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Recognition memory abnormalities in asymptomatic biological parents of a patient with schizophrenia

Published online by Cambridge University Press:  24 June 2014

N. M. J. Edelstyn ,
J. Drakeford ,
F. Oyebode  and
C. D. Findlay
N. M. J. Edelstyn*
Affiliation:
Department of Psychology, University of Keele, Staffordshire
J. Drakeford
Affiliation:
University Department of Psychiatry
F. Oyebode
Affiliation:
University Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham
C. D. Findlay
Affiliation:
Crewe Mental Health Resource Center, Crewe, Cheshire UK
*
Department of Psychology, University of Keele, Keele, Staffordshire ST5 5BG, UK. Tel: (01782) 584318; Fax: 01782 583387; E-mail: [email protected]
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Abstract

Background:

Recognition memory dysfunction has been frequently reported in schizophrenic populations, and has been linked with the development of delusions and thought disorder. A range of neuropsychological abnormalities have also been documented in the biological asymptomatic relatives of patients with schizophrenia; however, recognition memory has not been one of them.

Aim:

This study was carried out in order to investigate: (i) verbal and facial recognition memory in terms of accuracy and false alarm rates; and (ii) contributions from the episodic and semantic memory systems to recognition memory, in the biological asymptomatic parents of a reported schizophrenic patient and a set of male and female psychotic controls.

Results:

Gender differences failed to emerge between the psychotic controls on any of the recognition measures (discrimination accuracy, response bias, hit and false alarm rates, ‘remember’ and ‘know’ recognition memory decisions). However, there was evidence of recognition dysfunction in the female relative, and to a lesser extent, in the male. Both parent's recognition memory performance profiles were marked by a pathologically elevated false alarm rate, and an increased dependence ‘remember’ judgements, i.e. input from the episodic memory system, to drive recognition memory decisions.

Conclusions:

These findings are discussed in the context of models of episodic and semantic memory impairment in schizophrenia.

Keywords

recognition memoryschizophreniaasymptomatic relatives
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 5 , October 2003 , pp. 296 - 303
Copyright
Copyright © 2003 Blackwell Munksgaard

