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Considerazioni su un caso di due Gemelle Monozigotiche affette da Anemia Drepanocitica

Published online by Cambridge University Press:  01 August 2014

L. Perosa ,
M. Ramunni ,
G. Manganelli  and
L. Bini
L. Perosa
Affiliation:
Istituto di Clinica Medica dell'Università di Bari, (Direttore Prof. V. Chini)
M. Ramunni
Affiliation:
Istituto di Clinica Medica dell'Università di Bari, (Direttore Prof. V. Chini)
G. Manganelli
Affiliation:
Istituto di Clinica Medica dell'Università di Bari, (Direttore Prof. V. Chini)
L. Bini
Affiliation:
Istituto di Clinica Medica dell'Università di Bari, (Direttore Prof. V. Chini)

Summary

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The Authors describe the case of homozygous twins affected by sickle-cell anemia. The patients were physically similar and showed identical haematological findings. One of them had suffered often of severe sicklemic crisis during one of these appeared also a noticeable neurological complication.

Therefore the Authors discuss the pathogenesys of sickle-cell anemia according to the modern views.

Riassunto

Riassunto

Gli A.A. descrivono il caso di due gemelle monozigotiche affette da anemia drepanocitica. Le due gemelle presentavano non solo una perfetta somiglianza fisica ma anche un identico reperto ematologico. Una sola delle due gemelle però aveva più volte sofferto di gravi « crisi » falcemiche; durante una di queste era comparsa inoltre una grave complicazione neurologica. Gli A.A. pertanto prendono lo spunto per discutere, alla luce delle moderne acquisizioni, la patogenesi delle « crisi » falcemiche.

Résumé

RÉSUMÉ

Les AA. décrivent un cas de deux jumelles monozygotiques atteintes d'anémie drépanocytique. Les deux jumelles se ressemblaient tout-à-fait entr'elles et davantage montraient le même cadre hématologique. Une d'elles avait souffert beaucoup de fois par des poussées falcémiques aiguës; pendant une de ces poussées il est arrivé une grave complication neurologique.

Les AA. prennent l'occasion pour discuter, à la lumière des modernes connaissances, la pathogénie des « poussées » falcémiques.

Zusammenfassung

ZUSAMMENFASSUNG

Die Autoren beschreiben den fall der homozigotischen Zwillinge, die an Drepanocytaemie leiden. Die zwei Zwillinge sind nicht nur Koerperlich aehnlich sondern zeigen auch dasselbe ematologische Bild auf. Nur eines der beiden Zwillinge hatte mehrmals unter schweren Krisen der Drepanocytaemie zu leiden gehabt: waehrend einer dieser Krisen ist eine schwere neurologische Komplikation aufgetreten.

Die Autoren legen dies zugrunde um, beim Lichte moderner Kenntnisse, ueber die Patogenesis der drepanocytischen Krisen zu diskutieren.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 8 , Issue 1 , January 1959 , pp. 87 - 98
Copyright
Copyright © The International Society for Twin Studies 1959

