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Phenytoin toxicity associated with hypoalbuminaemia and the paradoxical elevation of serum concentration

Published online by Cambridge University Press:  24 June 2014

Masanobu Ito ,
Kotaro Hatta ,
Koichi Miyakawa  and
Heii Arai
Masanobu Ito*
Affiliation:
Department of Psychiatry, Juntendo University Faculty of Medicine, Tokyo, Japan
Kotaro Hatta
Affiliation:
Department of Psychiatry, Juntendo University Faculty of Medicine, Tokyo, Japan
Koichi Miyakawa
Affiliation:
Department of Psychiatry, Juntendo University Faculty of Medicine, Tokyo, Japan
Heii Arai
Affiliation:
Department of Psychiatry, Juntendo University Faculty of Medicine, Tokyo, Japan
*
Masanobu Ito, MD, PhD Department of Psychiatry, Juntendo University Faculty of Medicine, 2-1-1 Bunkyo-ku Hongo, Tokyo 1138421, Japan. Tel/Fax: +81 3 5802 1071; E-mail: masa110@juntendo.ac.jp
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Abstract

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Type
Comment & Critique
Information
Acta Neuropsychiatrica , Volume 23 , Issue 6 , December 2011 , pp. 321 - 322
Copyright
Copyright © Cambridge University Press 2011

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References

1.Bailey, DN, Briggs, JR.The binding of selected therapeutic drugs to human serum alpha-1 acid glycoprotein and to human serum albumin in vitro. Ther Drug Monit 2004;26:40–43.CrossRefGoogle ScholarPubMed
2.Wolf, GK, McClain, CD, Zurakowski, D, Dodson, B, McManus, ML.Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. Pediatr Crit Care Med 2006;7:434–439; quiz 440.CrossRefGoogle Scholar
3.Bajpai, M, Roskos, LK, Shen, DD, Levy, RH.Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite. Drug Metab Dispos 1996;24:1401–1403.Google ScholarPubMed
4.del Carmen Carrasco-Portugal, M, Lujan, M, Flores-Murrieta, FJ.Evaluation of gender in the oral pharmacokinetics of clindamycin in humans. Biopharm Drug Dispos 2008;29:427–430.CrossRefGoogle ScholarPubMed
5.Hayakawa, H, Fujimaki, K, Shimizu, Y, Tai, M, Himaizumi, H.Metabolic fate of pazufloxacin mesilate in humans and animals. Nippin Kagakuryouhou Gakkai Zasshi 1999;47:81–87.Google Scholar
6.Lindow, J, Wijdicks, EF.Phenytoin toxicity associated with hypoalbuminemia in critically ill patients. Chest 1994;105:602–604.CrossRefGoogle ScholarPubMed
7.Chua, HC, Venketasubramanian, N, Tjia, H, Chan, SP.Elimination of phenytoin in toxic overdose. Clin Neurol Neurosurg 2000;102:6–8.CrossRefGoogle ScholarPubMed
8.Correia, MA. Drug biotransformation. In: Katzung, BG, ed. Basic & clinical pharmacology, 11th edn. New York: McGraw Hill, 2009:66.Google Scholar
9.Ijiri, Y, Nakai, H, Suzuki, K, Ohi, K, Fukuoka, E, Fukuya, T.A case report, suggested clockwise hysteresis loop during phenytoin intoxication. Jpn J TDM 1999;16:127–128.Google Scholar