Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-26T23:44:00.288Z Has data issue: false hasContentIssue false
  • English
  • Français

The Contribution of the « Clinical Twin Method » to the Study of Sex Anomalies in Childhood* (Phimosis, hypospadias, cryptorchism, adiposogenital dystrophy Laurence-Moon-Bardet-Biedl syndrome)

Published online by Cambridge University Press:  01 August 2014

L. Gedda  and
F. Di Raimondo
L. Gedda
Affiliation:
Istituto di Genetica Medica e Gemellologia « G. Mendel », Roma, (Italia)
F. Di Raimondo
Affiliation:
Istituto di Genetica Medica e Gemellologia « G. Mendel », Roma, (Italia)

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

First of all the Authors stress the importance of twin studies as a method of analysis of the pathological phenomena from a hereditary standpoint: to this aim, the Interzygotic Twin Method may be used in statistical studies, and the Clinical Twin Method in clinical ones. On this basis, the Authors report their observations, on a remarkable number of male twin pairs, affected by anomalies or syndromes including one or more genital dysfunctions, either in infancy or adolescence. Numerous cases of phimosis are thus presented, where the higher concordance in pairs of MZ twins stands for a hereditary conditioning; cases of hypospadias, showing a perfect symmetry of the malformation in the cotwins; cryptorchism, with various possibilities of presentation of the anomaly in the intrageminal comparison. The Authors also describe in detail, making an analytical intra-pair comparison of the symptoms and laboratory data, some cases of complex adiposogenital dystrophy, as well as one case of Laurence-Moon-Bardet-Biedl syndrome with different clinical manifestation in a DZ pair. The longitudinal study carried out over many years on some of the pairs affected by the above mentioned clinical pictures, and the clinico-statistical analysis of the cases under consideration allow the Authors to draw a number of positive conclusions concerning the variable, genotypic conditioning of the sex anomalies considered: in this field, as well as in many others of nosography, the Clinical Twin Method appears to be highly useful in practice, and unique by reason of its peculiarity.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 13 , Issue 3 , July 1964 , pp. 217 - 239
Copyright
Copyright © The International Society for Twin Studies 1964

Footnotes

*

Lecture read at the Symposium on « Sex Pathology in Childhood » held at Perugia (Italy) on May 9-11, 1964.

