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A study of the neuropsychological correlates in adults with high functioning autism spectrum disorders

Published online by Cambridge University Press:  04 April 2016

Ronna Fried ,
Gagan Joshi ,
Pradeep Bhide ,
Amanda Pope ,
Maribel Galdo ,
Ariana Koster ,
James Chan ,
Stephen V. Faraone  and
Joseph Biederman
Ronna Fried*
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Gagan Joshi
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Pradeep Bhide
Affiliation:
Florida State University College of Medicine, Tallahassee, FL, USA
Amanda Pope
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA
Maribel Galdo
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA
Ariana Koster
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA
James Chan
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA
Stephen V. Faraone
Affiliation:
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA Department of Biomedicine, K.G. Jebsen Centre for Psychiatric Disorders, University of Bergen, Bergen, Norway
Joseph Biederman
Affiliation:
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
*
Ronna Fried, Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, 55 Fruit Street WRN 705, Boston, MA 02114, USA. Tel: +617-724-0963; Fax: +617-724-3742; E-mail: [email protected]
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Abstract

Objective

To examine the unique neuropsychological presentation in adults with high functioning autism spectrum disorders (HF-ASD) by comparison with adults with attention deficit hyperactivity disorder (ADHD).

Methods

Adults with ASD referred to a specialty clinic (n=26) were compared to two non-ASD groups with (n=52) and without (n=52) ADHD of similar age and sex.

Results

No differences in IQ were found. Subjects with HF-ASD were significantly more impaired than both comparison groups in processing speed, cognitive flexibility and sight words. Subjects with HF-ASD were more impaired than controls in working memory, but not the ADHD group.

Conclusion

These findings suggest that there may be specific neuropsychological correlates of HF-ASD differing from ADHD that could have significant implications for identifying individuals at risk for ASD.

Keywords

ADHDautism spectrum disordercognitive flexibilityneuropsychology
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 28 , Issue 5 , October 2016 , pp. 286 - 295
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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References

