The neonatal intensive care of twins has seen many changes over later years. In fact, major improvements in prenatal evaluation and neonatal management techniques have greatly increased the possibility of survival for infants at risk, especially those born from multiple pregnancies. Our study reports the results of a retrospective survey for the years 1990 to 1993, on the outcome of 76 twin infants (ie. 11,4% of the 661 newborns admitted to our unit over that period) correlating the clincial symptoms observed with the modality of birth.