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In Vivo X-Ray Fluorescence Analysis for Medical Diagnosis

Published online by Cambridge University Press:  06 March 2019

L. Ahlgren
Affiliation:
Radiation Physics Department, University of Lund, S-221 85 Lund, Sweden
T. Grönberg
Affiliation:
Radiation Physics Department, University of Lund, S-221 85 Lund, Sweden
S. Mattsson
Affiliation:
Radiation Physics Department, University of Lund, S-221 85 Lund, Sweden
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Extract

Occupational exposure to lead is common in many industrial applications and hence it is of considerable medical interest to control the body-burden of lead in living man. More than 90 % of the lead in the body is concentrated in bone and hence in vivo measurements of the lead in the skeleton should give the most satisfactory way for estimating the body-burden. The routine method used today for checking on lead contamination is that of measurements on blood samples. However, since the concentration of lead in the blood is a sensitive function of the actual exposure conditions, this method provides only a poor indication of the total body-burden and the integrated lead exposure.

Type
Other XRF Applications
Copyright
Copyright © International Centre for Diffraction Data 1979

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References

1. Hoffer, P. B., Jones, W. B., Crawford, R. B., Beck, R. and Gottschalk, A., Fluorescent thyroid scanning: A new method of imaging the thyroid, Radiology 90, 342344 (1968).Google Scholar
2. Ahlgren, L. and Mattsson, S., An X-ray fluorescence technique for in vivo determination of lead concentration in a bone matrix, Phys. Med, Biol. 24, 136145 (1979).Google Scholar
3. Barry, P. S. I., Distribution and storage of lead in human tissues, in: The biogeochemistry of lead in the environment, Part B, Biological effects. Ed. by Nriagu, J. O., Amsterdam 1.978 pp. 97150.Google Scholar
4. Ahlgren, L., Haeger-Aronsen, B., Mattsson, S. and Schutz, A., In vivo determination of lead in the skeleton following occupational exposure, Accepted for publ. in Br J. Ind. Med.Google Scholar
5. Friberg, L., Piscator, M., Nordberg, G. F. and Kjellstrom, T., Cadmium in the environment, Second edition. CRC Press, Cleveland, Ohio U.S.A., 1974.Google Scholar
6. Grönberg, T., Almen, T., Golman, K., Lidén, K., Mattsson, S. and Sjöberg, S., Noninvasive determination of kidney function by X-ray fluorescence analysis (in preparation).Google Scholar
7. Ellis, K. J., Vartsky, D. and Cohn, S. H., A mobile promptgamma in vivo neutron activation facility, in: Symp. Nucl. Activation Techniques in the Life Sciences, Vienna, 22-26 May 1978, IAEA, Vienna, 1979, Paper IAEA SM-227/78.Google Scholar
8. Rossi, H. H., A proposal for revision of the quality factor, Rad. and Environm. Biophys. 14, 275283 (1977).Google Scholar
9. Thomson, J. F., Allen, K. H. and Fry, R. J. M. et al, Life shortening after exposure to neutrons and gamma rays, Annual Report 1977, Division of Biological and Medical Research, Report ANL-78-90, Argonne National Laboratory, Argonne, Illinois, U.S.A. pp 92-94 (1978).Google Scholar