1. Kogan, MD, Blumberg, SJ, Schieve, LA et al. Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics 2009;124:1395–1403.CrossRefGoogle ScholarPubMed
2. Baird, G, Simonoff, E, Pickles, A et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006;368:210–215.CrossRefGoogle Scholar
3. Fein, D, editor. The neuropsychology of autism. New York: Oxford University Press, 2011.Google Scholar
4. van den Bergh, SF, Scheeren, AM, Begeer, S, Koot, HM, Geurts, HM. Age related differences of executive functioning problems in everyday life of children and adolescents in the autism spectrum. J Autism Dev Disord 2014;44:1959–1971.CrossRefGoogle ScholarPubMed
5. Kenworthy, L, Wallace, GL, Birn, R et al. Aberrant neural mediation of verbal fluency in autism spectrum disorders. Brain Cogn 2013;83:218–226.CrossRefGoogle ScholarPubMed
6. Mayes, SD, Calhoun, SL. WISC-IV and WIAT-II profiles in children with high-functioning autism. J Autism Dev Disord 2008;38:428–439.CrossRefGoogle ScholarPubMed
7. Oliveras-Rentas, RE, Kenworthy, L, Roberson, RB 3rd, Martin, A, Wallace, GL. WISC-IV profile in high-functioning autism spectrum disorders: impaired processing speed is associated with increased autism communication symptoms and decreased adaptive communication abilities. J Autism Dev Disord 2012;42:655–664.CrossRefGoogle ScholarPubMed
8. Nyden, A, Gillberg, C, Hjelmquist, E, Heiman, M. Executive function/attention deficits in boys with Asperger syndrome, attention disorder and reading/writing disorder. Autism 1999;3:213–228.CrossRefGoogle Scholar
9. Ozonoff, S, Jensen, P. Brief report: Specific executive function profiles in three neurodevelopmental disorders. J Autism Dev Disord 1999;29:171–177.CrossRefGoogle ScholarPubMed
10. Geurts, HM, Verte, S, Oosterlaan, J, Roeyers, H, Sergeant, JA. How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J Child Psychol Psychiatry 2004;45:836–854.CrossRefGoogle ScholarPubMed
11. Goldberg, MC, Mostofsky, SH, Cutting, LE et al. Subtle executive impairment in children with autism and children with ADHD. J Autism Dev Disord 2005;35:279–293.CrossRefGoogle ScholarPubMed
12. Happe, F, Booth, R, Charlton, R, Hughes, C. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain Cogn 2006;61:25–39.CrossRefGoogle ScholarPubMed
13. Johnson, CP, Myers, SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007;120:1183–1215.CrossRefGoogle ScholarPubMed
14. Sinzig, J, Morsch, D, Bruning, N, Schmidt, MH, Lehmkuhl, G. Inhibition, flexibility, working memory and planning in autism spectrum disorders with and without comorbid ADHD-symptoms. Child Adolesc Psychiatry Ment Health 2008;2:4.CrossRefGoogle ScholarPubMed
15. Kena, G, Musu-Gillette, L, Robinson, J et al. The condition of education 2015 (NCES 2015-144). Washington, DC: U.S. Department of Education, National Center for Education Statistics, 2015.Google Scholar
16. Shattuck, PT, Narendorf, SC, Cooper, B, Sterzing, PR, Wagner, M, Taylor, JL. Postsecondary education and employment among youth with an autism spectrum disorder. Pediatrics 2012;129:1042–1049.CrossRefGoogle ScholarPubMed
17. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, 4th edn. Washington, DC: American Psychiatric Association, 1994:886 p.Google Scholar
18. Biederman, J, editor. A Once-daily OROS Formulation of Methylphenidate in the treatment of ADHD. American Psychiatric Association 154th Annual Meeting 2001, May 5–10, New Orleans.Google Scholar
19. Orvaschel, H. Schedule for affective disorders and schizophrenia for school-age children epidemiologic version, 5th edn. Ft. Lauderdale: Nova Southeastern University, Center for Psychological Studies, 1994.Google Scholar
20. Biederman, J, Petty, CR, Woodworth, KY, Lomedico, A, Hyder, LL, Faraone, SV. Adult outcome of attention-deficit/hyperactivity disorder: a controlled 16-year follow-up study. J Clin Psychiatry 2012;73:941–950.CrossRefGoogle ScholarPubMed
21. First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. Structured clinical interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press, 1997.Google Scholar
22. Biederman, J, Monuteaux, MC, Mick, E et al. Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med 2006;36:167–179.CrossRefGoogle ScholarPubMed
23. Wechsler, D. Wechsler Abbreviated Scale of Intelligence (WASI), 4th edn. San Antonio, TX: The Psychological Corporation, 1999.Google Scholar
24. Wechsler, D. Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). San Antonio, TX: The Psychological Corporation, 2003.Google Scholar
25. Wechsler, D. Wechsler Adult Intelligence Scale III [manual], 3rd edn. San Antonio, TX: The Psychological Corporation, 1997.Google Scholar
26. Delis, D, Kaplan, E, Kraemer, JH. Delis-Kaplan executive function system (D-KEFS). San Antonio, TX: The Psychological Corporation, 2001.Google Scholar
27. Torgesen, JK, Wagner, RK, Rashotte, CA. Test of Word Reading Efficiency. Austin, TX.: Pro-Ed Inc., 1999.Google Scholar
28. Jastak, J, Jastak, S. Wide Range Achievement Test, 3rd edn. Wilmington, DE: Jastak Associates, 1993.Google Scholar
29. Willcutt, EG, Pennington, BF, Olson, RK, Chhabildas, N, Hulslander, J. Neuropsychological analyses of comorbidity between reading disability and attention deficit hyperactivity disorder: in search of the common deficit. Dev Neuropsychol 2005;27:35–78.CrossRefGoogle ScholarPubMed
30. Shanahan, MA, Pennington, BF, Yerys, BE et al. Processing speed deficits in attention deficit/hyperactivity disorder and reading disability. J Abnorm Child Psychol 2006;34:585–602.CrossRefGoogle ScholarPubMed
31. Corbett, BA, Constantine, LJ, Hendren, R, Rocke, D, Ozonoff, S. Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Res 2009;166:210–222.CrossRefGoogle ScholarPubMed
32. Willcut, E, Sonuga-Barke, EJ, Nigg, JT, Sergeant, JA. Recent developments in neuropsychological models of childhood psychiatric disorders. Adv Biol Psychiatry 2008;24:195–226.CrossRefGoogle Scholar
33. Hervey, AS, Epstein, JN, Curry, JF. Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review. Neuropsychology 2004;18:485–503.CrossRefGoogle ScholarPubMed
34. Seidman, LJ, Doyle, AE, Fried, R, Valera, E, Crum, K, Matthews, L. Neuropsychological function in adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am 2004;27:261–282.CrossRefGoogle ScholarPubMed
35. Dziuk, MA, Gidley Larson, JC, Apostu, A, Mahone, EM, Denckla, MB, Mostofsky, SH. Dyspraxia in autism: association with motor, social, and communicative deficits. Dev Med Child Neurol 2007;49:734–739.CrossRefGoogle ScholarPubMed
36. McCarthy, D, Huizenga, ML, Bell, G et al (editors). Cognitive Flexibility and Frontal Cortical BDNF-TrkB Signaling Following Prenatal Cocaine Exposure. Society for Neuroscience Annual Meeting. Washington, DC: Society for Neuroscience, 2014.Google Scholar