Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-03T01:05:36.580Z Has data issue: false hasContentIssue false
  • English
  • Français

The relation of sexual dysfunction to depression and anxiety in patients with Parkinson’s disease

Published online by Cambridge University Press:  11 November 2014

Tuba Özcan ,
Erdal Benli ,
Esra Yancar Demir ,
Feriha Özer ,
Yasemin Kaya  and
Canan Erol Haytan
Tuba Özcan*
Affiliation:
Department of Neurology, School of Medicine, Ordu University, Ordu/Turkey
Erdal Benli
Affiliation:
Department of Urology, School of Medicine, Ordu University, Ordu/Turkey
Esra Yancar Demir
Affiliation:
Department of Psychiatry, School of Medicine, Ordu University, Ordu/Turkey
Feriha Özer
Affiliation:
Department of Neurology, School of Medicine, Ordu University, Ordu/Turkey
Yasemin Kaya
Affiliation:
Department of Internal Medicine, School of Medicine, Ordu University, Ordu/Turkey
Canan Erol Haytan
Affiliation:
Department of Neurology, Acipayam State Hospital, Denizli/Turkey
*
Tuba Özcan, Ordu Üniversitesi, Tıp Fakültesi, Nöroloji AD Ordu/Türkiye.Tel: +90 533 479 65 29; Fax: +90 452 234 95 82; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

In this study, we aimed to find out whether sexual dysfunction in patients with Parkinson’s Disease (PD) was associated to PD-related disability and whether this relationship was modulated by depressive and anxiety symptoms.

Methods

Eighty-nine consecutive patients with idiopathic PD who attended to our movement disorders outpatient clinics between January 2011 and June 2014 were included in this study. The diagnosis of PD was confirmed by a movement disorders specialists in Neurology, according to UK Parkinson’s Disease Society Brain Bank Criteria. The Unified PD Rating Scale (UPDRS) motor was used to assess motor disability and Hoehn and Yahr stage (H&Y) was used to establish disease severity. Cognitive function was assessed by the Mini-Mental State Examination. Patients were also administered the Hamilton depression (HAMD) and anxiety (HAMA) rating scales. The sexual functions of the patients were rated by applying the Turkish version of the Arizona Sexual Experiences Scale (ASEX).

Results

The mean age at the time of the study visit was 67.74±9.05. Male/female ratio was 1.87. Mean UPDRS total was 29.06±13.96 and mean UPDRS motor was 17.62±9.07. Mean HAMD score was 13.92±10.86, 58.4% of the patients had minor or major depression; and mean HAMA score was 7.94±6.49, 56.2% of the patients had minor or major anxiety. The mean ASEX score was 18.54±7.27 out of a maximum of 30. ASEX total scores were correlated with age, H&Y stage and HAMA scores. Age and also age at onset were correlated with ASEX subdomains except sexual desire. There was no correlation between disease duration and ASEX subdomains. UPDRS motor score was correlated with erection/lubrication. HAMD was only correlated with orgasm satisfaction. HAMA score was correlated with stimulation and orgasm.

Conclusion

In patients with PD, there may be a common factor that modulates both depression, anxiety and sexual function. Further studies are needed to clarify the exact relationship.

