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Prevention of relapse and recurrence of depression: newer versus older antidepressants

Published online by Cambridge University Press:  02 January 2018

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In a 17- to 19-year follow-up study it was shown that patients admitted to the Maudsley Hospital, London (whose index episode marked their first psychiatric contact) had a 50% chance of readmission during their lifetime; those with previous admissions had a similar chance of readmission within three years. Less than one-fifth of the patients had remained well, and over one-third suffered severe chronic distress and handicap or had died unnaturally (Lee & Murray, 1988). Similar gloomy pictures were reported in a 15-year follow-up study of patients in London and Sydney (Kiloh et al, 1988) and an 11-year follow-up study of patients in Montreal (Lehmann et al, 1988). As a result of such findings, much emphasis is now put on the importance of continuation and maintenance treatment of depression.

Type
Research Article
Copyright
Copyright © The Royal College of Psychiatrists 1997 

References

Anderson, I. (1997) Lessons to be learnt from meta-analyses of newer versus older antidepressants. Advances in Psychiatric Treatment, 3, 5762.CrossRefGoogle Scholar
Anderson, I. & Tomenson, B. M. (1995) Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: A meta-analysis. British Medical Journal, 310, 14331438.CrossRefGoogle ScholarPubMed
Anton, S. F., Robinson, D. S., Roberts, D. L. et al (1994) Long-term treatment of depression with nefazodone. Psychopharmacology Bulletin, 30, 165169.Google ScholarPubMed
Donovan, S., McGrady, H., Pownall, R. et al (1993) The efficacy and tolerability of dothiepin and three selective serotonin reuptake inhibitors in the treatment of major depression: A review of double-blind studies. Current Therapeutic Research, 54, 275288.CrossRefGoogle Scholar
Doogan, D. P. & Caillard, V. (1992) Sertraline in the prevention of depression. British Journal of Psychiatry, 160, 217222.CrossRefGoogle ScholarPubMed
Dunbar, G. C., Cohn, J. B., Fabre, L. F. et al (1991) A comparison of paroxetine, imipramine and placebo in depressed out-patients. British Journal of Psychiatry, 159, 394398.CrossRefGoogle ScholarPubMed
Edwards, J. G. (1995) Drug choice in depression. Selective serotonin reuptake inhibitors or tricyclic antidepressants? CNS Drugs, 4, 141159.CrossRefGoogle Scholar
Everest, J. T., Tunbridge, R. J. & Widdop, B. (1989). The Incidence of Drugs in Road Accident Fatalities (TRRL Research Report 202). Crowthorne: Transport and Road Research Laboratory.Google Scholar
Frank, E., Kupfer, D. J., Perel, J. M. et al (1990) Three-year outcomes for maintenance therapies in recurrent depression. Archives of General Psychiatry, 47, 10931099.CrossRefGoogle ScholarPubMed
Freeman, H. L. & O'Hanlon, J. E. (1995) Acute and subacute effects of antidepressants on performance. Journal of Drug Development and Clinical Practice, 7, 720.Google Scholar
Georgotas, A., McCue, R. E. & Cooper, T. B. (1989) A placebo-controlled comparison of nortriptyline and phenelzine in maintenance therapy of elderly depressed patients. Archives of General Psychiatry, 46, 783786.Google ScholarPubMed
Henry, J. A. (1997) Toxicity of newer versus older antidepressants. Advances in Psychiatric Treatment, 3, 4044.CrossRefGoogle Scholar
Henry, J. A., Alexander, C. A. & Sener, E. K. (1995) Relative mortality from overdose of antidepressants. British Medical Journal, 310, 221224.CrossRefGoogle ScholarPubMed
Hindmarch, I., Alford, C., Barwell, F. et al (1992) Measuring the side effects of psychotropics: the behavioural toxicity of antidepressants. Journal of Psychopharmacology, 6, 198203.CrossRefGoogle ScholarPubMed
Isacsson, G., Redfors, I., Wasserman, D. et al (1994) Choice of antidepressants: questionnaire survey of psychiatrists and general practitioners in two areas of Sweden. British Medical Journal, 309, 15461549.CrossRefGoogle ScholarPubMed
Jacobi, R. & Lunn, A. D. (1993) How long should the elderly take antidepressants? A double-blind placebo-controlled study of continuation/prophylaxis therapy with dothiepin. British Journal of Psychiatry, 162, 175182.Google Scholar
Jick, S. S., Dean, A. D. & Jick, H. (1995) Antidepressants and suicide. British Medical Journal, 310, 215218.CrossRefGoogle Scholar
Kiloh, L. G., Andrews, G. & Neilson, M. (1988) The long-term outcome of depressive illness. British Journal of Psychiatry, 153, 752757.CrossRefGoogle ScholarPubMed
