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An Appraisal of Genetic Studies on Leprosy1

Published online by Cambridge University Press:  01 August 2014

Bernardo Beiguelman*
Affiliation:
Department of Medical Genetics, State University of Campinas, Brazil
*
Department of Medical Genetics, State University of Campinas, C.P. 1170, Campinas, SP, Brazil

Summary

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The present paper reviews the research lines which have been explored to evaluate to what extent genetic factors are intervening on the mechanism of resistance and susceptibility to leprosy.

It presents a critical discussion of the investigations on the familial association of leprosy, familial association of leprosy types, intrafamilial contagion of leprosy, concordance of leprosy in twinpairs, racial differences on leprosy prevalence and lepromatous rate, pedigree studies, association of leprosy to genetic markers, Australia antigen, and dermatoglyphic patterns. Space was also allotted to review family and twin-pair studies on the Mitsuda reaction, as well as to the investigation on the in vitro behaviour of blood macrophages against killed M. leprae.

Some areas in which further research on leprosy and genetics may be considered as prioritary are outlined with some detail.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1972

Footnotes

1

This study was supported by the World Health Organization.

References

REFERENCES

Aguas, J.T. De Las 1967. Inoculación accidental de la lepra por transfusión sanguínea en gemelos univitelinos. Fontilles, 6: 603611.Google Scholar
Alayon, F.L. 1939. Histologia do lepromin-test nos lepromarosos. Rev. Bras. Leprol., 7: 34.Google Scholar
Alayon, F.L., Souza-Lima, L. 1949. Sôbre a histologia da reação de Mitsuda em lepromatosos. Nova contribuição ao seu estudo. Rev. Bras. Leprol., 8: 367374.Google Scholar
Alonso, A.M. 1966. Lepra Dimorfa. Fundamentos de Sua Conceituação. Editora Livro S.A., Rio de Janeiro.Google Scholar
Andrade, L.M.C. 1962. Camparação entre os aspectos microscópicos e macroscópicos do teste lepromínico. Bol. Serv. Nac. Lepra, (Rio de Janeiro), 21: 95124.Google Scholar
Aycock, W.L., McKinley, E.B. 1938. The role of familial susceptibility and contagion in the epidemiology of leprosy. Int. J. Lepr., 6: 169184.Google Scholar
Aycock, W.L. 1940. Familial susceptibility as a factor in the propagation of leprosy in North America. Int. J. Lepr., 8: 137150.Google Scholar
Azulay, R.D. 1948. Estudo das intradermo-reaçães pelo 2-4 dinitroclorobenzeno e pela lepromina. An. Bras. Dermatol. Sifil., 23: 267272.Google Scholar
Azulay, R.D., Moura, A., Mourão, G. 1952. A viragem de reação lepromínica pelo BCG administrado aos doentes lepromatosos em condições clínicobacterioscópico-histopatológicas de « transferência para dispensário ». Rev. Bras. Leprol., 20: 178182.Google Scholar
Azulay, R.D. 1953. Correlações entre os diagnósticos clínico e histopatológico das várias formas de lepra. Estudo baseado em 1130 casos. Mem. VI Congr. Int. Lepr., Madrid, 12991301.Google Scholar
Azulay, R.D., Andrade, L.M.C., Silva, C., Rabello Neto, A.V., Azulay, J.D., Garrido-Neves, R., Miguez-Alonso, A. 1960. Comparison of the macroscopic readings and microscopic findings of the lepromin reaction. Int. J. Lepr., 28: 3843.Google ScholarPubMed
Barbeau, A., Trudeau, J.G., Coiteux, C. 1965. Fingerprint patterns in Huntington's Chorea and Parkinson's disease. Can. Med. Assoc. J., 92: 514516.Google ScholarPubMed
Barbieri, T.A., Correa, W.M. 1967. Human macrophage culture. The leprosy prognostic test (LPT), int. J. Lepr., 35: 377381.Google Scholar
Basombrio, G., Mom, A.M., Noussitou, F., Leon, R. 1943. Estudios sobre reactibilidad cutanea experimental en lepra. Rev. Argent. Dermatosis, 27: 406411.Google Scholar
Basombrio, G. 1956. The lepromin reaction in tuberculoid cases. Int. J. Lepr., 24: 8687.Google Scholar