Keywords

anxietydepressionParkinson’s diseasesexual dysfunction
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 1 , February 2015 , pp. 33 - 37
Check for updates
Copyright
© Scandinavian College of Neuropsychopharmacology 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Hughes, AJ, Daniel, SE, Kilford, L, Lees, AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181–184.Google Scholar
2.Witjas, T, Kaphan, E, Azulay, JPet al. Non-motor fluctuations in Parkinson’s disease e frequent and disabling. Neurology 2002;59:408–413.CrossRefGoogle Scholar
3.Meco, G, Rubino, A, Caravona, N, Valente, M. Sexual dysfunction in Parkinson’s disease. Parkinsonism Relat Disord 2008;14:451–456.CrossRefGoogle ScholarPubMed
4.Rees, PM, Fowler, CJ, Maas, CP. Sexual dysfunction 2-sexual function in men and women with neurological disorders. Lancet 2007;369:512–525.Google Scholar
5.Redoute, J, Stoleru, S, Pugeat, Met al. Brain processing of visual sexual stimuli in treated and untreated hypogonadal patients. Psychoneuroendocrinology 2005;30:461–482.Google Scholar
6.Ishihara, L, Brayne, C. A systematic review of depression and mental illness preceding Parkinson’s disease. Acta Neurol Scand 2006;113:211–220.Google Scholar
7.Cummings, JL. Depression and Parkinson’s disease: a review. Am J Psychiatry 1992;149:443–454.Google Scholar
8.Tolosa, E, Gaig, C, Santamaría, J, Compta, Y. Diagnosis and the premotor phase of Parkinson disease. Neurology 2009;72:12–20.Google Scholar
9.Rodríguez-Violante, M, Cervantes-Arriaga, A, Berlanga-Flores, C, Ruiz-Chow, A. Prevalence and determinants of depression in Mexican patients with Parkinson’s disease. Clin Neurol Neurosurg 2012;114:1293–1296.CrossRefGoogle ScholarPubMed
10.Braak, H, Bohl, JR, Muller, CM, Rub, U, De Vos, RA, Del Tredici, K. Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson’s disease reconsidered. Mov Disord 2006;21:2042–2051.Google Scholar
11.Riedel, O, Klotsche, J, Spottke, Aet al. Frequency of dementia, depression, and other neuropsychiatric symptoms in 1449 outpatients with Parkinson’s disease. J Neurol 2010;257:1073–1082.Google Scholar
12.Dissanayaka, NNW, Sellbach, A, Matheson, Set al. Anxiety disorders in Parkinson’s disease: prevalence and risk factors. Mov Disord 2010;25:838–845.CrossRefGoogle ScholarPubMed
13.Davidson, RJ. Anxiety and affective style. Role of prefrontal cortex and amygdala. Biol Psychiatry 2002;51:68–80.Google Scholar
14.Bowron, A, Porter, R, Chandler, B, Walker, R. Sexual dysfunction in PD. Mov Disord 2004;19:28–30.Google Scholar
15.Rosen, RC, Riley, A, Wagner, G, Osterloh, IH, Kirkpatrick, J, Mishra, A. The international index of erectile dysfunction (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822–830.Google Scholar
16.Goetz, CG, Tilley, BC, Shaftman, SRet al. Movement Disorder Society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 2008;2315:2129–2170.Google Scholar
17.Hoehn, M, Yahr, M. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427–442.Google Scholar
18.Folstein, MF, Folstein, SE, Mchugh, PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.Google Scholar
19.Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle ScholarPubMed
20.Hamilton, M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50–55.Google Scholar
21.Mcgahuey, CA, Gelenberg, AJ, Laukes, CA, Moreno, FA, Delgado, PL. The Arizona sexual experience scale (ASEX): reliability and validity. J Sex Marital Ther 2000;26:25–40.Google Scholar
22.Soykan, A. The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res 2004;16:531–534.Google Scholar
23.Basson, R. Sexuality and Parkinson’s disease. Parkinsonism Relat Disord 1996;2:177–185.Google Scholar
24.Bancroft, JH. Sex and aging. N Engl J Med 2007;357:820–822.Google Scholar
25.Moore, O, Gurevich, T, Korczyn, AD, Anca, M, Shabtai, H, Giladi, N. Quality of sexual life in Parkinson’s disease. Parkinsonism Relat Disord 2002;8:243–246.Google Scholar
26.Jacobs, H, Vieregge, A, Vieregge, P. Sexuality in young patients with Parkinson’s disease: a population based comparison with healthy controls. J Neurol Neurosurg Psychiatry 2000;69:550–552.Google Scholar
27.Welsh, M, Hung, L, Waters, CH. Sexuality in women with Parkinson’s disease. Mov Disord 1997;12:923–927.Google Scholar
28.Celikel, E, Ozel-Kizil, ET, Akbostanci, MC, Cevik, A. Assessment of sexual dysfunction in patients with Parkinson’s disease: a case-control study. Eur J Neurol 2008;15:1168–1172.CrossRefGoogle ScholarPubMed
29.Shindel, AW, Eisenberg, ML, Breyer, BN, Sharlip, ID, Smith, JF. Sexual function and depressive symptoms among female North American medical students. J Sex Med 2011;8:391–399.Google Scholar
30.Aslan, E, Beji, NK, Gungor, I, Kadioglu, A, Dikencik, BK. Prevalence and risk factors for low sexual function in women: a study of 1,009 women in an outpatient clinic of a university hospital in Istanbul. J Sex Med 2008;5:2044–2052.Google Scholar
31.Schrag, A, Schott, JM. Epidemiological, clinical, and genetic characteristics of early-onset Parkinsonism. Lancet Neurol 2006;5:355–363.Google Scholar
32.Rojo, A, Aguilar, M, Garolera, MT, Cubo, E, Navas, I, Quintana, S. Depression in Parkinson’s disease: clinical correlates and outcome. Parkinsonism Relat Disord 2003;10:23–28.Google Scholar
33.Wichowicz, HM, Slawek, J, Derejko, M, Cubala, WJ. Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population. Eur Psychiatry 2006;21:516–520.Google Scholar
34.Reijnders, JS, Ehrt, U, Weber, WE, Aarsland, D, Leentjens, AF. A systematic review of prevalence studies of depression in Parkinson’s disease. Mov Disord 2008;23:183–189.CrossRefGoogle ScholarPubMed