Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-22T23:11:20.059Z Has data issue: false hasContentIssue false
  • English
  • Français

Parkinson's disease and depression

Published online by Cambridge University Press:  18 September 2015

A.F.G. Leentjens  and
W.W. Van Den Broek
W.W. Van Den Broek
Affiliation:
afd. Psychiatrie, AZR Dijkzigt
Get access Rights & Permissions [Opens in a new window]

Summary

In this review article, based on a literature study, present ideas upon the relation between M. Parkinson and concomittant depression are dicussed. After a short introduction, it is demonstrated that epidemiological studies show that a common pathophysiological basis can be assumed. Briefly pheno-menological aspects are mentioned, whereafter the changes in the different neurotransmittersystems are discussed in greater detail. The ratio of dopaminergic and serotonergic activities in the basal ganglia constitute an important determinant for the severity of motor symptoms in Parkinson's disease. Reduced serotonergic metabolism may be a compensatory mechanism for the reduced dopaminergic activity. At the same time, a reduced serotonergic activity can predispose to a depression. Lower activities in parts of the dopaminergic, serotonergic and noradrenergic systems may each be responsible for part of the affective symptomatology in depressed Parkinson patients.

Keywords

M. ParkinsondepressiondopamineserotonineM. Parkinsondepressiedopamineserotonine
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 5 , Issue 4 , December 1993 , pp. 83 - 87
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1Parkinson, J. An essay on the shaking palsy. London: Sherwood, Neely & Jones, 1817.Google Scholar
2Ball, B. De l'insanite dans la paralysie agitante. Encephale 1882;2:22–52.Google Scholar
3Gowers, WR. A manual of diseases of the nervous system. London: Churchill, 1886.Google Scholar
4Mindham, RHS. Psychiatric aspects of Parkinson's disease. Br J Hosp Med 1974;11:411-14.Google Scholar
5Celesia, GG, Wanamaker, WM. Psychiatric disturbances in Parkinson's disease. Dis nerv Syst 1972;33:577-83.Google ScholarPubMed
6Mayeux, R, Stern, Y, Rosen, J, Leventhal, J. Depression, intellectual impairment and Parkinson's disease. Neurology 1981;31:645-50.CrossRefGoogle Scholar
7Cummings, JL. Depression and Parkinson's disease: A Review. Am J Psychiat 1992;149:443-54.Google ScholarPubMed
8Frijns, CJM, Koerselman, GF. Depressie bij de ziekte van Parkinson. Tijdsch Psychiat 1992;33:313-27.Google Scholar
9Dooneief, G, Mirabello, E, Bell, K, Marder, K, Stern, Y, Mayeux, R. An estimate of the incidence of depression in idiopathic Parkinson's disease. Arch Neurol 1992;49:305-7.CrossRefGoogle ScholarPubMed
10Starkstein, SE, Preziosi, TJ, Bolduc, PL, Robinson, RG. Depression in Parkinson's disease. J nerv ment Dis 1990;178:27–31.CrossRefGoogle ScholarPubMed
11Mayeux, R, Stern, Y, Williams, JBW, Cote, L, Frantz, A, Dyrenfurth, I. Clinical and biochemical features of depression in Parkinson's disease. Am J Psychiat 1986;143:756-9.Google ScholarPubMed
12Robins, AH. Depression in patients with parkinsonism. Br J Psychiat 1976;128:141-5.CrossRefGoogle ScholarPubMed
13Horn, S. Some psychological factors in parkinsonism. J Neurol Neurosurg Psychiat 1974;37:27–31.CrossRefGoogle ScholarPubMed
14Kearney, TR. Parkinson's disease, presenting as a depressive illness. J Ir med Ass 1964;54:117-9.Google ScholarPubMed
15Marsh, CG, Markham, CH. Does levodopa alter depression and psychopathology in parkinsonism patients? J Neurol Neurosurg Psychiat 1973;36:925-35.CrossRefGoogle ScholarPubMed
16Gotham, AM, Brown, RG, Marsden, CD. Depression in Parkinson's disease: a quantitative and qualitative analysis. J Neurol Neurosurg Psychiat 1986;49:381-89.CrossRefGoogle ScholarPubMed
