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Candidate Genes and Political Behavior

Published online by Cambridge University Press:  13 February 2012

EVAN CHARNEY  and
WILLIAM ENGLISH
EVAN CHARNEY*
Affiliation:
Duke University
WILLIAM ENGLISH*
Affiliation:
Harvard University
*
Evan Charney is Associate Professor of the Practice of Public Policy and Political Science, Sanford School of Public Policy, Duke University, 250 Rubenstein Hall, 302 Towerview Drive, Duke Box 90311, Durham, NC 27708 ([email protected]).
William English is Lab Fellow, Edmond J. Safra Center for Ethics, Harvard University, 124 Mount Auburn Street, Cambridge, MA 02138 ([email protected]).
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Abstract

Political scientists are making increasing use of the methodologies of behavior genetics in an attempt to uncover whether or not political behavior is heritable, as well as the specific genotypes that might act as predisposing factors for—or predictors of—political “phenotypes.” Noteworthy among the latter are a series of candidate gene association studies in which researchers claim to have discovered one or two common genetic variants that predict such behaviors as voting and political orientation. We critically examine the candidate gene association study methodology by considering, as a representative example, the recent study by Fowler and Dawes according to which “two genes predict voter turnout.” In addition to demonstrating, on the basis of the data set employed by Fowler and Dawes, that two genes do not predict voter turnout, we consider a number of difficulties, both methodological and genetic, that beset the use of gene association studies, both candidate and genome-wide, in the social and behavioral sciences.

Type
Research Article
Information
American Political Science Review , Volume 106 , Issue 1 , February 2012 , pp. 1 - 34
Copyright
Copyright © American Political Science Association 2012

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References

REFERENCES

Alford, John R., Funk, Carolyn L., and Hibbing, John R.. 2005. “Are Political Orientations Genetically Transmitted?” American Political Science Review 99 (2): 153–67.CrossRefGoogle Scholar
Alia-Klein, Nelly, Kriplani, Aarti, Pradhan, Kith, Yeming Ma, Jim, Logan, Jean, Williams, Benjamin, Craig, Ian W. et al. 2008. “The MAO-A Genotype Does Not Modulate Resting Brain Metabolism in Adults.” Psychiatry Research: Neuroimaging 164 (1): 73–76.CrossRefGoogle ScholarPubMed
Alkan, Can, Coe, Bradley P., and Eichler, Evan E.. 2011. “Genome Structural Variation Discovery and Genotyping.” Nature Reviews Genetics 12 (5): 363–76.CrossRefGoogle ScholarPubMed
Ansolabehere, Stephen, and Hersh, Eitan. 2008. “Vote Validation in the 2006 CCES.” Harvard University. Unpublished manuscript.Google Scholar
Balciuniene, Jorune, Syvänen, Anne-Christine, McLeod, Howard L., Pettersson, Ulf, and Jazin, Elena E.. 2001. “The Geographic Distribution of Monoamine Oxidase Haplotypes Supports a Bottleneck during the Dispersion of Modern Humans from Africa.” Journal of Molecular Evolution 52 (2): 157–63.CrossRefGoogle ScholarPubMed
Beaver, K. M., and Belsky, J.. N.d. “Gene-Environment Interaction and the Intergenerational Transmission of Parenting: Testing the Differential-Susceptibility Hypothesis.” Psychiatric Quarterly. Forthcoming.Google Scholar
Beaver, K. M., Mancini, C., DeLisi, M., and Vaughn, M.G.. 2011. “Resiliency to Victimization: The Role of Genetic Factors.” Journal of Interpersonal Violence 26 (5): 874–98.CrossRefGoogle ScholarPubMed
Beaver, K. M., Delisi, M., Vaughn, M.G., and Wright, J.P.. 2010. “Association between the A1 Allele of the DRD2 Gene and Reduced Verbal Abilities in Adolescence and Early Adulthood.” Journal of Neural Transmission 117 (7): 827–30.CrossRefGoogle ScholarPubMed
Beaver, K. M., Wright, J.P., DeLisi, M., Daigle, L.E., Swatt, M.L., and Gibson, C.L.. 2007a. “Evidence of a Gene × Environment Interaction in the Creation of Victimization.” International Journal of Offender Therapy and Comparative Criminology 51 (6): 620–45.CrossRefGoogle ScholarPubMed
Beaver, K. M., Wright, J.P., DeLisi, M., Walsh, A., Vaughn, M. G., Boisvert, D., and Vaske, J.. 2007b. “A Gene × Gene Interaction between DRD2 and DRD4 Is Associated with Conduct Disorder and Antisocial Behavior in Males.” Behavior and Brain Functions 3: 30.CrossRefGoogle ScholarPubMed
Bell, Edward, Schermer, Julie Aitken, and Vernon, Philip A.. 2009. “The Origins of Political Attitudes and Behaviours: An Analysis Using Twins.” Canadian Journal of Political Science/Revue Canadienne de Science Politique 42 (4): 855–79.CrossRefGoogle Scholar
Berggren, Ulf, Fahlke, Claudia, Aronsson, Erik, Karanti, Aikaterini, Eriksson, Matts, Blennow, Kaj, Thelle, Dag, Zetterberg, Henrick, and Balldin, Jan. 2006. “The Taqi DRD2 A1 Allele Is Associated with Alcohol-dependence Although Its Effect Size Is Small.” Alcohol and Alcoholism 41 (5): 479–85.CrossRefGoogle ScholarPubMed
