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The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function

Published online by Cambridge University Press:  24 June 2014

Caroline Bell ,
Shamina Bhika ,
Richard Porter ,
Chris Frampton ,
Janet Carter ,
Virginia McIntosh ,
Jenny Jordan  and
Peter Joyce
Caroline Bell*
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Shamina Bhika
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Richard Porter
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Chris Frampton
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Janet Carter
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Virginia McIntosh
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Jenny Jordan
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
Peter Joyce
Affiliation:
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
*
Dr Caroline Bell, Department of Psychological Medicine, University of Otago, PO Box 4345, Christchurch, New Zealand. Tel: +64 3 372 0400; Fax: +64 3 372 0407; E-mail: [email protected]
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Abstract

Background:

Previous studies have suggested that antidepressant treatment of depression may potentiate dopamine transmission through increased sensitivity of postsynaptic D2 receptors.

Method:

D2 receptor function was assessed in 24 patients with major depression before and 16 patients after 16 weeks of treatment with cognitive behavioural therapy (CBT) using a challenge with a selective D2 antagonist, sulpiride. Four hundred milligrams of sulpiride was administered orally on two test days and response was measured by the change in prolactin levels and changes in self-rating scale measures of mood, anxiety and pleasure.

Results:

The prolactin response to sulpiride (as measured by the maximum prolactin level) was significantly increased after CBT (z = −2.792, p = 0.005). Sulpiride resulted in an improvement on mood ratings on both test days, but after CBT, this effect was significantly diminished as measured by the Profile of Mood States score (t = −2.27, p = 0.038).

Conclusions:

After 16 weeks of CBT, we detected an enhanced prolactin response to sulpiride, suggesting an increased sensitivity of D2 receptor functioning.

Keywords

cognitive behavioural therapydepressiondopaminesulpiride
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 4 , August 2008 , pp. 199 - 206
Copyright
Copyright © 2008 Blackwell Munksgaard

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