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Hyperplasia: The spread of abnormal cells through a plane lattice

Published online by Cambridge University Press:  01 July 2016

Trevor Williams
Affiliation:
University of Bristol
Rolf Bjerknes
Affiliation:
University of Oslo

Extract

When a basal cell divides, both daughter cells remain in the basal layer of the epithelium, with one of the neighbouring cells being pushed out to make room. This fact opens the possibility that a cell with a heritable advantage over the normal cells may gradually produce a clone covering more and more of the basal layer. The advantage in question may consist in a faster rate of division than normal, or a more tenacious hold on the basement membrane; we shall limit consideration to the former situation.

Type
II. Some Particular Epidemic and Cell Models
Copyright
Copyright © Applied Probability Trust 1971 

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