Beutler, E. 2001. “Discrepancies between Genotype and Phenotype in Hematology: An Important Frontier.” Blood 98 (9): 2597–2602.CrossRefGoogle Scholar
Bickeböller, Heike, Bailey, Julia N., Papanicolaou, George J., Rosenberger, Albert, and Viel, Kevin R.. 2005. “Dissection of Heterogeneous Phenotypes for Quantitative Trait Mapping.” Genetic Epidemiology 29 (S1): S41–47.CrossRefGoogle ScholarPubMed
Bobadilla, Joseph L., Macek, Milan Jr, Fine, Jason P., and Farrell, Philip M.. 2002. “Cystic Fibrosis: A Worldwide Analysis of CFTR Mutations-correlation with Incidence Data and Application to Screening.” Human Mutation 19 (6): 575–606.CrossRefGoogle ScholarPubMed
Bogardus, Clifton. 2009. “Missing Heritability and GWAS Utility.” Obesity 17 (2): 209–10.CrossRefGoogle ScholarPubMed
Boklage, Charles E. 2009. “Traces of Embryogenesis Are the Same in Monozygotic and Dizygotic Twins: Not Compatible with Double Ovulation.” Human Reproduction 24 (6): 1255–66.CrossRefGoogle ScholarPubMed
Bourgain, Catherine, Abney, Mark, Schneider, Dan, Ober, Carole, and McPeek, Mary Sara. 2004. “Testing for Hardy-Weinberg Equilibrium in Samples with Related Individuals.” Genetics 168 (4): 2349–61.CrossRefGoogle ScholarPubMed
Browning, Sharon R., Briley, J. David, Briley, Linda P., Chandra, Gyan, Charnecki, Jonathan H., Ehm, Margaret G., Johansson, Kelley A. et al. 2005. “Case-control Single-marker and Haplotypic Association Analysis of Pedigree Data.” Genetic Epidemiology 28 (2): 110–22.CrossRefGoogle ScholarPubMed
Bruder, C.E.G. 2008. “Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation Profiles.” American Journal of Human Genetics 82: 1–9.CrossRefGoogle ScholarPubMed
Cao, Y., Lu, H.M., and Liang, J.. 2010. “Probability Landscape of Heritable and Robust Epigenetic State of Lysogeny in Phage Lambda.” Proceedings of the National Academy of Science USA 107 (43): 18445–50.CrossRefGoogle ScholarPubMed
Cardon, L.R., and Palmer, L.J.. 2003. “Population Stratification and Spurious Allelic Association.” Lancet 361: 598–604.CrossRefGoogle ScholarPubMed
Carrel, Laura, and Willard, Huntington F.. 2005. “X-inactivation Profile Reveals Extensive Variability in X-linked Gene Expression in Females.” Nature 434 (7031): 400–04.CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, Joseph et al. 2003. “Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene.” Science 301 (5631): 386–89.CrossRefGoogle ScholarPubMed
Cassel, Carol A. 2003. “Overreporting and Electoral Participation Research.” American Politics Research 31 (1): 81–92.CrossRefGoogle Scholar
Cassel, Carol A. 2004. “Voting Records and Validated Voting Studies.” Public Opinion Quarterly 68 (1): 102–08.CrossRefGoogle Scholar
Cavalli-Sforza, L.L. 1994. The History and Geography of Human genes. Edited by Menozzi, P. and Piazza, A.. Princeton, N.J: Princeton University Press.Google Scholar
Cesarini, David, Dawes, Christopher T., Fowler, James H., Johannesson, Magnus, Lichtenstein, Paul, and Wallace, Björn. 2008. “Heritability of Cooperative Behavior in the Trust Game.” Proceedings of the National Academy of Sciences 105 (10): 3721–26.CrossRefGoogle ScholarPubMed
Chanock, Stephen J., Manolio, Teri, Boehnke, Michael, Boerwinkle, Eric, Hunter, David J., Thomas, Gilles, Hirschhorn, Joel N. et al. 2007. “Replicating Genotype-Phenotype Associations.” Nature 447 (7145): 655–60.Google ScholarPubMed
Childs, E., Hohoff, C., Deckert, J., Xu, K., Badner, J., and de Wit, H.. 2008. “Association between ADORA2A and DRD2 Polymorphisms and Caffeine-induced Anxiety.” Neuropsychopharmacology 33 (12): 2791–2800.CrossRefGoogle ScholarPubMed
Chipman, P., Jorm, A.F., Prior, M., Sanson, A., Smart, D., Tan, X., and Easteal, S.. 2007. “No Interaction between the Serotonin Transporter Polymorphism (5-HTTLPR) and Childhood Adversity or Recent Stressful Life Events on Symptoms of Depression: Results from Two Community Surveys.” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4): 561–65.CrossRefGoogle ScholarPubMed
Cirulli, Elizabeth T., and Goldstein, David B.. 2007. “In Vitro Assays Fail to Predict In Vivo Effects of Regulatory Polymorphisms.” Human Molecular Genetics 16 (16): 1931–39.CrossRefGoogle ScholarPubMed
Clay Montier, Laura L., Deng, Janice J., and Bai, Yidong. 2009. “Number Matters: Control of Mammalian Mitochondrial DNA Copy Number.” Journal of Genetics and Genomics 36 (3): 125–31.CrossRefGoogle ScholarPubMed
Comings, D.E. 1998. “Why Different Rules Are Required for Polygenic Inheritance: Lessons from Studies of the DRD2 Gene.” Alcohol 16 (1): 61–70.CrossRefGoogle ScholarPubMed
Comings, D.E., Muhleman, D., and Gysin, R.. 1996. “Dopamine D2 Receptor (DRD2) Gene and Susceptibility to Posttraumatic Stress Disorder: A Study and Replication.” Biological Psychiatry 40 (5): 368–72.CrossRefGoogle ScholarPubMed