Bayer, M.E., Blumberg, B.S., Werner, B. 1968. Particles associated with Australia antigen in the sera of patients with leukemia, Down's syndrome and hepatitis. Nature (Lond.), 218: 10571059.Google Scholar
Bechelli, L.M., Quagliato, R. 1953. Teste de Mitsuda na lepra tuberculóide em reação. Rev. Bras. Leprol., 21: 5158.Google Scholar
Bechelli, L.M., De Souza, P.R., Quagliato, R. 1959. Correlação entre os resultados da leitura clínica e do exame histopatológico da reação de Mitsuda. Rev. Bras. Leprol., 27: 172182.Google Scholar
Bechelli, L.M., Garcia, G., Nakamura, S., Quagliato, R. 1963. Determinação da data da leitura da reação de Mitsuda com lepromina integral em individuos sãos, sem exposição prévia conhecida ao M. leprae . An. VIII Congr. Int. Lepr., Rio de Janeiro, 3: 284294.Google Scholar
Bechelli, L.M., Martinez-Dominguez, V., Patwary, K.M. 1966. WHO epidemiologic random sample surveys of leprosy in Northern Nigeria (Katsina), Cameroon and Thailand (Khon Kaen). Int. J. Lepr., 34: 223243.Google Scholar
Bechelli, L.M., Garbajosa, G., Uemura, K., Engler, V., Martinez-Dominguez, V., Paredes, L., Sundaresan, T., Koch, G., Matejka, M. 1970. BCG vaccination of children against leprosy. Preliminary findings of the WHO — controlled trial in Burma. Bull. WHO, 42: 235281.Google ScholarPubMed
Bechelli, L.M., Guinto, R.S. 1970. Some recent laboratory findings on Mycobacterium leprae . Bull. WHO, 43: 559569.Google ScholarPubMed
Beiguelman, B. 1962 a. Reação gustativa à feniltiocarbamida e lepra. Rev. Bras. Leprol., 30: 111124.Google Scholar
Beiguelman, B. 1962 b. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30: 153172.Google Scholar
Beiguelman, B. 1963. Grupos sanguíneos e lepra. Rev. Bras. Leprol., 31: 3444.Google Scholar
Beiguelman, B., Marques, M.B. 1964. Taste sensitivity to phenylthiourea and drugs with antileprotic effect. Acta Genet. Med. Gemellol., 13: 200202.Google Scholar
Beiguelman, B. 1964 a. Taste sensitivity to phenylthiourea among patients affected with both tuberculosis and leprosy. Acta Genet. Med. Gemellol., 13: 190192.Google Scholar
Beiguelman, B. 1964 b. Taste sensitivity to phenylthiourea and leprosy. Acta Genet. Med. Gemellol., 13: 193196.Google Scholar
Beiguelman, B. 1964 c. Sistema ABO e epidemiologia de lepra. Rev. Paul. Med., 65: 8086.Google Scholar
Beiguelman, B. 1965. The genetics of resistance to leprosy. Int. J. Lepr., 33: 808812.Google Scholar
Beiguelman, B., Quagliato, R. 1965. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33: 800807.Google ScholarPubMed
Beiguelman, B., Barbieri, T.A. 1965. Comportamento dos macrófagos nas formas polares de lepra. Ciência e Cultura, 17: 304305 Google Scholar
Beiguelman, B., Quagliato, R., Camargo, D.P. 1965. Influence of repeated lepromin injections on the Mitsuda skin reaction. Int. J. Lepr., 33: 795799.Google Scholar
Beiguelman, B., Pinto, W. Jr., Dall'Aglio, F.F., Da Silva, E., Vozza, J.A. 1966. Deficiência de desidrogenase de 6-fosfato de glicose (G-6PD) e lepra. Ciência e Cultura, 18: 9596.Google Scholar
Beiguelman, B. 1967. Leprosy and Genetics. A review of past research with remarks concerning future investigations. Bull. WHO, 37: 461476.Google Scholar
Beiguelman, B., Souza-Campos, N., Pinto, W. Jr. 1967. Fatôres genéticos e efeito da calmetização na reação de Mitsuda. Rev. Paul. Med., 71: 271278.Google Scholar
Beiguelman, B. 1968 a. Dinâmica dos Genes nas Populaçães e nas Familias. EDART, São Paulo.Google Scholar
Beiguelman, B. 1968 b. Some remarks on the problem of the genetics of leprosy resistance. Acta Genet. Med. Gemellol., 17: 584594.Google Scholar
Beiguelman, B., Dall'Aglio, F.F., Da Silva, E. 1968 a. Análise da recorrência familial de lepra. Rev. Paul. Med., 72: 105110.Google Scholar
Beiguelman, B., Dall'Aglio, F.F., Da Silva, E. 1968 b. Estudo das formas polares de lepra pela análise de pares de irmãos. Rev. Paul. Med., 72: 111119.Google Scholar
Beiguelman, B., Da Silva, E., Dall'Aglio, F.F. 1968 c. Lepra e sexo. Rev. Paul. Med., 72: 120129.Google Scholar
