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Application of Total Reflection X-Ray Fluorescence Spectrometry to Drug Analysis

Published online by Cambridge University Press:  06 March 2019

S. Nomura ,
T. Minomiya ,
K. Tanlguchi  and
S. Ikeda
S. Nomura
Affiliation:
Osaka Electro-Communication University, Osaka, Japan
T. Minomiya
Affiliation:
Hyogo Pref. Police H.Q., Hyogo, Japan
K. Tanlguchi
Affiliation:
Osaka Electro-Communication University, Osaka, Japan
S. Ikeda
Affiliation:
Ryukoku University, Shiga, Japan
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Abstract

A new procedure for indirect determination of pharmaceutical drugs is presented. The procedure consists of extracting ion pairs between organic basic compounds, that is, pharmaceutical drugs and cobalt tetrathiocyanate and of determining Co contents in the organic extraction phase using total reflection X-ray fluorescence spectrometry. Quinine, papaverine and pilocarpine are used as pharmaceutical drugs and 1,2-dichloroethane is adopted as extraction medium. Quinine cobalt tetrathiocyanate complex was isolated and was analyzed by FT-IR (Fourier Transform Infra-Red spectroscopy) suggested that approximately 4 ng of quinine could be detected by 1 μl of sampling of organic phase under ideal conditions using total reflection X-ray fluorescence spectrometry. These drugs have their own optimal pH for extraction. This technique can be applied to cocaine analysis.

Type
XII. Total Reflection XRS
Information
Advances in X-Ray Analysis , Volume 35 , Issue B: First Pacific-International Congress on X-ray Analytical Methods (PICXAM). Fortieth Annual Conference on Applications of X-ray Analysis, August 7-16, 1991 , 1991 , pp. 969 - 974
Copyright
Copyright © International Centre for Diffraction Data 1991

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References

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