Conrad, Donald F., Dalila, Pinto, Redon, Richard, Feuk, Lars, Gokcumen, Omer, Zhang, Yujun, Aerts, Jan et al. 2010. “Origins and Functional Impact of Copy Number Variation in the Human Genome.” Nature 464 (7289): 704–12.CrossRefGoogle ScholarPubMed
Cotton, R.G.H., and Horaitis, O.. 2002. “The HUGO Mutation Database Initiative.” Pharmacogenomics Journal 2 (1): 16–19.CrossRefGoogle ScholarPubMed
Coufal, Nicole G., Garcia-Perez, Jose L., Peng, Grace E., Yeo, Gene W., Mu, Yangling, Lovci, Michael T., Morrell, Maria, O'Shea, Sue, Moran, John V., and Gage, Fred H.. 2009. “L1 Retrotransposition in Human Neural Progenitor Cells.” Nature 460 (7259): 1127–31.CrossRefGoogle ScholarPubMed
Daw, J., and Guo, G.. 2011. “The Influence of Three Genes on Whether Adolescents Use Contraception, USA 1994-2002.” Population Studies 65 (3): 253–71.CrossRefGoogle ScholarPubMed
Dawes, Christopher T., and Fowler, James H.. 2009. “Partisanship, Voting, and the Dopamine D2 Receptor Gene.” Journal of Politics 71 (3): 1157–71.CrossRefGoogle Scholar
Dawkins, Richard. 2006. The Selfish Gene. New York: Oxford University Press.Google Scholar
Dear, Paul H. 2009. “Copy-number Variation: The End of the Human Genome?” Trends in Biotechnology 27 (8): 448–54.CrossRefGoogle ScholarPubMed
De Neve, Jan-Emmanuel, and Fowler, James H.. 2010. “The MAOA Gene Predicts Credit Card Debt.” Social Science Research Network. http://papers.ssrn.com/sol3/papers.cfm?abstract_id=1457224 (accessed November 10, 2011).CrossRefGoogle Scholar
Deckert, J., Catalano, M., Syagailo, Y.V., Bosi, M., Okladnova, O., DiBella, D., Nöthen, M.M. et al. 1999. “Excess of High Activity Monoamine Oxidase A Gene Promoter Alleles in Female Patients with Panic Disorder.” Human Molecular Genetics 8 (4): 621–24.CrossRefGoogle ScholarPubMed
DeLisi, Matt, Beaver, Kevin M., Vaughn, Michael G., and Wright, John Paul. 2009. “All in the Family.” Criminal Justice and Behavior 36 (11): 1187–97.CrossRefGoogle Scholar
Dick, D.M., Riley, B., and Kendler, K.S.. 2010. “Nature and Nurture in Neuropsychiatric Genetics: Where Do We Stand?” Dialogues in Clinical Neuroscience 12 (1): 7–23.CrossRefGoogle ScholarPubMed
Dipple, Katrina M., Phelan, James K., and McCabe, Edward R.B.. 2001. “Consequences of Complexity within Biological Networks: Robustness and Health, or Vulnerability and Disease.” Molecular Genetics and Metabolism 74 (1/2): 45–50.CrossRefGoogle ScholarPubMed
Doll, B.B., Hutchison, K.E., and Frank, M.J.. 2011. “Dopaminergic Genes Predict Individual Differences in Susceptibility to Confirmation Bias.” Journal of Neuroscience 31 (16): 6188–98.CrossRefGoogle ScholarPubMed
Eaves, Lindon, and Hatemi, Peter. 2008. “Transmission of Attitudes toward Abortion and Gay Rights: Effects of Genes, Social Learning, and Mate Selection.” Behavior Genetics 38 (3): 247–56.CrossRefGoogle ScholarPubMed
Edwards, Alexis, Rollmann, Stephanie M., Morgan, Theodore J., and Mackay, Trudy F.C.. 2006. “Quantitative Genomics of Aggressive Behavior in Drosophila Melanogaster.” PLoS Genetics 2 (9): e154.CrossRefGoogle ScholarPubMed
Edwards, Alexis, Ayroles, Julien, Stone, Eric, Carbone, Mary, Lyman, Richard, and Mackay, Trudy. 2009a. “A Transcriptional Network Associated with Natural Variation in Drosophila Aggressive Behavior.” Genome Biology 10 (7): R76: 1–11.CrossRefGoogle ScholarPubMed
Edwards, Alexis, , Liesbeth Zwarts, Yamamoto, Akihiko, , Patrick Callaerts, and Mackay, Trudy. 2009b. “Mutations in Many Genes Affect Aggressive Behavior in Drosophila Melanogaster.” BMC Biology 7 (1): 29.CrossRefGoogle ScholarPubMed
Emanuele, E., Brondino, N., Pesent, S., Re, S., and Geroldi, D.. 2007. “Genetic Loading on Human Loving Styles.” Neuroendocrinology Letters 28 (6): 815–21.Google ScholarPubMed
Esau, Luke, Kaur, Mandeep, Adonis, Lucinda, and Arieff, Zainunisha. 2008. “The 5-HTTLPR Polymorphism in South African Healthy Populations: A Global Comparison.” Journal of Neural Transmission 115 (5): 755–60.CrossRefGoogle ScholarPubMed
File, Thom, and Crissey, Sarah. 2010. “Voting and Registration in the Election of November 2008: Population Characteristics.” Washington, DC: U.S. Census Bureau. www.census.gov/prod/2010pubs/p20-562.pdf (Accessed November 10, 2011).Google Scholar
Flint, J., and Munafo, M.R.. 2007. “The Endophenotype Concept in Psychiatric Genetics.” Psychological Medicine 37: 163–80.CrossRefGoogle ScholarPubMed
Fowler, James H., Baker, Laura A., and Dawes, Christopher T.. 2008. “Genetic Variation in Political Participation.” American Political Science Review 102 (2): 233–48.CrossRefGoogle Scholar
Fowler, James H., and Dawes, Christopher T.. 2008. “Two Genes Predict Voter Turnout.” Journal of Politics 70 (3): 579–94.CrossRefGoogle Scholar
Fowler, James H., Settle, J.E., and Christakis, N.A.. 2011. “Correlated Genotypes in Friendship Networks.” Proceedings of the National Academy of Sciences USA 108 (5): 1993–97.CrossRefGoogle ScholarPubMed