Beiguelman, B., Pinto, W. Jr., Dall'Aglio, F.F., Da Silva, E., Vozza, J.A. 1968 d. G-6PD deficiency among lepers and healthy people in Brazil. Acta Genet. (Basel), 18: 159162.Google Scholar
Beiguelman, B. 1971. Lepromin reaction. Genetic studies including twin pair analysis. Acta Lepr. (Genève), 44: 565.Google Scholar
Benewolenskaja, S.W. 1932. Ueber die in-vitroreaktion der embryonalen Gewebe und Leukozyten des Menschen auf Leprabazillen. Arch. Exp. Zellforsch., 13: 3746.Google Scholar
Blumberg, B.S. 1964. Polymorphisms of serum proteins and the development of isoprecipitins in transfused patients. Bull. N.Y. Acad. Med., 40: 377386.Google Scholar
Blumberg, B.S., Alter, H.J. 1965. Precipitating antibodies against a serum protein (“Australia antigen”) in the serum of transfused hemophilia patients. J. Clin. Invest., 44: 1029.Google Scholar
Blumberg, B.S., Alter, H.J., Visnich, S. 1965. A “new” antigen in leukemia sera. J.A.M.A., 191: 541546.Google Scholar
Blumberg, B.S. 1966. An inherited serum isoantigen in leukemia and Down's syndrome. J. Clin. Invest., 45: 988.Google Scholar
Blumberg, B.S., Melartin, L. 1966. Conjectures on inherited susceptibility to lepromatous leprosy. Int. J. Lepr., 34: 6064.Google Scholar
Blumberg, B.S., Melartin, L., Guinto, R.A., Werner, B. 1966. Family studies of human serum isoantigen system (Australia antigen). Am. J. Hum. Genet., 18: 594608.Google Scholar
Blumberg, B.S., Gerstley, B.J.S., Hungerford, D.A., London, W.T., Sutnick, A.I. 1967. A serum antigen (Australia antigen) in Down's syndrome, leukemia and hepatitis. Ann. Intern. Med., 66: 924931.Google Scholar
Blumberg, B.S., Friedlander, J.S., Woodside, A., Sutnick, A.I., London, W.T. 1969. Hepatitis and Australia antigen: autosomal recessive inheritance of susceptibility to infection in humans. Proc. Natl. Acad. Sci. U.S.A., 62: 11081115.Google Scholar
Blumberg, B.S., Melartin, L., Guinto, R., Lechat, M. 1970. Lepromatous leprosy and Australia antigen with comments on the genetics of leprosy. J. Chronic. Dis., 23: 507516.Google Scholar
Breibart, S., Mellman, W.J., Eberlein, W.R. 1964. Developmental retardation associated with an unbalanced 13-15/18 translocation. Cytogenetics, 3: 252257.Google Scholar
Bullock, W.E. 1968. Studies of immune mechanisms in leprosy. I-Depression of delayed allergic responses to skin test antigens. N. Engl. J. Med., 278: 298304.Google Scholar
Büngeler, W., Fernandez, J.M.M. 1940. Estudo clínico e histopatológico das reaçães alérgicas na lepra. Ia. Parte: Investigaçães clínicas sôbre a reação à lepromina (reação de Mitsuda). Rev. Bras. Leprol., 8: 157170.Google Scholar
Clarke, C., Stevenson, A.C., Davies, P., Williams, C.E. 1964. A family apparently showing transmission of a translocation between chromosome 3 and one of the “X-6-12” or “C” group. Appendix of S.B. Holt. J. Med. Genet., 1: 2734.Google Scholar
Cochrane, R.G. 1947. Practical Textbook of Leprosy. Oxford.Google Scholar
Contreras, F., Guillén, J., Tabarin, J., Terencio, J. 1958. Resultados clínicos e inmunobiológicos en hansenianos adultos vacunados con BCG por via oral. Fontilles, 4: 3338.Google Scholar
Convit, J., Gonzales, C.L., Rassi, E. 1952 a. Estudios sobre lepra en el grupo étnico aleman de la Colonia Tovar, Venezuela. Int. J. Lepr., 20: 185193.Google Scholar
Convit, J., Rassi, E., Rodriguez, F.C., Contreras, R. 1952 b. Changes in the lepromin and tuberculin reactions of lepromin negative leprosy patients after vaccination with BCG. Int. J. Lepr., 20: 347354.Google Scholar
Convit, J., Rassi, E. 1954. Lepromin and tuberculin tests in Venezuelan leprosy foci. Induction of lepromin reactivity by BCG vaccination. Int. J. Lepr., 23: 303310.Google Scholar
Coudert, J., Basset, A., Rousset, J., Pradinaud, R., Lu-Huynh-Than, H. 1965. A propos de la valeur immunologique de la réaction de Mitsuda. Bull. Soc. Pathol. Exot., 58: 132140.Google Scholar
Danielssen, D.C., Boeck, W. 1848. Traité de la Spédalskhead ou Éléphantiasis des Grecs. French translation by Cosson, L.A., Baillère, Paris.Google Scholar
