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In Vivo X-Ray Fluorescence of Bone Lead in the Study of Human Lead Metabolism: Serum Lead, Whole Blood Lead, Bone Lead, and Cumulative Exposure

Published online by Cambridge University Press:  06 March 2019

K.M. Cake ,
D.R. Chettle ,
C.E. Webber ,
C.L. Gordon ,
R.J. Bowins ,
R.H. McNutt  and
C. Vaillancourt
K.M. Cake
Affiliation:
Department of Physics and Astronomy, McMaster University, Hamilton Ontario, LSS 4M1, Canada
D.R. Chettle
Affiliation:
Department of Physics and Astronomy, McMaster University, Hamilton Ontario, LSS 4M1, Canada
C.E. Webber
Affiliation:
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Box 2000 Station A, Hamilton, Ontario, L8N 3Z5, Canada
C.L. Gordon
Affiliation:
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Box 2000 Station A, Hamilton, Ontario, L8N 3Z5, Canada
R.J. Bowins
Affiliation:
Department of Geology, McMaster University
R.H. McNutt
Affiliation:
Department of Geology, McMaster University
C. Vaillancourt
Affiliation:
Medical Adviser, Nova Pb Inc., 1200 rue Gamier, Ville-Ste-Catherine Quebec, J0L 1E0, Canada
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Extract

Traditionally, clinical studies of lead's effect on health have relied on blood lead levels to indicate lead exposure. However, this is unsatisfactory because blood lead levels have a half-life of approximately 5 weeks (Rabinowitz et al., 1976), and thus reflect recent exposure. Over 90% of the lead body burden is in bone, and it is thought to have a long residence time, thus implying that measurements of bone lead reflect cumulative exposure (Barry, 1975). So, measurements of bone lead are useful m understanding the long-term health effects of lead.

Type
VIII. In Vivo Applications of XRS
Information
Advances in X-Ray Analysis , Volume 38: Forty-third Annual Conference on Applications of X-ray Analysis , 1994 , pp. 601 - 606
Copyright
Copyright © International Centre for Diffraction Data 1994

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References

Ahlgren, L., Liden, K., Mattsson, S., Tejning, S., “X-ray fluorescence analysis of lead in human skeleton in vivo” Scandinavian Journal of Work, Environment and Health 2, 82–86 1976.Google Scholar
PS.L Barry, “Comparison of concentrations of lead inhuman tissues” British Journal of Industrial Medicine 32, 119–139, 1975.Google Scholar
Armstrong, R., Chettle, D.R., Scott, M.C., L.J, Somervaille, Pendlington, M., “Repeated measurements of tibia lead by in vivo x-ray fluorescence in occupational exposure” British Journal of Industrial Medicine 49, 14–16, 1992.Google Scholar
RJ., Bowins, R.H., McNutt, “Electrothermal isotope dilution inductively coupled plasma mass spectrometry method for the determination of sub-ng levels of lead in human plasma” Journal of Analytical Atomic Speclrometiy 9, 1233–1236, 1994.Google Scholar
Erkkila, J., Armstrong, R., Riihimaki, V., Chettle, D.R., Paakkari, A., Scott, M., Somervaille, L., Starck, J., Kock, B., Aitio, A., “In vivo measurements of lead in bone at four anatomical sites: long term occupational and consequent endogenous exposure,” British Journal of Industrial Medicine 49, 631–644, 1992.Google Scholar
Gerhardsson, L., R., Attewell, Chettle, D.R., Englyst, Y., Lundstrom, N.G., Nordberg, G.E, Nyhlin, H., Scott, M.C., Todd, A.C., “In vivo measurements of lead in bone in long-term exposed lead smelter workers,” Archives of Environmental Health 48, 147–156, 1993.Google Scholar
Gordon, C.L., Chettle, D.R., Webber, C.E., ‘An improved instrument for the in vivo detection of bone lead,” British Journal of Industrial Medicine 50, 637–641 1993.Google Scholar
Hu, H., Pepper, L., Goldman, R., “Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone,” American Journal of Industrial Medicine 20, 723–735, 1991.Google Scholar
Manton, W.I., Cook, J.D., “High accuracy (stable isotope dilution) measurements of lead in serum and cerebrospinal fluid,” British Journal of Industrial Medicine 41, 313–319, 1934.Google Scholar
Rabinowitz, M.B., Wetherilt, G.W., Kopple, J.D., “Kinetic analysis of lead metabolism in healthy humans/’ Journal of Clinical Investigation 58, 260–270 1976.Google Scholar
Snedecor, G.W., Cochran, W.G., Statistical Methods, 8th ed, Iowa State University Press, Ames, Iowa, 1989.Google Scholar
Somervaille, L.J., Chettle, D.R., Scott, M.C., “In Vivo Measurement of Lead in Bone Using X-ray Fluorescence,” Physics in Medicine and Biology 30, 929–943, 1985.Google Scholar
Somervaille, L.J., Chettle, D.R., Scott, M.C., Tennant, D.R., McKiernan, M.J., Skilbeck, A., Trethowan, WN., “In Vivo Tibia Lead Measurements as an Index of Cumulative Exposure in Occupational Exposed Subjects,” British Journal of Industrial Medicine 45, 174–181, 1988.Google Scholar
Tbdd, A.C., McNeill, EE., Palethorpe, J.E., Peach, D.E., Chettle, D.R., Tobin, M.J., Strosko, S.J., Rosen, J.C., “In vivo XRF of lead in bone using K x-ray excitation with “Cd sources: radiation dosimetry studies,” Environmental Research 57, 117–132, 1992.Google Scholar