Fowler, Joanna S., Alia-Klein, Nelly, Kriplani, Aarti, Logan, Jean, Williams, Benjamin, Zhu, Wei, Craig, Ian W. et al. 2007. “Evidence That Brain MAO A Activity Does Not Correspond to MAO A Genotype in Healthy Male Subjects.” Biological Psychiatry 62 (4): 355–58.CrossRefGoogle ScholarPubMed
Fraga, M.F., Ballesta, E., Paz, M.F., Ropero, S., and Setien, F.. 2005. “Epigenetic Differences Arise during the Lifetime of Monozygotic Twins.” Proceedings of the National Academy of Sciences USA 102: 10604-09.CrossRefGoogle ScholarPubMed
Franke, Barbara, Neale, Benjamin, and Faraone, Stephen. 2009. “Genome-wide Association Studies in ADHD.” Human Genetics 126 (1): 13–50.CrossRefGoogle ScholarPubMed
Frazzetto, Giovanni, Giorgio, Di Lorenzo, Carola, Valeria, Proietti, Luca, Sokolowska, Ewa, Siracusano, Alberto, Gross, Cornelius, and Troisi, Alfonso. 2007. “Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype.” PLoS ONE 2 (5): e486.CrossRefGoogle ScholarPubMed
Gottesman, I., and Shields, J.. 1973. “Genetic Theorizing and Schizophrenia.” British Journal of Psychiatry 122 (566): 15–30.CrossRefGoogle ScholarPubMed
Gressler, Sabine, and Haslberger, Alexander G., eds. 2010. Epigenetics and Human Health: Linking Hereditary, Environmental, and Nutritional Aspects. Weinheim, Germany: Wiley-VCH.Google Scholar
Grevle, L., Guzey, C., Hadidi, H., Brennersted, R., Idle, J.R., and Aasly, J.. 2000. “Allelic Association between the DRD2 TaqI A Polymorphism and Parkinson's Disease.” Movement Disorders 15 (6): 1070–74.3.0.CO;2-A>CrossRefGoogle Scholar
Guo, G., and Tillman, K.H.. 2009. “Trajectories of Depressive Symptoms, Dopamine D2 and D4 Receptors, Family Socioeconomic Status and Social Support in Adolescence and Young Adulthood.” Psychiatric Genetics 19 (1): 14–26.CrossRefGoogle ScholarPubMed
Guo, G., Roettger, M.E., and Shih, J.C.. 2007a. “Contributions of the DAT1 and DRD2 Genes to Serious and Violent Delinquency among Adolescents and Young Adults.” Human Genetics 121 (1): 125–36.CrossRefGoogle ScholarPubMed
Guo, Guang, Wilhelmsen, Kirk, and Hamilton, Nathan. 2007b. “Gene–lifecourse Interaction for Alcohol Consumption in Adolescence and Young Adulthood: Five Monoamine Genes.” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4): 417–23.CrossRefGoogle Scholar
Guo, G., and Tong, Y.. 2006. “Age at First Sexual Intercourse, Genes, and Social Context: Evidence from Twins and the Dopamine D4 Receptor Gene.” Demography 43 (4): 747–69.CrossRefGoogle ScholarPubMed
Halpern, Carolyn, Kaestle, Christine, Guo, Guang, and Hallfors, Denise. 2007. “Gene-environment Contributions to Young Adult Sexual Partnering.” Archives of Sexual Behavior 36 (4): 543—54.CrossRefGoogle ScholarPubMed
Haque, F. Nipa, Gottesman, Irving I., and Wong, Albert H.C.. 2009. “Not Really Identical: Epigenetic Differences in Monozygotic Twins and Implications for Twin Studies in Psychiatry.” American Journal of Medical Genetics Part C: Seminars in Medical Genetics 151C (2): 136–41.CrossRefGoogle ScholarPubMed
Hatemi, Peter K., Alford, John R., Hibbing, John R., Martin, Nicholas G., and Eaves, Lindon J.. 2009. “Is There a ‘Party’ in Your Genes?” Political Research Quarterly 62 (3): 584–600.CrossRefGoogle Scholar
Hatemi, Peter K., Medland, Sarah, Morley, Katherine, Heath, Andrew, and Martin, Nicholas. 2007. “The Genetics of Voting: An Australian Twin Study.” Behavior Genetics 37 (3): 435–48.CrossRefGoogle ScholarPubMed
Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., and Lesch, K.P.. 1996. “Allelic Variation of Human Serotonin Transporter Gene Expression.” Journal of Neurochemistry 66: 2621–24.CrossRefGoogle ScholarPubMed
Huizinga, David, Haberstick, Brett C., Smolen, Andrew, Menard, Scott, Young, Susan E., Corley, Robin P., Stallings, Michael C., Grotpeter, Jennifer, and Hewitt, John K.. 2006. “Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype.” Biological Psychiatry 60 (7): 677–83.CrossRefGoogle ScholarPubMed
Hunley, Keith L., Healy, Meghan E., and Long, Jeffrey C.. 2009. “The Global Pattern of Gene Identity Variation Reveals a History of Long-range Migrations, Bottlenecks, and Local Mate Exchange: Implications for Biological Race.” American Journal of Physical Anthropology 139 (1): 35–46.CrossRefGoogle ScholarPubMed
Jacob, Christian P., Muller, Johannes, Schmidt, Michael, Hohenberger, Katrin, Gutknecht, Lise, Reif, Andreas, Schmidtke, Armin, Mössner, Rainard, and Peter Lesch, Klaus. 2005. “Cluster B Personality Disorders Are Associated with Allelic Variation of Monoamine Oxidase A Activity.” Neuropsychopharmacology 30 (9): 1711–18.CrossRefGoogle ScholarPubMed
Jensen, O.N. 2004. “Modification-specific Proteomics: Characterization of Post-translational Modifications by Mass Spectrometry.” Current Opinions in Chemical Biology 8 (1): 33–41.CrossRefGoogle ScholarPubMed
Jirtle, Randy L., and Skinner, Michael K.. 2007. “Environmental Epigenomics and Disease Susceptibility.” Nature Reviews Genetics 8 (4): 253–62.CrossRefGoogle ScholarPubMed