References

Bibliografia

1. Anastasopoulos, G., Diakoghiannis, A. e Rutsonis, : Min. Med., 1, 843, 1956.Google Scholar
2. Bauer, J. Arch. Surg., 41, 1344, 1940.Google Scholar
3. Beet, E. A. Ann. Eugen., 14, 279, 1949.Google Scholar
4. Bessis, M., Bricka, M., Breton-Gorius, J. e Tabuis, J. Blood, 9, 39, 1954.Google Scholar
5. Bloch, E. H., Powell, A., Peryman, H. T., Warner, L., e Kafig, E. Angiology, 7, 479, 1956.CrossRefGoogle Scholar
6. Bridgers, W. H. Am. J. Pathol., 15, 353, 1939.Google Scholar
7. Bunting, H. Am. J. Med. Sc. 198, 191, 1939.Google Scholar
8. Chernoff, A. J. e Josephson, A. M. Am. J. Dis. Child., 82, 310, 1951.Google Scholar
9. Connell, J. H.: J. Am Med. Ass., 118, 893, 1942.Google Scholar
9 bis. De Matteis, F.: Rec. Progressi in Medicina, 18, 457, 1955.Google Scholar
10. Dickstein, B.: Am. J. Med. Sc., 224 679, 1952.Google Scholar
11. Diggs, L. W. e Ching, R. E.: cit. in 21Google Scholar
12 Diggs, L. W. e Ching, R. E.: Am. J. Clin. Pathol., 26, 1109, 1956.Google Scholar
13. Fahraeus, R.: Acta Med. Scandin., 55, 3, 1921.Google Scholar
14. Galton, F.: cit. in 15.Google Scholar
15. Gedda, L.: Studio dei gemelli, Ed. Orizzonte Medico, Roma 1951.Google Scholar
16. Green, T. W. e Conley, C. L.: Ann. Int. Med., 34, 849, 1951.Google Scholar
17. Harris, J. W. Brewster, H. H., Ham, T. H., e Castle, W. B.: Arch. Int. Med. 97, 145, 1956.Google Scholar
18. Henderson, A. B.: Am. J. Med. Sc., 221, 628, 1951.Google Scholar
19. Hirsohboeck, J. S. e Woo, M.: Am. J. Med. Sc. 219, 538, 1950.Google Scholar
20. Hughes, J. H., Diggs, L. W. e Gillespie, C. E.: J. of Pediatries, 17, 166, 1940.Google Scholar
21. Kimmelstiel, P.: Am. J. Med. Sc. 216, 11, 1948.CrossRefGoogle Scholar
22. Knisely, M. H., Stratman-Thomas, W. K. e Eliot, T.: cit. in 19.Google Scholar
23. Knisely, M. H., Bloch, E. H., Elion, T. S. e Warner, L.: Science 106, 431, 1947.CrossRefGoogle Scholar
24. Knisely, M. H., Bloch, E. H., Brooks, F. e Warner, L.: Am. J. Med. Sc. 216, 249, 1950.CrossRefGoogle Scholar
25. Leavell, B. S.: Arch. Int. Med. 98, 801, 1954.Google Scholar
26. Leivy, F. E. e Schnabe, T. G.: Am. J. Med. Sc. 183, 381, 1932.Google Scholar
27. Mallorg, T.: cit. in 21.Google Scholar
27 bis. Marmont, A., Fusco, F. e Mariotti, L.: Progresso Medico, 12, 429, 1956.Google Scholar
28. Murphy, R. C., e Shapiro, S.: cit. in 21.Google Scholar
29. Neel, J. V.: Genetiecs 32, 38, 1947.Google Scholar
30. Neel, J. V.: Blood 6, 389, 1951.CrossRefGoogle Scholar
31. Pratt-Thomas, H. R. e Switzer, P. K.: South. Med. J. 42, 376, 1949.CrossRefGoogle Scholar
32. Robertsoon, H. S., Wolf, S. e Wolf, H. S.: Am. J. Med. Sc. 219, 534, 1950.Google Scholar
33. Rudner, H. G. Jr. e Rudner, H. G. Jr.: Am. J. Gastroenterol. 25, 11, 1956.Google Scholar
34. Singer, K., Motulsky, A. G. e Wile, S. A.: J. Lab. a. Clin. Med. 33, 721, 1950.Google Scholar
35. Tomylinson, W. J.: Am. J. Med. Sc. 209, 722, 1945.Google Scholar
36. Wade, L. J. e Stevenson, L. D.: cit. in 21.Google Scholar
37. Watson, R. J.: Bull. New York Acad. Med. 30, 106, 1954.Google Scholar
38. Wintrobe, M. M.: Clinical Hematology, Lea e Febiger Ed., Philadelphia 1951.Google Scholar
39. Yater, W. M. e Hansmann, G. H.: Am. J. Med Sc., 191, 474, 1936.CrossRefGoogle Scholar