Interest in African studies has long been an established tradition of Duquesne University and its founders, the Fathers of the Congregation of the Holy Ghost, who began missionary work in Africa in the year 1778. By this tradition, books on Africa have been treasured ever since the University Library came into existence.

In November 1956, with the inauguration of the new Institute of African Affairs at Duquesne, special efforts were made to develop the collection to include large quantities of government documents, serial publications and books, and to enlist the active interest and assistance of Holy Ghost Fathers in obtaining and preserving material on Africa. The initial steps taken were all well received. Invaluable source materials poured in from the continent of Africa and from all over the world. This greatly strengthened the original collection.