Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-22T06:21:24.940Z Has data issue: false hasContentIssue false
  • English
  • Français

No allelic association between harm avoidance and the debrisoquine 4-hydroxylase gene

Published online by Cambridge University Press:  24 June 2014

Adriaan H Veefkind ,
Theo J M Ingenhoven  and
Izaäk W De Groot
Adriaan H Veefkind
Affiliation:
Psychiatric Center Symfora Groep, Amersfoort, the Netherlands
Theo J M Ingenhoven
Affiliation:
Psychiatric Center Symfora Groep, Amersfoort, the Netherlands
Izaäk W De Groot*
Affiliation:
Psychiatric Center Symfora Groep, Amersfoort, the Netherlands
*
Dr I.W. de Groot, Psychologist, Symfora Groep, locatie Zon & Schild, Afdeling Wetenschappelijk Onderzoek, Medisch Centrum, PO Box 3051, 3800 DB Amersfoort, the Netherlands. Tel: +33 4609568; Fax: +33 4609576; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Several reports suggest that variance in personality traits is inherited, but little is known about the genes responsible. It has been suggested that there is a relationship between personality characteristics and the gene responsible for the activity of the enzyme debrisoquine 4-hydroxylase (CYP2D6).

Objective:

To examine the proportion of poor metabolizers in a group of personality disordered patients.

Methods:

Blood samples were obtained from 23 patients with a high or very high score on the dimension ‘harm avoidance’ of the Temperament and Character Inventory (TCI). The samples were genotyped for the null alleles CYP2D6*3 and*4 by performing an allele-specific polymerase chain reaction.

Results:

The frequencies of genotypes in the sample were very similar to the frequencies found in a general white population.

Conclusions:

The investigation produced no support for the idea that the CYP2D6 gene is related to personality by means of variations in the temperament dimension of harm avoidance.

Keywords

cytochrome P450 2D6harm avoidancepersonalityTCI
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 14 , Issue 5 , October 2002 , pp. 216 - 218
Copyright
Copyright © Acta Neuropsychiatrica 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Llerena, A, Edman, G, Cobaleda, J, Benitez, J, Schalling, D, Bertilsson, L.Relationship between personality and debrisoquine hydroxylation capacity. Acta Psychiatr Scand 1993;87: 23–28.CrossRefGoogle ScholarPubMed
Cloninger, CR, Svrakic Przybeck, TR.A psychobiological model of temperament and character. Arch General Psychiatry 1993;50: 975–990. CrossRefGoogle ScholarPubMed
Herbst, JH, Zonderman, AB, McCrea, RR, Costa, PT Jr.Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. Am J Psychiatry 2000;157: 1285–1290.CrossRefGoogle ScholarPubMed
Bertilsson, L, Alm, C, De Las Carreras, C, Widén, J, Edman, G, Schalling, D.Debrisoquine hydroxylation polymorphism and personality. The Lancet 1989;ii: 555. CrossRefGoogle Scholar
Sachse, C, Brockmöller, J, Bauer, S, Roots, I.Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1987;60: 284–295. Google Scholar
Niznik, HB, Tyndale, RF, Sallee, FR, Gonzalez, FJ, Hardwick, JP, Inaba, Tet al. The dopamine transporter and cytochrome P450IIDVI (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct binding proteins. Arch Biochem Biophys 1990;276: 424–432.CrossRefGoogle Scholar
Cloninger, CR, Przybeck, TR.The Temperament and Character Inventory (TCI). A Guide to its Development and Use. St Louis: Center for Psychobiology of Personality, 1994. Google Scholar
Duijsens, IJ, Spinhoven, PH. TCI Handleiding van de Nederlandse Temperament en Karakter Vragenlijst. Leiderdorp, The Netherlands: Datec, 2000. Google Scholar
Veefkind, Ah, Haffmans, PJM, Hoenkamp, E.Venlafaxine serum levels and CYP2D6 genotype. Ther Drug Monitoring 2000;22: 202–208. CrossRefGoogle ScholarPubMed