Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-20T00:15:04.233Z Has data issue: false hasContentIssue false
  • English
  • Français

Analysis of Triple Test Results in 27 Cases of Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

M. Perenc ,
L. Dudarewicz  and
B. Kałużewski
M. Perenc*
Affiliation:
Department of Medical Genetics, Institute of Endocrinology, Medical University of Łódz. Poland
L. Dudarewicz
Affiliation:
Department of Medical Genetics, Institute of Endocrinology, Medical University of Łódz. Poland
B. Kałużewski
Affiliation:
Department of Medical Genetics, Institute of Endocrinology, Medical University of Łódz. Poland
*
Department of Medical Genetics, Institute of Endocrinology, Medical University of Łódź, 91-425 Łódź, Sterling str. 3, Poland

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The study comprises 889 pregnant women between 14 and 21 weeks of gestation. The control group consisted of 862 pregant women with unburdened obstetric anamnesis with an uneventful singleton pregnancy. The examined group consisted of 27 pregnant women with uncomplicated twin pregnancy. In the sera of pregant women AFP (Microparticle Enzyme Immunoassay AxSYM Abbott), total (β-hCG (Microparticle Enzyme Immunoassay AxSYM Abbott) and unconjugated estriol (Radioimmunoassay Amerlex-M. 2T Johnson & Johnson Ortho Clinical Diagnostics Ltd.) were determined. The risk of fetal trisomy 21 was calculated with the use of PRISCA 3.0 software, which corrected the MoM values for twin pregnancy. Ulm Index was also calculated. In the majority of twin pregnancies increased concentrations of AFP, total (β-hCG and uE3 in the range over 1,0 MoM was noted. In the group of women below 35 years of age with singleton pregnancies using PRISCA 3.0 software it approximated to 95%. For women older than 35 optimum index for fetal trisomy 21 risk calculation was Ulm Index with the specificity 93,8%. The specificity of AFP determination in the detection of fetal open NTD in singleton pregnancy was 99%. In the group of women with twin pregnancy the obtained specificity of 77,8% for PRISCA 3.0 software is low, a more adavantageous way to calculate the risk of fetal trisomy 21 is Ulm Index with the specificity of 85,2%. The specificity of AFP determination as a screening for fetal open NTD in twin pregnancy was 96,3%.

Keywords

Triple testα-fetoproteinβ-hCGUnconjugated estriolTwin pregnancyFetal trisomy 21Open neural tube defect
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 47 , Issue 3-4 , October 1998 , pp. 249 - 254
Copyright
Copyright © The International Society for Twin Studies 1998

References

REFERENCES

1. Barnabei, VM, Krank, DA, Macri, JN, Larsen, JW (1995): Enhanced twin pregnancy detection within an open neural tube defect and Down syndrome screening protocol using freebeta hCG and AFP. Prenatal Diagnosis 15: 1131–1134.Google Scholar
2. Benz, R, Müller, M, Krahner-Pilat, M, Wagner-Geuder, S, Terinde, R (1993): Serum-Screening auf Down-Syndrome bei Frauen unter 35 Jahren mit einem altersunabhängigen Index. Z Geburtsh u Perinat 197: 205–208.Google Scholar
3. Cuckle, H (1995): Improved parameters for risk estimation in Down's syndrome screening. Prenatal Diagnosis 15: 1057–1065.Google Scholar
4. Goodburn, SF, Yates, JR, Raggatt, PR, Carr, C, Ferguson-Smith, ME, Kershaw, AJ, Milton, PJD, Feguson-Smith, MA (1994): Second trimester maternal serum screening using alpha-fetopro-tein, human chorionic gonadotropin, and unconjugated oestriol: experience of a regional programme. Prenatal Diagnosis 14: 391–402.CrossRefGoogle ScholarPubMed
5. Haddow, JE, Palomaki, GE, Knight, GJ, Williams, J, Pulkkinen, A, Canick, JA, Sailer, DN, Bowers, GB (1992): Prenatal screening for Down's syndrome with use of maternal serum markers. New Engl J of Med 327, 9: 588–593.Google Scholar
6. Hong, S, Berkowitz, G, Wang, W, Stone, J, Ainbender, E (1996): Unexplained elevated maternal serum alpha-fetoprotein levels and pregnancy outcome in twins. 88, 3, 337–342.Google Scholar
7. Milunsky, A (1992): Matemal serum screening for neural tube and other defects. Genetic disorders and the fetus. The Hopkins University Press, Baltimore and London 507–563.Google Scholar
8. Phillips, OP, Elias, S, Shulman, LP, Andersen, RN, Morgan, CD, Simpson, JL (1992): Maternal serum screening for fetal Down syndrome in women less than 35 years of age using alpha-feto-protein, hCG, and unconjugated estriol: a prospective 2-year study. Obstetrics & Gynaecology 80, 3, Part 1: 353–358.Google Scholar
9. Reynolds, TM (1992): Practical problems in Down syndrome screening: What should we do about gestation dating? What is the effect of assay precision on risk factors? Commun Lab Med 2: 31–38.Google Scholar
10. Wald, NJ, Cuckle, HS, Densem, JW, Kennard, A, Smith, D (1992): Maternal serum screening for Down's syndrome: the effect of routine ultrasound scan determination of gestational age and adjustment for maternal weight. Br J Obstet Gynaecol 99: 144–149.CrossRefGoogle ScholarPubMed
11. Wald, N, Cuckle, H, Hu, T et al. (1991): Maternal serum unconjugated oestriol and human gonadotropin levels in twin pregnancies: Implication for screening for Down's syndrome. Br J Obstet Gynaecol 98: 905.Google Scholar