De Faria, J.L. 1953. Contribuição ao Conhecimento da Natureza da Reação de Mitsuda. Depto. Imp. Nac., Rio de Janeiro.Google Scholar
De Grouchy, J. 1965. Chromosome 18: a topological approach. J. Pediatr., 66: 414431.Google Scholar
Del Favero, W. 1948. O censo intensivo de Candeias. Arq. Serv. Nac. Lepra (Rio de Janeiro), 6: 87235.Google Scholar
Dharmendra, , Chatterjee, K.R. 1955. Prognostic value of the lepromin test in contacts of leprosy cases. Leprosy in India, 27:149152.Google Scholar
Doull, J.A., Guinto, R.S., Rodriguez, J.N., Bancroft, H. 1942. The incidence of leprosy in Cordova and Talisay, Cebu, P.I. Int. J. Lepr., 10: 107131.Google Scholar
Doull, J.A., Guinto, R.S., Mabalay, M.C. 1957. Effect of BCG vaccination, lepromin testing and natural causes in inducing reactivity to lepromin and to tuberculin. Int. J. Lepr., 25: 1337.Google Scholar
Engel, E., Forbes, A.P. 1965. Cytogenetic and clinical findings in 48 patients with congenitally defective or absent ovaries. Medicine (Baltimore), 44: 135164.Google Scholar
Enna, C.D., Elliott, J.P., Stockwell, F.E. 1970. An evaluation of dermatoglyphics in leprosy. A pilot study. Int. J. Lepr., 38: 177186.Google ScholarPubMed
Farquhar, H.G., Walker, S. 1964. An XXXXY chromosome abnormality. Ann. Hum. Genet., 28: 1119.Google Scholar
Floch, H. 1952. Réaction de Mitsuda et intradermoréaction au BCG tué dans la lèpre. Conclusions théoriques et practiques. Ann. Inst. Pasteur (Paris), 82: 517527.Google Scholar
Fonte, J. 1967. Epidemiologia e profilaxia da lepra. Bol. Serv. Nac. Lepra (Rio de Janeiro), 26: 3146.Google Scholar
Forbes, A.P. 1964. Finger prints and palm prints (dermatoglyphics) and palmar-flexion creases in gonadal dysgenesis, pseudohypoparathyroidism and Klinefelter's syndrome. N. Engl. J. Med., 270: 12681277.Google Scholar
Gibson, D.A., Uchida, I.A., Lewis, A.J. 1963. A review of the 18 trisomy syndrome. Med. Biol. Illus., 13: 8088.Google Scholar
Giles, J.P., McCollum, R.W., Berndtson, L.W., Krugman, S. 1969. Viral hepatitis. Relation of Australia/SH antigen to the Willowbrook MS2 strain. N. Engl. J. Med., 281: 119122.Google Scholar
Godal, T., Rees, R.J.W. 1970. Fate of Mycobacterium leprae in macrophages of patients with lepromatous and tuberculoid leprosy. Int. J. Lepr., 38: 439442.Google Scholar
Guinto, R.S., Doull, J.A., Mabalay, E.B. 1955. A note on the lepromin reaction in males and females of the general population of Cordova, Mactan Island, Cebu, Philippines. Int. J. Lepr., 23: 131134.Google Scholar
Guinto, R.S., Malabay, M.C., Doull, J.A. 1962. Cutaneous responses to lepromin and other mycobacterial antigens. Int. J. Lepr., 30: 152165.Google Scholar
Gupta, M.C., Gupta, S.R. 1966. Blood groups in relation to pulmonary tuberculosis and leprosy. Indian J. Med. Sci., 20: 353356.Google Scholar
Hanks, J.H. 1947 a. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr., 15: 2130.Google Scholar
Hanks, J.H. 1947 a. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J. Lepr., 15: 3147.Google Scholar
Hanks, J.H. 1947 c. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15: 4864.Google Scholar
Hanks, J.H., Chatterjee, B.R., Lechat, M.F. 1964. A guide to the counting of mycobacteria in clinical and experimental materials. Int. J. Lepr., 32: 156167.Google Scholar
Hanks, J.H. 1968 a. Precautions for injecting uniform doses of lepromin. Int. J. Lepr., 36: 6465.Google Scholar
Hanks, J. H. 1968 b, Standardizable lepromins yielding uniform concentration of M. leprae per skin site. Int. J. Lepr., 36: 6675.Google Scholar
Hanks, J.H. 1968 c. Microscopic counts of mycobacteria conversion factors for the pinhead method. Int. J. Lepr., 36: 7677.Google Scholar
Hanks, J.H., Abe, M., Nakayama, T., Tuma, M., Bechelli, L.M., Martinez-Dominguez, V. 1970. Studies towards the standardization of lepromin. Bull. WHO, 42: 703709.Google Scholar
Hausfeld, R.G. 1970. An anthropological method for measuring exposure to leprosy in a leprosyendemic population at Karimui, New Guinea. Bull. WHO, 43: 863877.Google Scholar
