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The Role of Apolipoprotein E in Neuropsychiatric Disorders

Published online by Cambridge University Press:  24 June 2014

S Sundram
S Sundram*
Affiliation:
Mental Health Research Institute, Parkville, Victoria, Australia
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Abstract

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Type
Abstracts from ‘Brainwaves’— The Australasian Society for Psychiatric Research Annual Meeting 2006, 6–8 December, Sydney, Australia
Information
Acta Neuropsychiatrica , Volume 18 , Issue 6 , December 2006 , pp. 333
Copyright
Copyright © 2006 Blackwell Munksgaard

Overview

The most robust genetic predictor of sporadic Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E (apoE) gene. This has spawned much interest into the relevance of this lipid-binding protein in this and other neuropsychiatric disorders and the roles it may play in the central nervous system (CNS). This symposium will present work examining the role of the apoE protein in neuronal function and CNS disorders focusing upon AD, schizophrenia and bipolar disorder. Novel data exploring both central and peripheral functions for apoE and its dysregulation will highlight the relevance of this protein in the pathology of these disorders.