Jonassaint, C.R, Ashely-Koch, A., Whitfield, K., and Williams, R.B.. 2008. “The Serotonin Transporter Gene Moderates Environmental Stress Effects on Self-esteem.” Presented at the American Psychosomatic Society. Baltimore. http://www.cpc.unc.edu/projects/addhealth/pubs/61863 (accessed November 10, 2011).Google Scholar
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I.W., and Moffitt, T.E.. 2006. “MAOA, Maltreatment, and Gene-environment Interaction Predicting Children's Mental Health: New Evidence and a Meta-analysis.” Molecular Psychiatry 11 (10): 903–13.CrossRefGoogle ScholarPubMed
Klein, T.A., Neumann, J., Reuter, M., Hennig, J., von Cramon, D.Y., and Ullsperger, M.. 2007. “Genetically Determined Differences in Learning from Errors.” Science 318 (5856): 1642–45.CrossRefGoogle ScholarPubMed
Kraft, P. 2008. “Curses-Winner's and Otherwise-in Genetic Epidemiology.” Epidemiology 19: 649–51.CrossRefGoogle ScholarPubMed
Lango Allen, Hana, Estrada, Karol, Lettre, Guillaume, Berndt, Sonja I., Weedon, Michael N., Rivadeneira, Fernando, Willer, Cristen J. et al. 2010. “Hundreds of Variants Clustered in Genomic Loci and Biological Pathways Affect Human Height.” Nature 467 (7317): 832–38.CrossRefGoogle ScholarPubMed
Larsen, Klaus, Holm Petersen, Jørgen, Budtz-Jørgensen, Esben, and Endahl, Lars. 2000. “Interpreting Parameters in the Logistic Regression Model with Random Effects.” Biometrics 56 (3): 909–14.CrossRefGoogle ScholarPubMed
Lesch, Klaus-Peter, Dietmar, Bengel, Heils, Armin, Sabol, Sue Z., Greenberg, Benjamin D., Petri, Susanne, Benjamin, J., Müller, C.R., Hamer, D.H., Murphy, Dennis L.. 1996. “Association of Anxiety-related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region.” Science 274 (5292): 1527–31.CrossRefGoogle ScholarPubMed
Lee, C.C., Chou, I.C., Tsai, C.H., Wang, T.R., Li, T.C., and Tsai, F.J.. 2005. “Dopamine Receptor D2 Gene Polymorphisms Are Associated in Taiwanese Children with Tourette Syndrome.” Pediatric Neurology 33 (4): 272–76.CrossRefGoogle ScholarPubMed
Lewontin, Richard C. 2000. The Triple Helix: Gene, Organism, and Environment. Cambridge, MA: Harvard University Press.Google Scholar
Lopez-Rodriguez, R., Roman, M., Novalbos, J., Pelegrina, M.L., Ochoa, D., and Abad-Santos, F.. 2011. “DRD2 Taq1A Polymorphism Modulates Prolactin Secretion Induced by Atypical Antipsychotics in Healthy Volunteers.” Journal of Clinical Psychopharmacology 31 (5): 555–62.CrossRefGoogle ScholarPubMed
Lotrich, Francis E., Pollock, Bruce G., and Ferrell, Robert E.. 2003. “Serotonin Transporter Promoter Polymorphism in African Americans: Allele Frequencies and Implications for Treatment.” American Journal of PharmacoGenomics 3 (2): 145–47.CrossRefGoogle ScholarPubMed
Machin, Geoffrey. 2009. “Non-identical Monozygotic Twins, Intermediate Twin Types, Zygosity Testing, and the Non-random Nature of Monozygotic Twinning: A Review.” American Journal of Medical Genetics Part C: Seminars in Medical Genetics 151C (2): 110–27.CrossRefGoogle ScholarPubMed
Manolio, Teri A., Collins, Francis S., Cox, Nancy J., Goldstein, David B., Hindorff, Lucia A., Hunter, David J., McCarthy, Mark I. et al. 2009. “Finding the Missing Heritability of Complex Diseases.” Nature 461 (7265): 747–53.CrossRefGoogle ScholarPubMed
Marchetto, Maria C.N., Gage, Fred H., and Muotri, Alysson R.. 2010. “Retrotransposition and Neuronal Diversity.” In Perspectives of Stem Cells: From Tools for Studying Mechanisms of Neuronal Differentiation towards Therapy, ed. H. Ulrich. Dordrecht, the Netherlands: Springer, 87–96.Google Scholar
MarchiniJ., L.R. Cardon J., L.R. Cardon, Phillips, M.S., and Donnelly, P.. 2004. “The Effects of Human Population Structure on Large Genetic Association Studies.” Nature Genetics 36: 512–17.CrossRefGoogle ScholarPubMed
Martin, Sandra L. 2009. “Developmental Biology: Jumping-gene Roulette.” Nature 460 (7259): 1087–88.CrossRefGoogle ScholarPubMed
McCabe, Linda L., and McCabe, Edward R.B.. 2006. “Complexity in Genetic Diseases: How Patients Inform the Science by Ignoring the Dogma.” American Journal of Medical Genetics Part A 140A (2): 160–61.CrossRefGoogle Scholar
McClellan, Jon, and King, Mary-Claire. 2010. “Genetic Heterogeneity in Human Disease.” Cell 141 (2): 210–17.CrossRefGoogle ScholarPubMed
McClernon, F. Joseph, Fuemmeler, Bernard F., Kollins, Scott H., Kail, Melanie E., and Ashley-Koch, Allison E.. 2008. “Interactions between Genotype and Retrospective ADHD Symptoms Predict Lifetime Smoking Risk in a Sample of Young Adults.” Nicotine and Tobacco Research 10 (1): 117–27.CrossRefGoogle Scholar
McCrae, Robert R., Scally, Matthew, Terracciano, Antonio, Abecasis, Gonçalo R., and Costa, Paul T. Jr. 2010. “An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-factor Model.” Journal of Personality and Social Psychology 99 (6): 1014–24.CrossRefGoogle Scholar
McDermott, Rose, Tingley, Dustin, Cowden, Jonathan, Frazzetto, Giovanni, and Johnson, Dominic D.P.. 2009. “Monoamine Oxidase A Gene (MAOA) Predicts Behavioral Aggression Following Provocation.” Proceedings of the National Academy of Sciences USA 106 (7): 2118–23.CrossRefGoogle ScholarPubMed