Hayashi, F. 1933. Mitsuda's skin reaction in leprosy. Int. J. Lepr., 1: 3138.Google Scholar
Hirschman, R.J., Schulman, N.R., Barker, L.F., Smith, K.O. 1969. Virus-like particles in sera of patients with infectious and serum hepatitis. J.A.M.A., 208: 16671670.Google Scholar
Hodges, R.E., Simon, J.R. 1962. Relationship between fingerprint patterns and Wilson's disease. J. Lab. Clin. Med., 60: 629640.Google Scholar
Holt, S.B., Lindsten, J. 1964. Dermatoglyphic anomalies in Turner's syndrome. Ann. Hum. Genet., 28: 87100.Google Scholar
Horton, R.J., Povey, S. 1966. Family studies in leprosy. Int. J. Lepr., 34: 408410.Google Scholar
Hsuen, J., Thomas, E., Jesudian, G. 1963. ABO blood groups and leprosy. Lepr. Rev., 34: 143147.Google Scholar
Ignácio, J.L., Palafox, C.A., José, F.A. Jr. 1955. Mitsuda reactions induced by repeated lepromin testing in children removed at birth from their leprous parents. Failure of BCG to induce strong reactivity in persistently moderate reactors. Int. J. Lepr., 23: 259269.Google Scholar
Jacobsen, T.S., Tischler, B., Miller, J.R. 1964. Enlarged chromosomal satellites associated with mental retardation and digital arches in three generations. Ann. Hum. Genet., 28: 2126.Google Scholar
Jonquieres, E.D.L., Masanti, J.G. 1954. Vacunación con BCG y viraje de la leprominorreación en enfermos de lepra. Rev. Argent. Dermatosif., 38: 137144.Google Scholar
Kapoor, P. 1963. Epidemiological survey of leprosy in Mahrashtra (India). Leprosy in India, 35: 8389.Google Scholar
Keil, E. 1939. Hereditary factors in leprosy. Lepr. Rev., 10: 163171.Google Scholar
Kinnear-Brown, J.A., Stone, M.M. 1958. Tuberculoid leprosy in identical twins. Lepr. Rev., 29: 5355.Google Scholar
Lechat, M.F., Bile, T., Rassi, E. 1967. A study of blood groups and leprosy in the population of Colonia Tovar, Venezuela. Int. J. Lepr., 35: 488493.Google Scholar
Lechat, M.F., Bias, W.B., Guinto, R.S., Cohen, B.H., Tolentino, J.G., Abalos, R.M. 1968 a. A study of various blood group systems in leprosy patients and controls in Cebu, Philippines. Int. J. Lepr., 36: 1731.Google Scholar
Lechat, M.F., Bias, W.B., Blumberg, B.S., Melartin, L., Guinto, R.S., Cohen, B., Tolentino, J.G., Abalos, R.M. 1968 b. A controlled study of polymorphisms in serum globulin and glucose-6-phosphate-dehydrogenase deficiency in leprosy. Int. J. Lepr., 36: 179191.Google Scholar
Lechat, M.F. 1969. L'étude du polymorphisme génétique dans la lèpre, perspectives d'avenir et difficultés. Acta Lepr. (Genève), 34/35: 110114.Google Scholar
Lee, C.S.N., Bowen, P., Rosenblum, H., Linsao, L. 1964. Familial chromosome 2-3 translocation ascertained through an infant with multiple malformations. N. Engl. J. Med., 271: 1216.Google Scholar
Leiker, D.L. 1966. Classification of Leprosy. Lepr. Rev., 37: 715.Google Scholar
Lele, K.P., Penrose, L.S., Stallard, H.B. 1963. Chromosome deletion in a case of retinoblastoma. Ann. Hum. Genet., 27: 171174.Google Scholar
Lie, G.W., Coenegracht, J.M., Stalder, G. 1964. A very large metacentric chromosome in a woman with symptoms of Turner's syndrome. Cytogenetics (Basel), 3: 427440.Google Scholar
London, W.T., Sutnick, A.I., Blumberg, B.S. 1969 a. Australia antigen and acute viral hepatitis. Ann. Intern. Med., 70: 5559.Google Scholar
London, W.T., Difiglia, M., Sutnick, A.I., Blumberg, B.S. 1969 b. An epidemic of hepatitis in a chronic hemodialysis unit. Australia antigen and difference in host response. N. Engl. J. Med., 281: 571578.Google Scholar
Lowe, J., McNulty, F. 1953. Tuberculosis and leprosy. Immunological studies. Lepr. Rev., 34: 6190.Google Scholar
Mariani, G. 1924. Osservazioni sopra una forma speciale di allergia cutanea nella lebbra (Lepra tuberculoide sperimentale nell'uomo). Pathologica, 16: 471477.Google Scholar
Mariani, G. 1925. Nuove osservazioni nelle reazioni provocate sperimentalmente con materiale lebbroso nell'uomo. G. Ital. Dermatol., 66: 402426.Google Scholar
