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A rare complication of carcinoÏd carcinoma

Published online by Cambridge University Press:  18 September 2015

W.W. Van Den Broek  and
L. Pepplinkhuizen
W.W. Van Den Broek*
Affiliation:
afd. Psychiatrie van het Academisch Ziekenhuis Rotterdam-Dijkzigt.
L. Pepplinkhuizen
Affiliation:
biologische psychiatrie, Erasmus Universiteit Rotterdam.
*
arts, Afd. Psychiatrie AZR-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam
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Summary

In this case report of a patient with carcinoid carcinoma we discuss the normal metabolism of tryptophan, one of the essential amino acids.

We also examined the changes of this metabolism due to the metastasis of the carcinoid carcinoma and its psychiatric complications based on a central tryptophan deficiency.

A less frequent complication of the changes in the tryptophan metabolism due to carcinoidosis is the disease pellagra. This disease is always accompanied with psychiatric symptoms. It plays an important role in the development of the transmethylation hypothesis of schizophrenia.

Keywords

tryptophancarcinoidpellagrapsychiatrytryptofaancarcinoïdpellagrapsychiatrie
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 2 , Issue 1 , March 1990 , pp. 8 - 12
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1990

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