Gen. Psychiatry 38:965969.CrossRefGoogle ScholarPubMed
2.Caetano, R, Edwards, G, Oppenheim, AN, Taylor, C (1978): Building a standardised alcoholism interview schedule. Drug and Alcohol Dependence, 3:185197.Google Scholar
3.Clifford, CA (1982): Twin Studies of Drinking Behaviour and Obsessionality. PhD. Thesis, Institute of Psychiatry, University of London.Google Scholar
4.Cloninger, CR, Bohman, M, Sigvardsson, S (1981): Inheritance of alcohol abuse. Cross fostering of adopted men. Arch Gen Psychiatry 8:861868.Google Scholar
5.Cotton, NS (1979): The familial incidence of alcoholism. A review. Journal of Studies on Alcohol 40:89115.CrossRefGoogle ScholarPubMed
6.Ewards, G, Gross, MM, Keller, M, Moser, J, Room, R (1977): Alchol-related disabilities. World Health Organisation, Geneva.Google Scholar
7.Goodwin, DW, Schulsinger, F, Hermansen, L, Guze, SB, Winokur, G (1973): Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch Gen Psychiatry 28:238243.CrossRefGoogle ScholarPubMed
8.Gurling, HMD, Murray, RM, Clifford, CA (1981): Investigations into the genetics of alcohol dependence and into its effects on brain function. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part C, Epidemiological and Clinical Studies. New York: Alan R Liss, p 7787.Google Scholar
9.Harada, S, Misawa, S, Agarwal, DP, Goedde, HW (1980): Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: Isozyme variation and its possible role in alcohol intoxication. Am J Hum Genet 32:815.Google Scholar
10.Hrubec, Z, Omenn, GS (1981): Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcoholism: Clinical and Experimental Research 5:207212.Google Scholar
11.Kaij, L (1960): Alcoholism in Twins. Stockholm: Almqvist and Wiksell.Google Scholar
12.Murray, RM, Clifford, CA, Gurling, HMD (1983): Twin and adoption studies: how good is the evidence for a genetic role? In Galanter, E (ed): Current Research in Alcholism. New York: Academic Press.Google Scholar
13.Murray, RM, Clifford, CA, Gurling, HMD, Topham, A, Clow, A, Bernadt, M (1983): Current genetic and biological approaches to alcoholism. Psychiatric Develoopments 2:179192.Google Scholar
14.Schuckit, MA, Goodwin, DA, Winokur, G (1972): A study of alcoholism in half siblings. Am J Psychiatry 128:1132–6.CrossRefGoogle ScholarPubMed
15.Slater, E, Shields, J (1969): Genetical aspects of anxiety in studies of anxiety. In Lader, M (ed): Br J Psychiatry Special Publication No. 3. Headley Bros.Google Scholar
16.Spitzer, RL (1978): Critical Issues in Psychiatric Diagnosis. New York: Raven Press.Google Scholar