McIntosh, Hugh, Daniel, Hart, and Youniss, James. 2007. “The Influence of Family Political Discussion on Youth Civic Development: Which Parent Qualities Matter?” PS: Political Science and Politics 40 (3): 495–99.Google Scholar
Mehler, Mark F. 2008. “Epigenetics and the Nervous System.” Annals of Neurology 64 (6): 602–17.CrossRefGoogle ScholarPubMed
Mertins, V., Schote, A.B., Hoffeld, W., Griessmair, M., and Meyer, J.. 2011. “Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods.” PLoS ONE 6 (6): 16.CrossRefGoogle ScholarPubMed
Middeldorp, Christel, de Geus, Eco, Beem, A., Lakenberg, Nico, Hottenga, Jouke-Jan, Slagboom, P., and Boomsma, Dorret. 2007. “Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression.” Behavior Genetics 37 (2): 294–301.CrossRefGoogle ScholarPubMed
Migeon, Barbara R. 2007. Females Are Mosaics: X Inactivation and Sex Differences in Disease. Oxford: Oxford University Press.CrossRefGoogle ScholarPubMed
Morton, Newton E. 2005. “Linkage Disequilibrium Maps and Association Mapping.” Journal of Clinical Investigation 115 (6): 1425–30.CrossRefGoogle ScholarPubMed
Nagel, R.L. 2005. “Epistasis and the Genetics of Human Diseases.” Comptes Rendus Biologies 328 (7): 606–15.CrossRefGoogle ScholarPubMed
Naylor, L., Dean, B., Pereira, A., Mackinnon, A., Kouzmenko, A., and Copolov, D.. 1998. “No Association between the Serotonin Transporter-linked Promoter Region Polymorphism and Either Schizophrenia or Density of the Serotonin Transporter in Human Hippocampus.” Molecular Medicine 4 (10): 671–74.CrossRefGoogle ScholarPubMed
Need, A.C., and Goldstein, D.B.. 2010. “Whole Genome Association Studies in Complex diseases: where do we stand?” Dialogues in Clinical Neuroscience 12 (1): 37–46.CrossRefGoogle ScholarPubMed
Neuhaus, J.M., Hauck, W.W., and Kalbfleisch, J.D.. 1992. “The Effects of Mixture Distribution Misspecification When Fitting Mixed-effects Logistic Models.” Biometrika 79 (4): 755–62.CrossRefGoogle Scholar
Newman, Dina L., Abney, Mark, Sara McPeek, Mary, Ober, Carole, and Cox, Nancy J.. 2001. “The Importance of Genealogy in Determining Genetic Associations with Complex Traits.” American Journal of Human Genetics 69 (5): 1146–48.CrossRefGoogle ScholarPubMed
Nilsen, T.W., and Graveley, B.R.. 2010. “Expansion of the Eukaryotic Proteome by Alternative Splicing.” Nature 463 (7280): 457–63.CrossRefGoogle ScholarPubMed
Nisoli, E., Brunani, A., Borgomainerio, E., Tonello, C., Dioni, L., Briscini, L., Redaelli, G., Molinari, E., Cavagnini, F., and Carruba, M.O.. 2007. “D2 Dopamine Receptor (DRD2) Gene Taq1A Polymorphism and the Eating-related Psychological Traits in Eating Disorders (Anorexia Nervosa and Bulimia) and Obesity.” Eating and Weight Disorders 12 (2): 91–96.CrossRefGoogle ScholarPubMed
Noble, Denis. 2010. “Biophysics and Systems Biology.” Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368 (1914): 1125–39.CrossRefGoogle ScholarPubMed
Nordquist, Niklas, and Oreland, Lars. 2010. “Serotonin, Genetic Variability, Behaviour, and Psychiatric Disorders: A Review.” Upsala Journal of Medical Sciences 115 (1): 2–10.CrossRefGoogle ScholarPubMed
Notini, A.J., Craig, J.M., and White, S.J.. 2008. “Copy Number Variation and Mosaicism.” Cytogenetic and Genome Research 123 (1–4): 270–77.CrossRefGoogle ScholarPubMed
Nyman, Emma S., Loukola, Anu, Varilo, Teppo, Ekelund, Jesper, Veijola, Juha, Joukamaa, Matti, Taanila, Anja et al. 2009. “Impact of the Dopamine Receptor Gene Family on Temperament Traits in a Population-based Birth Cohort.” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (6): 854–65.CrossRefGoogle Scholar
Ollikainen, Miina, Smith, Katherine R., Ji-Hoon Joo, Eric, Kiat Ng, Hong, Andronikos, Roberta, Novakovic, Boris, Abdul Aziz, Nur Khairunnisa et al. 2010. “DNA Methylation Analysis of Multiple Tissues from Newborn Twins Reveals Both Genetic and Intrauterine Components to Variation in the Human Neonatal Epigenome.” Human Molecular Genetics 19 (21): 4176–88.CrossRefGoogle ScholarPubMed
Ooi, Lezanne, and Wood, Ian C.. 2008. “Regulation of Gene Expression in the Nervous System.” Biochemical Journal 414: 327–41.CrossRefGoogle ScholarPubMed
Paclt, I., Drtilkova, I., Kopeckova, M., Theiner, P., Sery, O., and Cermakova, N.. 2010. “The Association between TaqI A Polymorphism of ANKK1 (DRD2) Gene and ADHD in Czech Boys Aged between 6 and 13 Years.” Neuroendocrinology Letters 31 (1): 131–36.Google Scholar
Pai, Chung-Yen, Chou, Su-Lien, and Fu-Yuan Huang, Frank. 2007. “Assessment of the Role of a Functional VNTR Polymorphism in MAOA Gene Promoter: A Preliminary Study.” Forensic Science Journal 6 (2): 37–43.Google Scholar
Peltonen, Leena, and McKusick, Victor A.. 2001. “Dissecting Human Disease in the Postgenomic Era.” Science 291 (5507): 1224–29.CrossRefGoogle ScholarPubMed