References

1. Balavoine, C.: Discordances multiples chez deux jumeaux univitellins. J. Génét. hum. vol. 3, pp. 71–79, 1954.Google Scholar
2. Billingham, R. E., Lampkin, G. H., Medawar, P. B. & Williams, H. LL.: Tolerance to homografts, twin diagnosis, and the Freemartin condition in cattle. Heredity, vol. 6. Part. 2, pp. 201–212 (1952).Google Scholar
3. Birkenfeld, W.: Kryptorchismus und Leistenbruch bei eineiigen Zwillingen. Deutsche med. Wchnschr. 55, I, 1043–1044 (1929).CrossRefGoogle Scholar
4. Roberto, Burgio G.: Per una classificazione patogenetica delle affezioni del sesso nell'età infantile. La Pediatria, LXXI, IV, 525–554, 1963.Google Scholar
5. Brauns, L.: Studien an Zwillingen im Säuglings- und Kleinkindesalter. Ein Beitrag zur Zwillingsbiologie. Ztsch. f. Kinderforsch. 43, 2, 86–129 (1934).Google Scholar
6. Camerer, Y. W.: Diskordantes Vorkommen einer Hypospadie bei einem eineiigen Zwillingspaar. Erbarzt 5 (1938).Google Scholar
7. Charny, C. W. and Wolgin, W.: Cryptorchism, New York, Hoeber-Harper, 1957.Google Scholar
8. Curtius, F. und Korkhaus, G.: Klinische Zwillingsstudien. Ztschr. f. Konstitutionslehre, 15, 2, 229–267 (1930).Google Scholar
9. Davidson, I., Newberger, C.: Congenital valves of the posterior urethra in twins. Arch. Path. (Chicago) 1933, 16, 57–62.Google Scholar
10. Gedda, L.: On the statistical significance of one pair of monozygotic twins in clinical genetics. A. Ge. Me. Ge., XII, 4, 10 (1963) 317–323.Google Scholar
11. Gedda, L.: De Genetica Medica - Edizioni Istituto Mendel - Roma, 1961–1964.Google Scholar
12. Gedda, L.: e Rovigatti, : in Gedda: Studio dei gemelli. Roma, Orizzonte Medico, 1951, p. 940.Google Scholar
13. Glass, S. J.: Bilateral cryptorchism in identical twins. J. Clin. Endocr. 6, 6, 797–801 (1946).Google Scholar
14. Goll, H., und Kahlich-Koenner, D. M.: Akrocephalosyndaktylie mit Spalthand bei einem Partner eines eineiigen Zwillingspaares. Ztschr. f. menschl. Vererb, u. Konstitutionslehre 24, 4, 616–535 (1940).Google Scholar
15. Gregg, N. McA.: Trans. Ophthal. Soc. Aust. 3, 35 (1941).Google Scholar
16. Greene, J. S.: Atypical laryngeal and vocal changes in adolescence. J.A.M.A. 120, 15, 119 (1942).Google Scholar
17. Guckeisen, P.: Dystrophia adiposogenitalis bei eineiigen Zwillingen. Diss. München, pp. 27 (1940).Google Scholar
18. Guilleminet, M., Bertoye, A., et Jacquet, J.: Intervention chirurgicale chez deux jumeaux monozygotes pour maladie de Little. Lyon chir. 43, 4, 500–503 (1948).Google Scholar
19. Harnack, G. A., von Horst, W., Lenz, W. u., Zukschwerdt, L.: Homotransplantation von Schilddrüsengewebe bei einem eineiigen Zwillingspaar, Deutsche Med. Woch. 83, 14, 549–555 (1958).Google Scholar
20. Kermauner, : Fehlbildungen des weiblichen Genitales. Halban-Seitz'. Biologie und Pathologie des Weibes 3. 514 (1924).Google Scholar
21. Klein, D., Ferrier, P., et Ammann, F.: La génétique de l'ectopie testiculaire. Pathologie Vol. II, nn. 21-22, 11 1963, pp. 1214–1221.Google Scholar
22. Lamy, M.: Lecture read at the University Institute of Human Genetics, Copenhagen 04 18, 1952.Google Scholar
23. Lehmann, W.: Hypospadie bei einem eineiigen Zwillingspaar. Erbarzt. 3, 10, 5, 147 (1936).Google Scholar
24. Luth, : Störungen bei eineiigen Zwillingen. Ztsch. f. menschl. Vererb, u. Konstitutionslehre 21, 1, 55–56 (1937).Google Scholar
25. Moench, A.: Laurence-Moon-Biedl syndrome. Proc. Roy. Soc. Med. 44, 1063, 1951.Google Scholar
26. Parhon, C. I. et Simian, J.: Cryptorchidie unilatérale gauche chez deux jumeaux âgés de 5 ans. Bull. Sect. Endocrin. Soc. Roum. Neur. etc. 3, 44–46 (1937).Google Scholar
27. Pfister, A.: Beobachtungen an eineiigen Zwillingspaaren. Arch. Klaus. Stift. Vererb. Forsch. 1937, 12, 578–629.Google Scholar
28. Rumpel, : Hypospadie bei Zwillingen. Frankfurt. Ztschr. f. Path. 25, 53 (1921).Google Scholar
29. Sacrez, , Rohmer, , Bronner, , Heitzmann, : Syndrome de Laurence-Bardet-Biedl chez deux jumeaux. Soc. Péd. de l'Est. 04 1947. Presse méd. 54, 616 (1947).Google Scholar
30. Schumacher, J.: Dystrophia adiposogenitalis der eineiigen Zwillingen. Erbarzt 7–8, 167–184 (1940).Google Scholar
31. Siemens, H. W.: Die Zwillingspathologie, ihre Bedeutung, ihre Methodik, ihre bisherigen Ergebnisse. J. Springer, Berlin (1924).Google Scholar
32. Sørensen, H. R.: Hypospadias. København, Einar Munksgaard, 1953.Google Scholar
33. Steiner, : Zur Erblichkeit der Hypospadia. München, mediz. Wochenschr. II, 1936.Google Scholar
34. Turpin, R.: Contribution à la pathologie des jumeaux. Semaine Hôp. de Paris 19, 501–507 (1938).Google Scholar
35. Turpin, R., Tisserand, M. et Sans, R.: Les chondro-épiphysites des jumeaux. Rev. franç. de Pédiat. 15, 6, 429–499 (1939–1940).Google Scholar
36. Verschuer, O. v.: Erbpathologie, Steinkopff, 1937, p. 135.Google Scholar
37. Verschuer, O. v.: Z. menschl. Vererb. u. Konstitutionslehre, 33, 316, 1956.Google Scholar
38. Voute, P. A.: Hypospadia penis bij een eeneiigen tweeling. Nederl. Tijdschr. v. Geneesk. 77, 21, 2431–2433 (1933).Google Scholar
39. Werner, B.: Dtschr. med. Wchnschr. 55, 1043 (1929).Google Scholar
40. Woodruff, M. F. A. and Lennox, B.: Reciprocal skin grafts in a pair of twins showing blood chimaerism. Lancet (1959), 2, 476–78.Google Scholar