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Congenital Anomalies in Twins in Northern Ireland. III: Anomalies of the Cardiovascular System, 1974-1978

Published online by Cambridge University Press:  01 August 2014

J. Little  and
N.C. Nevin
J. Little*
Affiliation:
Department of Community Medicine and Epidemiology, University of Nottingham, England
N.C. Nevin
Affiliation:
Department of Medical Genetics, Queen's University of Belfast, Northern Ireland
*
Department of Community Medicine and Epidemiology, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK

Abstract

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Rates of congenital anomalies of the cardiovascular system were compared between twins and singletons in a population-based study in Northern Ireland during the period 1974-1978. Multiple sources of ascertainment were used. As in previous studies, the rate of anomalies of the cardiovascular system in twins (91.0/10,000) was higher than the rate in singletons (66.4/10,000). The excess was confined to twins from pairs of like sex and, in the main, anomalies of the circulatory system other than of the heart itself were involved. Problems in the interpretation of this excess are discussed. No twins were concordant for congenital cardiovascular anomalies of any type.

Keywords

Congenital anomaliesCardiovascular diseaseTwinningAscertainment
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 38 , Issue 1-2 , April 1989 , pp. 27 - 35
Copyright
Copyright © The International Society for Twin Studies 1989

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