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References

Serby, M, Larson, P, Kalkstein, D. Olfactory sense in psychosis. Biol Psychiatry 1990;28: 829–830.CrossRefGoogle Scholar
Archer, J, Hay, DC, Young, AW. Face processing in psychiatric conditions. Br J Clin Psychol 1992;31: 45–61.CrossRefGoogle ScholarPubMed
Clare, L, McKenna, PJ, Mortimer, AM, Baddeley, AD. Memory in schizophrenia: what is impaired and what is preserved? Neuropsychologia 1993;31: 1225–1241.CrossRefGoogle ScholarPubMed
Pollard, VB, Hellewell, JSE, Deakin, JFW. Performance of schizophrenic subjects on tests of recognition memory, perception and face processing. Schizophr Res 1995;15: 122. CrossRefGoogle Scholar
Brébion, G, Amador, X, David, Aet al. Positive symptomatology and source-monitoring failure in schizophrenia – an analysis of symptom-specific effects. Psychiatr Res 2000;95: 119–131. CrossRefGoogle ScholarPubMed
Mandler, G. Recognizing: the judgment of previous occurrence. Psychol Rev 1980;87: 252–271. CrossRefGoogle Scholar
Jacoby, LL, Dallas, M. On the relationship between autobiographical memory and perceptual learning. J Exp Psychol 1981;110: 306–340. CrossRefGoogle ScholarPubMed
Tulving, E. Memory and consciousness. Can Psychologist 1985;26: 1–12. CrossRefGoogle Scholar
Tulving, E. Episodic memory and common sense. how far apart? Phil Trans Roy Soc London(B) 2001;356: 1505–1515.CrossRefGoogle ScholarPubMed
Bacon, E, Danion, J-M, Kauffmann-Muller, F, Bruant, A. Consciousness in schizophrenia: a metacognitive approach to semantic memory. Consciousness Cogn 2001;10: 473–484. CrossRefGoogle ScholarPubMed
Huron, C, Danion, JM, Giacomoni, Fet al. Impairment of recognition memory with, but not without, conscious recollection in schizophrenia. Am J Psychiatry 1995;152: 1737–1742.Google ScholarPubMed
Danion, J-M, Rizzo, L, Bruant, A. Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Arch General Psychiatry 1999;56: 639–644. CrossRefGoogle ScholarPubMed
Drakeford, JL, Edelstyn, NMJ, Srivastava, S, Oyebode, F. Auditory recognition memory in schizophrenia using the remember/know paradigm. J Neurol Neurosurg Psychiatry 2002;72: 825. Google Scholar
Cannon, TD, Zorrilla, LE, Shtasel, Det al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch General Psychiatry 1994;51: 651–661. CrossRefGoogle ScholarPubMed
Keefe, RSE, Silverman, JM, Lees Roitman, SEet al. Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests. Psychiatr Res 1994;53: 1–12. CrossRefGoogle ScholarPubMed
Bonser, KM, Roxborough, HM, Hellewell, J. Biological relatives of schizophrenic patients show impairments in semantic memory. Schizophr Res 1996;18: 207. CrossRefGoogle Scholar
Kremen, WS, Goldstein, JM, Seidman, LJet al. Sex differences in neuropsycho-logical function in non-psychotic relatives of schizophrenic probands. Psychiatr Res 1997;66: 131–144. CrossRefGoogle Scholar
Kopala, L, Clark, C, Hurwitz, TA. Sex differences in olfactory function in schizophrenia. Am J Psychiatry 1989;146: 1320–1323.Google Scholar
Goldstein, JM, Seidman, LJ, Santangelo, Set al. Are schizophrenic men at risk for developmental deficits than schizophrenic women? Implications for adult neuropsychological functions. J Psychiatr Res 1994;28: 483–498.CrossRefGoogle ScholarPubMed
Edelstyn, NMJ, Drakeford, JL, Oyebode, Fet al. Relationship between Recognition Memory, False Recognition and Delusional Misidentification in Patients with Schizophrenia. Psychopathology 2004In Press. Google Scholar
Benton, ALS, De Hamsher, K, Varney, NR, Spreen, O. Facial Recognition. In: Contributions to Neuropsychological Assessment. Oxford: Oxford University Press, 1983. Google Scholar
Stroop, JR. Stroop Test. Odessa, FL: Psychological Assessment Resources, 1989. Google Scholar
Myers, JE, Myers, KR. Rey Complex Figure Test. Odessa, FL: Psychological Assessment Resources, 1995. Google Scholar
Kopelman, M, Wilson, B, Baddeley, A. The Autobiographical Memory Interview.Bury St. Edmunds Suffolk. Thames Valley Test Co, 1990. Google ScholarPubMed
Wechsler, D. Wechsler Adult Intelligence Scales – Revised. Cleveland, OH: Psychological Corporation, 1981. Google Scholar
Nelson, HE. National Adult Reading Test. Windsor, Berks: NFER-Nelson, 1982. Google Scholar
Snodgrass, JG, Corwin, J. Pragmatics of measuring recognition memory. Applications to dementia and amnesia. J Exp Psychol 1988;117: 34–50. CrossRefGoogle ScholarPubMed
Donaldson, W. Measuring recognition memory. J Exp Psychol 1992;121: 275–277. CrossRefGoogle ScholarPubMed
Edelstyn, NMJ, Riddoch, MJ, Oyebode, Fet al. Visual processing in patients with Frégoli syndrome. Cogn Neuropsychiatry 1996;1: 103–124. CrossRefGoogle ScholarPubMed
Edelstyn, NMJ, Oyebode, F, Booker, E, Humphreys, G. Facial processing and the delusional misidentification syndromes. Cognitive Neuropsychiatry 1998;3: 299–314. Google Scholar
Laws, KR, McKenna, PJ. Psychotic symptoms and cognitive deficits: What relationship? Neurocase 1997;3: 41–49. CrossRefGoogle Scholar