Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-22T17:09:10.376Z Has data issue: false hasContentIssue false

In Vivo Measurements of Mercury Using X-Ray Fluorescence Analysis

Published online by Cambridge University Press:  06 March 2019

J. Börjesson
Affiliation:
Department of Radiation Physics, University of Göteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden Department of Radiation Physics, Lund University, Malmö University Hospital, S-214 01 Malmö, Sweden
L. Barregård
Affiliation:
Department of Occupational Medicine, University of Göteborg, Sahlgren Hospital, S-413 45, Göteborg, Sweden
G. Sällsten
Affiliation:
Department of Occupational Medicine, University of Göteborg, Sahlgren Hospital, S-413 45, Göteborg, Sweden
A. Schütz
Affiliation:
Department of Occupational and Environmental Medicine, Lund University, University Hospital, S-221 85 Lund, Sweden
R. Jonson
Affiliation:
Department of Radiation Physics, University of Göteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
M. Apsten
Affiliation:
Department of Radiation Physics, University of Göteborg, Sahlgren Hospital, S-413 45 Göteborg, Sweden
S. Mattsson
Affiliation:
Department of Radiation Physics, Lund University, Malmö University Hospital, S-214 01 Malmö, Sweden
Get access

Abstract

In this study we present the results of in vivo measurements of the mercury concentration in organs of occupationally exposed persons by the use of X-ray fluorescence analysis (XRF). The mercury concentration in the right kidney was measured in 20 occupationally exposed workers and 12 referents. The detection limit for the individual persons varied with the kidney depth (mean 26 μg/g, range 12-45 μg/g), was exceeded in nine of the exposed workers but in none of the referents. The mean kidney mercury concentration (including estimated concentration values below the detection limit) was 24 μg/g in the group of exposed workers (group MDC 5 μg/g) and for the group of referents no detectable concentration (mean 1 μg/g) was found (group MDC 6 μg/g). The mean urinary mercury excretions for the two groups were 34 and 1.7 μg per g creatinine. X-ray fluorescence measurements made on liver (n = 10) and thyroid (n = 8), in some of the exposed workers, revealed no measurable mercury concentrations.

Type
VIII. In Vivo Applications of XRS
Copyright
Copyright © International Centre for Diffraction Data 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berlin, M. Dose-response relations and diagnostic indices of mercury concentrations in critical organs upon exposure to mercury and mercurials. In: Effects and dose-response relationships of toxic metals (Nordberg GF; ed.) Elsevier, Amsterdam, Holland, 1976:235245.Google Scholar
Bloch, P, Shapiro, IM. An X-ray fluorescence technique to measure the mercury burden of dentists in vivo. Med Phys 1981;8:308311.Google Scholar
Borjesson, J. Measurements of platinum, gold and mercury in vivo: An analysis of the Goteborg XRF in vivo measurement system. Improvements, tests and patient measurements. Fil. lie. thesis, Dept. of Radiation Physics, University of Goteborg, Sweden (1991).Google Scholar
Borjesson, J, Alpsten, M, Huang, S, Jonscn, R, Mattsson, S, Thornberg, C. In vivo X-ray fluorescence analysis with applications to platinum, gold and mercury in man —experiments, improvements and patient measurements. In: Methods on In vivo Body Composition Assessment (Ellis KJ and Eastman J; eds.), Plenum Publishing Corporation, New York, USA, 1993:275280.Google Scholar
Borjesson, J, Jarup, L, Bellander, T, Elinder, CG, Mattsson, S. In vivo measurements of cadmium in liver and kidney of workers from a nickel-cadmium battery factory (in manuscript 1994).Google Scholar
Christ offersson, JO, Mattsson, S. Polarised X-rays in XRF analysis for improved in vivo detectability of Cd in man. Phys Med Biol 1983; 28: 11351144.Google Scholar
Fukuda, K. Metallic mercury induced tremor in rabbits and mercury content of the central nervous system. Br J Ind Med 1971;28:308311.Google Scholar
Jonson, R, Mattsson, S, Unsgaard, B. In vivo determination of platinum concentration after cisplatin therapy of testicular carcinoma. In: Recent advances in chemotherapy (Ishigami J; ed.), The University of Tokyo Press, 1985:12221224.Google Scholar
Jonson, R, Mattsson, S, Unsgaard, B. A method for in vivo analysis of platinum after chemotherapy with cisplatin. Phys Med Biol 1988;33:847857.Google Scholar
Kazailtzis, G, Schiller, KFR, Asscher, AW Drew, RG. Albuminuria and the nephrotic syndrome following exposure to mercury and its compounds. Q J Med 1962;31:409413.Google Scholar
Kosta, L, Byrne, AR, Zelenko, V Correlation between selenium and mercury in man following exposure to inorganic mercury. Nature 1975; 254: 238239.Google Scholar
Matsuo, N, Suzuki, X Akagi, H, Mercury concentration in organs of contemporary Japanese. Arch Environ Health 1989;44: 298303.Google Scholar
Nilsson, U. Quantitative in vivo elemental analysis using X-ray fluorescence and scattering techniques. Applications to cadmium lead and bone mineral. Thesis, Department of Radiation Physics, Lund University, Allmanna sjukhuset, Malmo, Sweden (1994).Google Scholar
Nylander, M, Weiner, J. Mercury and selenium concentrations and their inter-relationships in organs from dental staff aud the genera! population. Br J Ind Med 1991;48:729734.Google Scholar
Roels, H, Abdeladim, S, Ceulemans, E, Lauwerys, R. Relationships between the concentrations of mercury in air and in blood or urine in workers exposed to mercury vapour. Ann Occup Hyg 1987;31:135145.Google Scholar
Rossi, LC, Clemente, GF, Santaroni, G. Mercury and selenium distribution in a defined area and its population. Arch Environ Health 1976;31:160165.Google Scholar
Shakeshaft, J, Lillicrap, SC. An X-ray fluorescence system for the determination of gold in vivo following chrysotherapy. Br J Rad 1993;66:714717.Google Scholar
Skerfving, S, Christoffersson, J-O, Schtitz, A, Welinder, H, Spang, G, Ahlgren, L, Mattsson, S. Biological monitoring, by In vivo XRF measurements, of occupational exposure to lead, cadmium, and mercury, Biol Trace Element Res 1987;13:241251.Google Scholar
Sallsten, G, Barrcgard, L, Jarvholm, B. Mercury in the Swedish chloralkali industry—an evaluation of the exposure and preventive measures over 40 years. Ann Occup Hyg 1990;34:205214.Google Scholar
Sallsten, G, Barregard, L, Langworth, S, Vesterberg, O. Exposure to mercury in industry and dentistry—A field comparison between active and passive samplers (SKC). Appl Occup Environ Hyg 1992;7:434440.Google Scholar
Takahata, N, Hayashi, H, Watanabe, B, Anso, T Accumulation of Mercury in the brains of two autopsy cases with chronic inorganic Hg poisoning. Folia Psychiatr Neurol Jpn 1970;24:5969.Google Scholar
Warfinge, K, Hua, J, Berlin, M. Mercury distribution in the rat brain after mercury vapor exposure. Toxicol Appl Pharmacol 1992;117:4652.Google Scholar
World Health Organization (WHO). Environmental Health Criteria 118. Inorganic mercurv. Geneva, WHO, 1991.Google Scholar
Yoshida, M, Shimado, E. Arai F, Yamamura, Y. The relation between mercury levels in brain and blood or cerebrospinal fluid (CSF) after mercury exposure. J Toxicol Sci 1980;5:243250.Google Scholar