Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-23T04:41:06.025Z Has data issue: false hasContentIssue false
  • English
  • Français

Blood Uric Acid Level and IQ: A Study in Twin Families

Published online by Cambridge University Press:  01 August 2014

E. Inouye ,
K.S. Park  and
A. Asaka
E. Inouye*
Affiliation:
Institute of Brain Research, University of Tokyo School of Medicine Institute for Developmental Research, Kasugai, Aichi, Japan
K.S. Park
Affiliation:
Sungshin Women's University, Seoul, Korea
A. Asaka
Affiliation:
Department of Mental Health, University of Tokyo School of Medicine
*
Institute for Developmental Research, Kamiyacho, Kasugai, Aichi 480-03, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Applying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (ρ) was approximately 0.1, and variance due to common familial environment (VEC/Vp) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, ρ being 0.34 and 0.04, and VEC/Vp being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p < 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.

Keywords

Uric acidTwin familyHeritabilityAssortative matingCommon familial environmentIQ
Type
Twins and Mental Abilities
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 2 , April 1984 , pp. 237 - 242
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1.Anumonye, A, Pharm, D, Dobson, JW, Oppenhein, S, Sutherland, JS (1969): Plasma uric acid concentrations among Edinburgh business executives. J Am Med Assoc 208: 1141–1144.Google Scholar
2.Boyle, JA, Greig, WR, Jasani, MK, Duncan, A, Diver, M, Buchanan, WW 1967: Relative roles of genetic and environmental factors in control of serum uric acid levels in normouricemic subjects. Ann Rheum Dis 25:234–238.Google Scholar
3.Brooks, GS, Mueller, E (1966): Serum urate concentrations among university professors. J Am Med Assoc 195:415–418.CrossRefGoogle ScholarPubMed
4.Dunn, JP, Brooks, GW, Mansner, J, Rodman, GP, Cobb, S 1963: Social class gradient of serum uric acid levels in man. J Am Med Assoc 185:431–436.CrossRefGoogle Scholar
5.Fisher, RA (1918). The correlation between relatives on the supposition of Mendelian inheritance. Trans Roy Soc Edinburgh 52:399–433.CrossRefGoogle Scholar
6.French, JG, Dodge, HJ, Kjelsberg, MO 1967: A study of familial aggregation of serum uric acid levels in the population of Tecumseh, Michigan. Am J Epidemiol 86:214–224.CrossRefGoogle ScholarPubMed
7.Gulbrandsen, CL, Morton, NE, Rao, CC, Rhoads, GG, Kagan, A 1979: Determinants of plasma uric acid. Hum Genet 50:307–312.CrossRefGoogle ScholarPubMed
8.Inouye, E, Asaka, A, Park, K (1979): Genetic variation of enzyme activity. In: Studies on Normal Development and Traits Using Half-sib Method. Report of Joint Study ‘A’ Supported by the Ministry of Education, Science and Culture, 1978, p 16–21 (in Japanese).Google Scholar
9.Inouye, E (1979): Method of analysis of data. In: Studies on Normal Development and Traits Using Half-sib Method. Report of Joint Study ‘A’ Supported by the Ministry of Education, Science and Culture, 1978, p 7–13, (in Japanese).Google Scholar
10.Jensen, J, Blankenhorn, DH, Chin, HP, Sturgeon, P, Ware, AG 1965: Serum lipids and serum uric acid in human twins. J Lip Res 6:193–205.CrossRefGoogle ScholarPubMed
11.Kasl, SV, Brooks, GW, Cobb, S 1966: Serum urate concentrations in male highschool students. J Am Med Assoc 198:713–716.CrossRefGoogle Scholar
12.Montoye, HJ, Faulkner, JA, Dodge, HJ, Mikkelsen, WM, Willis, WM, Block, WD 1967: Serum uric acid concentration among business executives with observations on other coronary heart disease risk factors. Ann Int Med 66:838–850.Google Scholar
13.O'Brien, WM, Burch, TA, Bunium, JJ 1966: Genetics of hyperuricemia in Blackfeet and Pima Indians. Ann Rheum Dis 25:117–119.CrossRefGoogle ScholarPubMed
14.Orowan, E 1955: Origin of man. Nature 175:683–684.Google Scholar
15.Park, K, Inouye, E, Asaka, A 1980: Plasma and urine uric acid levels: Heritability estimates and correlation with IQ. Jpn J Hum Genet 25:193–202.CrossRefGoogle ScholarPubMed
16.Rich, RL, Nance, WE, Corey, LA, Boughman, JA (1978): Evidence for genetic factors influencing serum uric acid levels in man. In Nance, WEAllen, G, Parisi, P (eds): Twin Research: Part C. Clinical Studies. New York: Alan R. Uss, p 187–192.Google Scholar
17.Stetten, D Jr, Hearon, JZ (1959): Intellectual level measured by Army Classification Battery and serum uric acid concentration. Science 129:1737.Google Scholar