17Brown, RG, Maccarthy, B, Gotham, AM, Der, GJ, Marsden, CD. Depression and disability in Parkinson's disease: a follow-up of 132 cases. Psychol Med 1988;18:49–55.CrossRefGoogle ScholarPubMed
18Huber, SJ, Freidenberg, DL, Paulson, GW, Shuttleworth, EC, Christy, JA. The pattern of depressive symptoms varies with progression of Parkinson's disease. J Neurol Neurosurg Psychiat 1990;53:275-8.CrossRefGoogle ScholarPubMed
19Emanuels-Zuurveen, ES, Brouwer, WH, Lakke, JPWF, Bouhuys, AL. Lichamelijke symptomen van de ziekte van Parkinson en de score op de Beck's Depression Inventory. Tijdschr Geront Geriat 1991;22:134-7.Google Scholar
20Hovestadt, A. Parkinson's disease: cognition, pulmonary function and muscle strength (proefschrift). Delft: Eburon Publisher, 1990:36–46.Google Scholar
21Kostic, VS, Susie, V, Przedborski, S, Sternic, N. Sleep EEG in depressed and nondepressed patients with Parkinson's disease. J Neuropsychiat clin Neurosci 1991;3:176-9.Google ScholarPubMed
22Hornykiewicz, O. Dopamine (3-hydroxytyramine) and brain function. Pharmacol Rev 1966;18:925-64.Google ScholarPubMed
23Javoy-Agid, F, Agid, Y. Is the mesocortical dopaminergic system involved in Parkinson disease? Neurology 1980;30:1326-30.CrossRefGoogle ScholarPubMed
24Torack, RM, Morris, JC. The association of ventral tegmental area histopathology with adult dementia. Arch Neurol 1988;45:497–501.CrossRefGoogle ScholarPubMed
25Mayberg, HS, Starkstein, SE, Sadzot, B, et al.Selective hypometa-bolism in the inferior frontal lobe in depressed patients with Parkinson's disease. Ann Neurol 1990;28:57–64.CrossRefGoogle ScholarPubMed
26Sandyk, R, Iacono, RP. The hypothalamus in Parkinson disease. Int J neurol Sci 1987;8:227-34.Google ScholarPubMed
27van Praag, HM. Neurotransmitters and CNS disease: Depression. Lancet 1982;1:1259-64.CrossRefGoogle Scholar
28van Praag, HM, Asnis, GM, Kahn, RS, et al.Monoamines and abnormal behaviour: a multi-aminergic perspective. Br J Psychiat 1990;157:723-34.CrossRefGoogle ScholarPubMed
29Nissenbaum, H, Quinn, NP, Brown, RG, Toone, B, Gotham, AM, Marsden, CD. Mood swings associated with the “on-off” phenomenon in Parkinson's Disease. Psychol Med 1987;17:899–904.CrossRefGoogle ScholarPubMed
30Goetz, CG, Tanner, CM, Klawans, HL. Bupropion in Parkinson's disease. Neurol 1984;34:1092-4.CrossRefGoogle ScholarPubMed
31Birkmayer, W, Birkmayer, JD. Dopamine action and disorders of neurotransmitter balance. Geront 1987;33:168-71.CrossRefGoogle ScholarPubMed
32Lloyd, KG. Neurochemistry of the substantia nigra in Parkinson's disease. Abstracts int Soc Neurochem 1977;252.Google Scholar
33Mayeux, R, Stern, Y, Cote, L, Williams, JBW. Altered serotonin metabolism in depressed patients with Parkinson's disease. Neurology 1984;34:642-46.CrossRefGoogle ScholarPubMed
34Perry, EK, Curtis, M, Dick, DJ, et al.Cholinergic correlates of cognitive impairment in Parkinson's disease: a comparison with Alzheimer's disease. J Neurol 1985;48:413-21.Google ScholarPubMed
35Sandyk, R, Fisher, H. L-tryptophan supplementation in Parkinson's disease. Int J Neurosc 1989;45:215-19.CrossRefGoogle ScholarPubMed
36Lebensohn, ZM, Jenkins, RB. Improvement of parkinsonism in depressed patients treated with ECT. Am J Psychiat 1975;123:283-85.Google Scholar
37Riederer, P, Birkmayer, W. A new concept: brain area specific imbalence of neurotransmitters in depression Syndrome-human brain studies. In: Usdin, E, Sourkes, TL, Youdim, MBH, red. Enzymes and Neurotransmitters in mental Disease. New York: John Wiley & Sons, 1980:261-79.Google Scholar
38Orzeck, A, Barbeau, A. Interrelationships among dopamine, seroto-nine and acetylcholine. In: Barbeau, A, McDowell, FH, red. L-DOPA and Parkinsonism. Philadelphia: FA Davis Co 1970;88–94.Google Scholar