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Charged Particle Induced X-Ray Analysis of Malaria Infected Blood

Published online by Cambridge University Press:  06 March 2019

B. K. Barnes ,
R. M. Coleman ,
G. H. R. Kegel ,
P. W. Quinn  and
N. J. Rencricca
B. K. Barnes
Affiliation:
Lowell Technological Institute, Lowell, Mass. 01854
R. M. Coleman
Affiliation:
Lowell Technological Institute, Lowell, Mass. 01854
G. H. R. Kegel
Affiliation:
Lowell Technological Institute, Lowell, Mass. 01854
P. W. Quinn
Affiliation:
Lowell Technological Institute, Lowell, Mass. 01854
N. J. Rencricca
Affiliation:
Lowell Technological Institute, Lowell, Mass. 01854
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Abstract

Blood samples from normal and Plasmodium berghei infected mice are being analyzed for trace elements by charged particle induced x-rays. Approximately 0.25 ml of the sample (whole blood, washed red cells, or plasma) is dry ashed. The ashes are mounted on a 0.003 inch Kapton foil. The analysis is performed by bombardment of the samples by a beam of 2.0 MeV protons and detection of the characteristic x-rays by a 175-eV-resolution lithium-drifted silicon detector. The data are analyzed by an on-line PDP-9 computer-based data acquisition system. Results indicate an increase in the K, Ca, Cu, and Zn per unit volume of the red cells of the malaria infected mice relative to the amounts measured for uninfected blood, and a decrease in the K, Ca, and Fe and an increase in the Cu per unit volume in the plasma of the infected mice.

Type
Research Article
Information
Advances in X-Ray Analysis , Volume 18: Twenty-Third Annual Conference on Applications of X-ray Analysis, August 7-9, 1974 , 1974 , pp. 343 - 352
Copyright
Copyright © International Centre for Diffraction Data 1974

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References

1. Cooper, J. A., “Comparison of Particle and Photon Excited X-Ray Fluorescence applied to Trace Element Measurements of Environmental Samples”, Nuclear Instruments and Methods 106, 525–538, (1973).Google Scholar
2.Type H. Kapton polyimide film, E. I. DuPont deflemours and Company, Wilmington, Delaware.Google Scholar
3. Gordon, B. M. and Kramer, H. W., “Trace Element Analysis by Charged Particle induced X-rays”, BNL 15 931.Google Scholar
4. Umbarger, C. J., Bearse, R. C., Close, D. A., and Malanify, J. J., “Sensitivity and Detectability Limits for Elemental Analysis by Proton Induced X-Ray Fluorescence with a 3 MV Van de Graaff”, Advances in X-Ray Analysis, Vol. 16, 102–110 (1973).Google Scholar
5. Morrison, G. H. and Skogerboe, R. K., “General Aspects of Trace Analysis”, TRACE ANALYSIS, physical Methods, G- H. Morrison, Editor, Interscience Publishers (1965).Google Scholar
6. Gorsuch, T. T., “Radiochemical Investigations on the Recovery for Analysis of Trace Elements in Organic and Biological Material”, Analyst 84, 135 (1959).Google Scholar
7. Ong, P. S., Lund, P. K., Litton, C. E., and Mitchell, B. A., “An Energy Dispersive System for the Analysis of Trace Elements in Human 01ood Serum”, Advances in X-Ray Analysis, Vol. 16, 124–133 (1973).Google Scholar