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Congenital Malformations, Twinning and Associated Variables in a Brazilian Population

Published online by Cambridge University Press:  01 August 2014

Aldo M. De Araújo  and
Francisco M. Salzano
Aldo M. De Araújo
Affiliation:
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Francisco M. Salzano*
Affiliation:
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
*
Departamento de Genética, Instituto de Biociências, Universidade Federal do RGS, Caixa Postal 1953, 90000 Porto Alegre, RS, Brazil

Abstract

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A sample of 6052 newborn children (4968 whites, 1084 Blacks) issued from parents with a generally low socioeconomic level, was studied in relation to congenital anomalies and twinning rates.

The observed frequency of major malformations was 1.3% and of minor defects 2.0%. The twinning rate was 1.4%. Race differences were generally nonsignificant in these variables. These results are in agreement with those obtained in some other Brazilian series, but discrepancies were also observed.

A total of 13%0 of the malformations observed proved to be familial, Polydactyly being the most common anomaly encountered in this class. The frequency of malformations different from those present in the propositi is higher in their sibships than the general prevalence of defective children found among the sibs of normal babies (13% and 4% respectively).

Age, gestation length and exposure of the mothers to noxious agents during pregnancy were not significantly different when the parents of normal and malformed children were compared. On the other hand, as expected, the parents of twins are significantly older than those of single-born, and the gestation length was much reduced in pregnancies resulting in multiple births.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 31 - 39
Copyright
Copyright © The International Society for Twin Studies 1975

References

REFERENCES

Araújo, A.M., Salzano, F.M. 1974. Marital distances and inbreeding in Porto Alegre, Brazil. Soc. Biol., 21: 249–255.Google Scholar
Araújo, A.M., Salzano, F.M. 1975. Parental characteristics and birthweight in a Brazilian population. Hum. Biol., 47: 37–43.Google Scholar
Araújo, J. 1963. Malformações congênitas. Ped. Prat., 34: 131–138.Google Scholar
Arena, J.F.P. 1974. Estudo clinico-epidemiológico prospectivo das anomalias congênitas na população de Campinas, S.P. Ph. D. Thesis, University of Campinas, S.P., Brazil.Google Scholar
Bulmer, M.G. 1970. The Biology of Twinning in Man. Oxford: Clarendon Press.Google Scholar
Kennedy, W.P. 1967. Epidemiologic aspects of the problem of congenital malformations. Birth Defects, 3: 1–18.Google Scholar
Marden, P.M., Smith, D.W., Mc Donald, M.J. 1964. Congenital anomalies in the newborn infant, including minor variations. J. Pediatr., 64: 357–371.Google Scholar
Neel, J.V. 1958. A study of major congenital defects in Japanese infants. Am. J. Hum. Genet., 10: 398–445.Google Scholar
Niswander, J.D., Adams, M.S. 1968. Major malformations in relatives of oral cleft patients. Acta Genet. (Basel), 18: 229–240.Google Scholar
Pedreira, C.M., Peixoto, L.I.S., Rocha, L.M.G.I. 1959. Estudo da gemelaridade na população de Salvador-Bahia. Anais I Reunião Bras. Genet. Hum., Curitiba, pp. 137–140.Google Scholar
Saldanha, P.H., Cavalcanti, M.A., Lemos, M.L. 1963. Incidência de defeitos congênitos na população de São Paulo. Rev. Paul. Med., 63: 211–229.Google Scholar
Schull, W.J., Neel, J.V. 1965. The Effects of Inbreeding on Japanese Children. New York: Harper and Row.Google Scholar
Souza, J.P., Andrade, A.M.T.L., Ronzani, D.M., Guimarães C.S., David J.A. 1966. Estudo esta tistico do parto gemelar. Rev. Ginec. Obstetr., 119: 68–87.Google Scholar
Stevenson, A.C., Johnston, H.A., Stewart, M.I.P., Golding, D.R. 1966. Congenital malformations. A report of a study of series of consecutive births in 24 centres. Bull. WHO (Suppl.), 34: 1–27. Google ScholarPubMed
Susanne, C., Corbisier, J.V. 1969. Les naissances gémellaires en Belgique (1960-1961) - Etude statistique. Acta Genet. Med. Gemellol. (Roma), 18: 294–320.CrossRefGoogle Scholar