Martinez-Dominguez, V. 1953. Estudio epidemiológico y clínico de la endemia de lepra en la Guinea Española. Mem. VI Cong. Int. Lepr., Madrid, 11041204.Google Scholar
Millman, I., Zavatone, V., Gerstley, B.J.S., Blumberg, B.S. 1969. Australia antigen in the nuclei of liver cells of patients with viral hepatitis detected by the fluorescent antibody technique. Nature (London), 222: 181184.Google Scholar
Mitsuda, K. 1924. Les lépreux maculo-nerveux, d'une part, les tubéreux, d'autre part, se comportent différement a la suite d'une inoculation d'émulsion de tubercule lépreux. IIIe. Conf. Internat. Lèpre (Strasbourg, 1923), J.B. Baillère et Fils, Paris, 219220.Google Scholar
Mohamed-Ali, P. 1965 a. A study of conjugal leprosy. Int. J. Lepr., 33: 223228.Google Scholar
Mohamed-Ali, P. 1965 b. Genetic influence in leprosy. Leprosy in India, 37: 252267.Google Scholar
Mohamed-Ali, P., Ramanujam, K. 1966. Leprosy in twins. Int. J. Lepr., 34: 405407.Google Scholar
Mom, A.M., Basombrio, G. 1944. Estudio comparative entre la leprominorreacción y la intradermorreaccion por el 2-4 dinitroclorobenceno en enfermos de lepra, convivientes y controles sanos. Rev. Argent. Dermatosis, 28: 165169.Google Scholar
Mom, A.M., Basombrio, G. 1945. Estudios de reactibilidad cutánea en lepra. Las intradermorreacciones provocadas por la lepromina y el 2-4 dinitroclorobenceno. Rev. Argent. Dermatosis, 29: 120128.Google Scholar
Nagai, K. 1938. Histopathologische Befunde nach Anstellung der Mitsuda' sehen Reaktion. La Lepro, 9: 26.Google Scholar
Nolasco, J.O. 1940. The lepromin test in lepra reaction. II-Histology of the reaction lesions and persistence of the injected bacilli. Int. J. Lepr., 8: 285296.Google Scholar
Nordeen, S.K., Mohamed-Ali, P. 1964. A study of 579 families having multiple cases of leprosy. Leprosy in India, 36: 176181.Google Scholar
Okochi, K., Murakami, S. 1968. Observations on Australia antigen in Japanese. Vox Sang., 15: 374385.Google Scholar
Olmos-Castro, N., Arcuri, P.B. 1957. Lepromin hypersensitivity induced by integral lepromin in persons presumably free from leprosy. Int. J. Lepr., 25: 375379.Google ScholarPubMed
Páteo, D. Do, Pereira, N.S. 1936. Da frequência de lepra nos focos familiares. Estudo epidemiológico. Rev. Bras. Leprol., 4: 241259.Google Scholar
Paula-Souza, R., Ferraz, N.T., Bechelli, L.M. 1953. Influência do BCG vivo e morto sôbre a reação de Mitsuda. (Observações preliminares). Rev. Bras. Leprol., 21: 4350.Google Scholar
Paula-Souza, R., Bechelli, L.M. 1960. Correlação entre as reaçães lepromínica e tuberculínica em crianças de o a 4 anos. Rev. Bras. Leprol., 28: 203210.Google Scholar
Pettit, J.H.S., Chin, J. 1964. Does glucose-6-phosphate-dehydrogenase deficiency modify the course of leprosy or its treatment? Lepr. Rev., 35: 149156.Google Scholar
Pfaltzgraff, R.E. 1966. The classification of leprosy. Lepr. Rev., 38: 1523.Google Scholar
Pinsky, L., George, A.M. 1965. A familial syndrome of facial and skeletal anomalies associated with genital abnormality in the male and normal genitals in the female. J. Pediat., 66: 10491054.CrossRefGoogle Scholar
Pisani, R.C.B., Beiguelman, B., Opromolla, D.W.A., In vitro behaviour of blood derived macrophages against killed Mycobacterium leprae. (To be published).Google Scholar
Porrit, R.J., Olsen, R.E. 1947. Two simultaneous cases of leprosy developing in tatoos. Am. J. Pathol., 23: 805817.Google Scholar
Povey, M.S., Horton, R.J. 1966. Leprosy and blood groups. Lepr. Rev., 37: 147150.Google Scholar
Prasad, K.V.N., Mohamed-Ali, P. 1966 a. ABO blood groups and leprosy. Int. J. Lepr., 34: 398404.Google Scholar
Prasad, K.V.N., Mohamed-Ali, P. 1966 b. Some genetic aspects in the epidemiology of leprosy. Lepr. Rev., 38: 4956.Google Scholar
Prince, A.M. 1968. Relation of Australia and SH antigens. Lancet, 2: 462463.Google Scholar
Quagliato, R., Bechelli, L.M. 1953. Tentativa de viragem da reação leprominica pelo BCG em doentes de lepra. Int. J. Lepr., 21: 591592.Google Scholar