Pergament, E. 2005. “Postnatal Zygosity Determination.” In Multiple Pregnancy: Epidemiology, Gestation, and Perinatal Outcome, eds. Blickstein, I. and Keith, L.G.. London: Parthenon, 393–402.Google Scholar
Petronis, Arturas. 2010. “Epigenetics as a Unifying Principle in the Aetiology of Complex Traits and Diseases.” Nature 465 (7299): 721–27.CrossRefGoogle ScholarPubMed
Plomin, Robert. 1990. “The Role of Inheritance in Behavior.” Science 248 (4952): 183–88.CrossRefGoogle ScholarPubMed
Plomin, Robert, and Davis, Oliver S.P.. 2009. “The Future of Genetics in Psychology and Psychiatry: Microarrays, Genome-wide Association, and Non-coding RNA.” Journal of Child Psychology and Psychiatry 50 (1/2): 63–71.CrossRefGoogle ScholarPubMed
Plutzer, Eric. 2002. “Becoming a Habitual Voter: Inertia, Resources, and Growth in Young Adulthood.” American Political Science Review 96 (1): 41–56.CrossRefGoogle Scholar
Power, Tom, Robert, Stewart, Ancelin, Marie-Laure, Jaussent, Isabelle, Malafosse, Alain, and Ritchie, Karen. 2010. “5-HTTLPR Genotype, Stressful Life Events, and Late-life Depression: No Evidence of Interaction in a French Population.” Neurobiology of Aging 31 (5): 886–87.CrossRefGoogle Scholar
Prichard, Z., Mackinnon, A., Jorm, A.F., and Easteal, S.. 2008. “No Evidence for Interaction between MAOA and Childhood Adversity for Antisocial Behavior.” American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 147B (2): 228–32.CrossRefGoogle ScholarPubMed
Redon, Richard, Ishikawa, Shumpei, Fitch, Karen R., Feuk, Lars, Perry, George H., Daniel Andrews, T., Fiegler, Heike et al. 2006. “Global Variation in Copy Number in the Human Genome.” Nature 444 (7118): 444–54.CrossRefGoogle ScholarPubMed
Risch, N., Herrell, R., Lehner, T., Liang, K.Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., and Merikangas, K.R.. 2009. “Interaction between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression A Meta-analysis.” Journal of the American Medical Association 301 (23): 2462–71.CrossRefGoogle ScholarPubMed
Sabol, S.Z., Hu, S., and Hamer, D.. 1998. “A Functional Polymorphism in the Monoamine Oxidase A Gene Promoter.” Human Genetics 103 (3): 273–79.CrossRefGoogle ScholarPubMed
Schnable, P.S., Ware, D., Fulton, R.S., Stein, J.C., Wei, F., Pasternak, S., Liang, Chengzhi et al. 2009. “The B73 Maize Genome: Complexity, Diversity, and Dynamics.” Science 326 (5956): 1112–15.CrossRefGoogle ScholarPubMed
Science Daily. 2008. Political Participation Is Partially Rooted in Genetic Inheritance. July 3. http://www.sciencedaily.com/releases/2008/07/080701083517.htm (accessed November 10, 2011).Google Scholar
Settle, Jaime E., Dawes, Christopher T., Christakis, Nicholas A., and Fowler, James H.. 2010. “Friendships Moderate an Association between a Dopamine Gene Variant and Political Ideology.” Journal of Politics 72 (4): 1189–98.CrossRefGoogle ScholarPubMed
Sgaramella, Vittorio, and Astolfi, Paola A.. 2010. “Somatic Genome Variations Interact with Environment, Genome and Epigenome in the Determination of the Phenotype: A Paradigm Shift in Genomics?” DNA Repair 9 (4): 470–73.CrossRefGoogle ScholarPubMed
Shahmoradgoli Najafabadi, M., Ohadi, M., Joghataie, M.T., Valaie, F., Riazalhosseini, Y., Mostafavi, H., Mohammadbeigi, Fariba, and Najmabadi, H.. 2005. “Association between the DRD2 A1 Allele and Opium Addiction in the Iranian Population.” American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 5 (1): 39–41.CrossRefGoogle Scholar
Shanahan, M.J., Erickson, L.D., Vaisey, S., and Smolen, A.. 2007. “Helping Relationships and Genetic Propensities: A Combinatoric Study of DRD2, Mentoring, and Educational Continuation.” Twin Research in Human Genetics 10 (2): 285–98.CrossRefGoogle ScholarPubMed
Shanahan, M.J., Vaisey, S., Erickson, L.D., and Smolen, A.. 2008. “Environmental Contingencies and Genetic Propensities: Social Capital, Educational Continuation, and Dopamine Receptor Gene DRD2.” American Journal of Semiotics 114 (86): S260–86.Google ScholarPubMed
Shioe, K., Ichimiya, T., Suhara, T., Takano, A., Sudo, Y., Yasuno, F., Hirano, Masami et al. 2003. “No Association between Genotype of the Promoter Region of Serotonin Transporter Gene and Serotonin Transporter Binding in Human Brain Measured by PET.” Synapse 48 (4): 184–88.CrossRefGoogle ScholarPubMed
Skipper, Magdalena. 2008. “Human Genetics: Not-so-identical Twins.” Nature Reviews Genetics 9: 250–51.CrossRefGoogle Scholar
Slatkin, Montgomery. 2009. “Epigenetic Inheritance and the Missing Heritability Problem.” Genetics 182 (3): 845–50.CrossRefGoogle ScholarPubMed
Squassina, A., Manchia, M., Costa, M., Chillotti, C., Ardau, R., Del Zompo, M., and Severino, G.. 2011. “Age at Onset in Bipolar Disorder: Investigation of the Role of TaqIA Polymorphism of DRD2 Gene in a Sardinian Sample.” European Psychiatry 26 (3): 141–43.CrossRefGoogle Scholar
Stephens, J. Claiborne, Schneider, Julie A., Tanguay, Debra A., Choi, Julie, Acharya, Tara, Stanley, Scott E., Jiang, Ruhong et al. 2001. “Haplotype Variation and Linkage Disequilibrium in 313 Human Genes.” Science 293 (5529): 489–93.CrossRefGoogle ScholarPubMed
