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The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Published online by Cambridge University Press:  24 June 2014

M Berk  and
G S Malhi
M Berk*
Affiliation:
Department of Psychiatry, University of Melbourne, Geelong, Victoria
G S Malhi
Affiliation:
Mood Disorders Unit at the Black Dog Institute, University of New South Wales, Sydney, Australia
*
Professor Michael Berk, Department of Psychiatry, University of Melbourne, Swanston Center, PO Box 281, Geelong, Victoria, 3220, Australia. Tel. + 61 35226 7410; Fax: + 61 352267436; E-mail: [email protected]
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Abstract

Peripheral markers of psychiatric illness provide a potentially important window into the pathophysiology of a number of psychiatric illnesses. Direct access to pathophysiological processes is fraught with difficulty. However, receptor-regulated second messenger-mediated calcium shifts are an accessible and practical method by which to examine changes in a clinical population. This is possible because platelets and neurons share some physiological features. The platelet intracellular calcium response to receptor stimulation has previously been used as a peripheral marker of psychiatric illness across a range of neurotransmitters, including serotonin, dopamine and glutamate. This review considers the specificity and selectivity of this response and its use in psychotic and mood disorders.

Keywords

intracellular calcium responsemajor depressionperipheral markersplateletpsychiatric illnesspsychosissecond messengers
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 6 , December 2003 , pp. 309 - 315
Copyright
Copyright © 2003 Blackwell Munksgaard

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