Quagliato, R. 1957 a. Lepra conjugal. Rev. Bras. Leprol., 25: 5968.Google Scholar
Quagliato, R. 1957 b. Resultados colhidos pela vacinação com o BCG e meios de sua avaliação. Rev. Bras. Leprol., 25: 368389.Google Scholar
Quagliato, R. 1959. Classificação de lepra-Madrid, 1953. Critério clínico. Confronto com os resultados da bacterioscopia, imunologia e histologia — 250 casos do Dispensário de Campinas (1949-1958). Rev. Bras. Leprol., 27: 1732.Google Scholar
Quagliato, R. 1962. Interpretação das reações limítrofes ou duvidosas do teste lepromínico. Bol. Serv. Nac. Lepra (Rio de Janeiro), 21: 1334.Google Scholar
Rao, P.S.S., Karat, A.B.A., Karat, S. 1969. Epidemiological studies in leprosy in Gudiyatham Taluk. II. Patterns of familial aggregation of leprosy in an endemic area. Lepr. Rev., 40: 9398.Google Scholar
Ribeiro, L. 1934. A lepra é capaz de destruir as impressões digitais. Bol. Acad. Nac. Med. (Rio de Janeiro), 106: 204209.Google Scholar
Ribeiro, L. 1935. La lèpre est capable d'altérer les dessins papillaires des empreintes digitales. Int. J. Lepr., 3: 195196.Google Scholar
Ribeiro, L. 1936. A prioridade das pesquisas sôbre as impressões digitais. Brasil-Médico, 5: 438440.Google Scholar
Ridley, D.S., Jopling, W.H. 1962. A classification of leprosy for research purposes. Lepr. Rev., 33: 119128.Google Scholar
Ridley, D.S., Jopiing, W.H. 1966. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr., 34: 255273.Google Scholar
Ridley, D.S. 1969. Reactions in leprosy. Lepr. Rev., 40: 7781.Google Scholar
Rodriguez, R.P. 1950. Reacción de Mitsuda: estudio histopatológico. Bol. Soc. Cubana Dermatol. Sifil., 7: 116.Google Scholar
Rosemberg, J., Souza-Campos, N., Aun, J.N., Passos Filho, M.C.R. 1960. Immunobiologic relations between tuberculosis and leprosy. X. Comparative study of the results of the lepromin test in subjects submitted to serial injections of Mitsuda's antigen and to oral BCG vaccination. Int. J. Lepr., 28: 271283.Google Scholar
Rotberg, A. 1937. Some aspects of immunity on leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromin tested cases. Rev. Bras. Leprol., 5: 4597.Google Scholar
Saengudom, C., Flatz, G. 1967. Zur Verbreitung der ABO-Blutgruppen in der Bevölkerung Northailands. Humangenetik, 3: 319327.Google Scholar
Saldanha, P.H. 1960. Frequencies of consanguineous marriages in Northeast of São Paulo, Brazil. Acta Genet. (Basel), 10: 7188.Google Scholar
Salzano, F.M., Hirschfeld, J. 1965. The dynamics of the Gc polymorphism in a Brazilian population. Acta Genet. (Basel), 17: 116125.Google Scholar
Salzano, F.M. 1967. Blood groups and leprosy. J. Med. Genet., 4: 102106.Google Scholar
Salzano, F.M., Suñé, M., Ferlauto, M. 1967. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17: 530544.Google Scholar
Salzano, F.M., Blumberg, B.S. 1970. The Australia antigen in Brazilian healthy persons and in leprosy and leukaemia patients. J. Clin. Pathol., 23: 3942.Google Scholar
Sánchez-Cascos, A. 1964. Finger print patterns in congenital heart disease. Br. Heart J., 26: 524527.Google Scholar
Saúl, A., Díaz, M. 1965. Lepra y herencia. Dermatologia (Mexico), 9: 157169.Google Scholar
Schujman, S. 1936. Histopatologia de la reacción de Mitsuda. Estudio progresivo y comparativo de las reacciones que provoca en las diversas formas de lepra. Rev. Bras. Leprol., 4: 469475.Google Scholar
Schujman, S. 1956. Subsequent evolution of the induced Mitsuda reaction in clinically and bacteriologically negative lepromatous cases. Int. J. Lepr., 24: 5156.Google Scholar
Schwantes, A.R., Salzano, F.M., De Castro, I.V., Tondo, C.V. 1967. Haptoglobins and leprosy. Acta Genet. (Basel), 17: 127136.Google Scholar
Sehgal, V.N., Mathur, J.S., Rao, N.S.N. 1966. ABO blood groups in leprosy. Lepr. Rev., 37: 221224.Google Scholar
Sehgal, V.N., Dube, B. 1967. Secretion of blood group specific substances in the saliva of leprosy patients. Int. J. Lepr., 35: 375376.Google ScholarPubMed