Stöber, Gerald, Syagailo, Yana V., Okladnova, Olga, Jungkunz, Gerd, Knapp, Michael, Beckmann, Helmut, and Lesch, Klaus-Peter. 1999. “Functional PAX-6 Gene-linked Polymorphic Region: Potential Association with Paranoid Schizophrenia.” Biological Psychiatry 45 (12): 1585–91.CrossRefGoogle ScholarPubMed
Suda, A., Kawanishi, C., Kishida, I., Sato, R., Yamada, T., Nakagawa, M., Hasegawa, H., Kato, D., Furuno, T., and Hirayasu, Y.. 2009. “Dopamine D2 Receptor Gene Polymorphisms Are Associated with Suicide Attempt in the Japanese Population.” Neuropsychobiology 59 (2): 130–34.CrossRefGoogle ScholarPubMed
Talmud, Philippa J., Hingorani, Aroon D., Cooper, Jackie A., Marmot, Michael G., Brunner, Eric J., Kumari, Meena, Kivimäki, Mika, and Humphries, Steve E. 2010. “Utility of Genetic and Non-genetic Risk Factors in Prediction of Type 2 Diabetes: Whitehall II Prospective Cohort Study.” British Medical Journal 340.CrossRefGoogle ScholarPubMed
Tao, Y., Zheng, X., and Sun, Y.. 2007. “Effect of Feedback Regulation on Stochastic Gene Expression.” Journal of Theoretical Biology 247: 827–36.CrossRefGoogle ScholarPubMed
Turkheimer, Eric. 2000. “Three Laws of Behavior Genetics and What They Mean.” Current Directions in Psychological Science 9 (5): 160–64.CrossRefGoogle Scholar
Vaske, Jamie, Makarios, Matthew, Boisvert, Danielle, Beaver, Kevin M., and Paul Wright, John. 2009a. “The Interaction of DRD2 and Violent Victimization on Depression: An Analysis by Gender and Race.” Journal of Affective Disorders 112 (1): 120–25.CrossRefGoogle ScholarPubMed
Vaske, Jamie, Newsome, J., Makarios, M., Wright, J. P., Boutwell, B. B., and Beaver, K. M.. 2009b. “Interaction of 5HTTLPR and Marijuana Use on Property Offending.” Biodemography and Social Biology 55 (1): 93–102.CrossRefGoogle ScholarPubMed
Vaughn, Michael G., Beaver, Kevin M., DeLisi, Matt, Perron, Brian E., and Schelbe, Lisa. 2009. “Gene-environment Interplay and the Importance of Self-control in Predicting Polydrug Use and Substance-related Problems.” Addictive Behaviors 34 (1): 112–16.CrossRefGoogle ScholarPubMed
Wachtel, Stephen S. 1994. Molecular Genetics of Sex Determination. San Diego, CA: Academic Press.Google Scholar
Walter, N.T., Markett, S.A., Montag, C., and Reuter, M.. 2011. “A Genetic Contribution to Cooperation: Dopamine-relevant Genes Are Associated with Social Facilitation.” Social Neuroscience 6 (3): 289–301.CrossRefGoogle ScholarPubMed
Walters, Ryan D., Kugel, Jennifer F., and Goodrich, James A.. 2009. “Invaluable Junk: The Cellular Impact and Function of Alu and B2 RNAs.” IUBMB Life 61 (8): 831–37.CrossRefGoogle ScholarPubMed
Weatherall, David J. 2000. “Science, Medicine, and the Future: Single Gene Disorders or Complex Traits: Lessons from the Thalassaemias and Other Monogenic Diseases.” British Medical Journal 321 (7269): 1117–20.CrossRefGoogle ScholarPubMed
Whitelaw, N.C., and Whitelaw, E.. 2006. “How Lifetimes Shape Epigenotype within and across Generations.” Human Molecular Genetics 15: R131-37.CrossRefGoogle Scholar
Willeit, M., Stastny, J., Pirker, W., Praschak-Rieder, N., Neumeister, A., Asenbaum, S., Tauser, J. et al. 2001. “No Evidence for In Vivo Regulation of Midbrain Serotonin Transporter Availability by Serotonin Transporter Promoter Gene Polymorphism.” Biological Psychiatry 50 (1): 8–12.CrossRefGoogle ScholarPubMed
Williams, R.B., Marchuk, D.A., Gadde, K. M., Barefoot, J.C., Grichnik, K., Helms, M.J., Kuhn, C.M. et al. 2003. “Serotonin-related Gene Polymorphisms and Central Nervous System Serotonin Function.” Neuropsychopharmacology 28 (3): 533–41.CrossRefGoogle ScholarPubMed
Wojczynski, Mary K., and Tiwari, Hemant K.. 2008. “Definition of Phenotype.” Advances in Genetics 60: 75–105.CrossRefGoogle ScholarPubMed
Xu, H., and Shete, S.. 2007. “Mixed-effects Logistic Approach for Association following Linkage Scan for Complex Disorders.” Annals of Human Genetics 71 (2): 230–37.CrossRefGoogle ScholarPubMed
Young, Susan E., Smolen, Andrew, Hewitt, John K., Haberstick, Brett C., Stallings, Michael C., Corley, Robin P., and Crowley, Thomas J.. 2006. “Interaction between MAO-A Genotype and Maltreatment in the Risk for Conduct Disorder: Failure to Confirm in Adolescent Patients.” American Journal of Psychiatry 163 (6): 1019–25.CrossRefGoogle ScholarPubMed
Zhu, Qin-shi, and Chen Shih, Jean. 1997. “An Extensive Repeat Structure Down-regulates Human Monoamine Oxidase A Promoter Activity Independent of an Initiator-Like Sequence.” Journal of Neurochemistry 69 (4): 1368–73.CrossRefGoogle ScholarPubMed
Zuo, Yantao, Gilbert, David G., Rabinovich, Norka E., Riise, Hege, Needham, Rachel, and Huggenvik, Jodi I.. 2009. “DRD2-related TaqIA Polymorphism Modulates Motivation to Smoke.” Nicotine and Tobacco Research 11 (11): 1321–29.CrossRefGoogle ScholarPubMed
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