Kupfer, D. J., Frank, E., Perel, J. M. et al (1992) Five-year outcome for maintenance therapies in recurrent depression. Archives of General Psychiatry, 49, 769773.CrossRefGoogle ScholarPubMed
Lee, A. S. & Murray, R. M. (1988) The long-term outcome of Maudsley depressives. British Journal of Psychiatry, 153, 741751.CrossRefGoogle ScholarPubMed
Lehmann, H. E., Fenton, F. R. & Deutsch, M. et al (1988) An 11-year follow-up study of 110 depressed patients. Acta Psychiatrica Scandinavica, 78, 5765.CrossRefGoogle ScholarPubMed
Leveille, S. G., Buchner, D. M., Koepsell, T. D. et al (1994) Psychoactive medications and injurious motor vehicle collisions involving older drivers. Epidemiology, 5, 591598.CrossRefGoogle ScholarPubMed
Louwerens, J. W., Brookhuis, K. A. & O'Hanlon, J. F. (1986) Several antidepressants' acute effects upon actual driving performance and subjective mental activation. In Drugs and Driving (eds O'Hanlon, J. F. & de Gier, J. J.) pp. 203213. Philadelphia, PA: Taylor and Francis.Google Scholar
Montgomery, S. A. & Dunbar, G. (1993). Paroxetine is better than placebo in relapse prevention and the prophylaxis of recurrent depression. International Clinical Psychopharmacology, 8, 189195.CrossRefGoogle ScholarPubMed
Montgomery, S. A. & Kasper, S. (1995) Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants: A meta-analysis. International Clinical Psychopharmacology, 9 (suppl. 4), 3340.CrossRefGoogle ScholarPubMed
Montgomery, S. A., Dufour, H., Brion, S. et al (1988) The prophylactic efficacy of fluoxetine in unipolar depression. British Journal of Psychiatry, 153 (suppl. 3), 6973.CrossRefGoogle Scholar
Montgomery, S. A., Rasmussen, J. G. C. & Tangh⊘j, P. (1993) A 24-week study of 20 mg citalopram, 40 mg citalopram, and placebo in the prevention of relapse of major depression. International Clinical Psychopharmacology, 8, 181188.CrossRefGoogle ScholarPubMed
Office of Population Censuses and Surveys (1975–1992) Mortality Statistics: Cause. Reviews of the Registrar General on Deaths by Cause, Sex and Age, in England and Wales. London: Her Majesty's Stationery Office.Google Scholar
Parrott, A. C. (1987) Assessment of psychological performance in applied situations. In Human Psychopharmacology. Measures and Methods, vol. 1 (eds Hindmarch, I. & Stonier, P. D.) pp. 93112. Chichester: Wiley.Google Scholar
Parrott, A. C. (1991) Performance tests in human psychopharmacology. 3: Construct validity and test interpretation. Human Psychopharmacology, 6, 197207.CrossRefGoogle Scholar
Ramaekers, J. G., van Veggel, L. M. A. & O'Hanlon, J. F. (1994) A cross-study comparison of the effects of moclobemide and brofaromine on actual driving performance and estimated sleep. Clinical Neuropharmacology, 17 (suppl. 1), S9S18.CrossRefGoogle ScholarPubMed
Ramaekers, J. G., Muntjewerff, N. D. & O'Hanlon, J. F. (1995) A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance. British Journal of Clinical Pharmacology, 39, 397404.CrossRefGoogle ScholarPubMed
Ray, W. A., Fought, R. L. & Decker, M. D. (1992) Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. American Journal of Epidemiology, 136, 873883.CrossRefGoogle ScholarPubMed
Robbe, H. W. J. & O'Hanlon, J. F. (1995) Acute and subchronic effects of paroxetine 20 and 40 mg on actual driving, psychomotor performance and subjective assessments in healthy volunteers. European Neuropsychopharmacology, 5, 3542.CrossRefGoogle ScholarPubMed
Robert, Ph. & Montgomery, S. A. (1995) Citalopram in doses of 20–60 mg is effective in depression relapse prevention: A placebo-controlled 6 month study. International Clinical Psychopharmacology, 10 (suppl. 1), 2935.CrossRefGoogle ScholarPubMed
Robinson, D. S., Lerfald, S. C., Bennet, B. et al (1991) Maintenance therapies in recurrent depression: New findings. Psychopharmacology Bulletin, 27, 3139.Google Scholar
Rouillon, F., Phillips, R., Summer, D. et al (1989) Prophylactic efficacy of maprotiline on relapses of unipolar depression. Encephale, 15, 527534.Google ScholarPubMed
Spina, E. & Perucca, E. (1994) Newer and older antidepressants. A comparative review of drug interactions. CNS Drugs, 2, 479497.CrossRefGoogle Scholar
van Laar, M. W., van Willgenburg, A. P. P. & Volkerts, E. R. (1995) Acute and subchronic effects of nefazodone and imipramine on highway driving, cognitive functions, and daytime sleepiness in healthy adult and elderly subjects. Journal of Clinical Psychopharmacology, 15, 3040.CrossRefGoogle ScholarPubMed
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