Silva, C.O., Rabello-Neto, A.V., Castro, I. 1955. Ação do BCG sôbre a lepromino-reação em comunicantes de casos de lepra. Bol. Serv. Nac. Lepra (Rio de Janeiro), 14: 124135.Google Scholar
Singh, G., Ohja, D. 1967. Leprosy and ABO blood groups. J. Med. Genet., 4: 107108.Google Scholar
Souza-Campos, N. 1953. O BCG na profilaxia da lepra (revisão bibliográfica). Rev. Bras. Leprol., 21: 292314.Google Scholar
Souza-Campos, N., Leser, W., Quagliato, R., Bechelli, L.M., Rotberg, A. 1962. Viragem da leprominoreação em função de diferentes estímulos. Influência da idade, nessa viragem, no grupo etário de 6 a 34 meses. Rev. Bras. Leprol., 29: 320.Google Scholar
Souza-Lima, L., Cerqueira, G.C. 1946. Tratamento experimental da lepra pelas diamino-difenilsulfonas. II Conf. Panamer. Lepra. Arq. Serv. Nac. Lepra (Rio de Janeiro), 4: 976.Google Scholar
Souza-Lima, L., De Souza, P.R. 1949. Pseudoexacerbation of leprosy due to the diaminodiphenylsulfones. Int. J. Lepr., 17: 1921.Google Scholar
Souza-Lima, L., Souza-Campos, N. 1950. Sôbre Casos de Lepra com Evolução Anômala. Serv. Nac. Lepra, Rio de Janeiro.Google Scholar
Souza-Lima, L. 1953. Estado Atual da Terapêutica da Lepra. Serv. Nac. Lepra, São Paulo, Brasil.Google Scholar
Spickett, S.G. 1962 a. Genetics and the epidemiology of leprosy. I. The incidence of leprosy. Lepr. Rev., 33: 7693.Google Scholar
Spickett, S.G. 1962 b. Genetics and the epidemiology of leprosy. II. The form of leprosy. Lepr. Rev., 33: 173181.Google Scholar
Steiniger, F. 1941. Die erbliche Disposition bei der Entstehung der Lepra. Z. Menschl. Vererbungsu. Konstitutionslehre, 25: 245272.Google Scholar
Sutnich, A.I., London, W.T., Gerstley, B.J.S., Cronlund, M.M., Blumberg, B.S. 1968. Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down's syndrome. J.A.M.A., 205: 670674.Google Scholar
Tolentino, J.G. 1938. The role of heredity in the transmission of leprosy. Monthly Bull. Bureau Health (Manila), 18: 261272.Google Scholar
Townes, P.L., Ziegler, N.A. 1965. D/E (13-15/17-18) translocation. Am. J. Dis. Child., 110: 686688.Google Scholar
Treo, M.M., Silva, C.O. 1963. Comportamento do Mycobacterium leprae in vitro em sangue total ou plasma de leprosos de diferentes formas clínicas. An. VIII Cong. Internac. Leprol. (Rio de Janeiro), 3: 484494.Google Scholar
Turk, J.L., Waters, M.F.R. 1969. Cell-mediated immunity m patients with leprosy. Lancet 2: 243246.Google Scholar
Uchida, I.A., Miller, J.R., Soltan, H.C. 1964 a. Dermatoglyphics associated with XXYY chromosome complement. Am. J. Hum. Genet., 16: 284291.Google Scholar
Uchida, I.A., Wong, H.C., Laxdal, O.E., Zaleski, W.A., Duncan, B.P. 1964 b. Partial trisomy-deficiency syndrome resulting from a reciprocal translocation in a large kindred. Cytogenetics (Basel), 3: 8196.Google Scholar
Verma, B.S., Dongre, A.V. 1965. Leprosy and ABO blood groups. Lepr. Rev., 36: 211213.Google Scholar
Vogel, F., Chakravartti, M.R. 1966. ABO blood groups and the type of leprosy in an Indian population. Humangenetik, 3: 186188.Google Scholar
Vogel, F. 1968. ABO blood groups and leprosy. J. Med. Genet., 5: 5657.Google Scholar
Vogel, F., Krüger, J., Song, Y.K., Flatz, G. 1969. ABO blood groups, leprosy and serum proteins. Humangenetik, 7: 149162.Google Scholar
Vogel, F., Krüger, J., Chakravartti, M.R., Ritter, H., Flatz, G. 1971. ABO blood groups, Inv serum groups and serum proteins in leprosy patients from West Bengal (India). Humangenetik, 12: 284301.Google Scholar
Yanagisawa, K., Asami, N., Maeda, M., Ishihara, S., Goto, S., Kobayashi, S., Tachikawa, N. 1960. Comparative studies of intradermal reaction provoked by Dharmendra antigen and the antigens of various acid fast bacilli. La Lepra, 29: 226231.Google Scholar
Yankah, J.A.K. 1965. Observations on the frequency of ABO and Rh blood groups in leprosy and non-leprosy people in Ghana. Lepr. Rev., 36: 7374.Google Scholar
Yokota, T. 1953. The histopathological study of Mitsuda reaction in the case of lepromatous leprosy. La Lepra, 22: 232235.Google Scholar